Granular cell ameloblastoma in maxilla: A report of rare case

Ameloblastoma is the most common odontogenic tumor found at the posterior region of mandible. Granular cell ameloblastoma is one of the histological subtypes of ameloblastoma, mainly characterized by nests of large eosinophilic granular cell. Here, we reported a rare case of 75-year-old female patient presented with granular cell ameloblastoma in maxilla region. The conventional surgery was performed by upper lip-splitting technique and partial maxillectomy. The prosthetic obturators were delivered to rehabilitate a maxillofacial integrity, improving facial appearance and functional abilities. Long-term follow up revealed a favorable outcome without an evidence of tumor recurrence

Evaluation of CD44s, CD44v6, CXCR2, CXCL1, and IL-1β in Benign and Malignant Tumors of Salivary Glands

Background: Several studies have reported an association between high expression of CD44 in different types of cancer. However, no study has reported a link among CD44 expression, other biomarkers, and the aggressiveness of salivary gland tumors. Methods: A total of 38 specimens were obtained from non-tumorous salivary glands, benign and malignant tumors in salivary glands. Immunohistochemical analyses of CD44s, CD44v6, IL-1β, CXCL1, and CXCR2 were performed, and the area of positive cells was assessed. Results: We found that both CD44s and CXCR2 expression were increased in the benign and malignant groups. CD44v6 was also increased in both groups, but it had the highest level in the malignant group. IL-1β was the only biomarker that increased significantly in the malignant group in comparison to the other two groups. Conclusions: CD44s, CD44v6, CXCR2, and IL-1β expressions were found to be higher in salivary gland tumors. However, IL-1β alone may play a crucial role in the aggressiveness of salivary gland tumors as this cytokine was expressed only in the malignant group with high expression associated with high-grade malignancy