Neuro-endovascular service in The University of Hong Kong Shenzhen Hospital

Conference Theme: Brain Attack: A New EraOral Poster Presentation I: paper no. FP1-03BACKGROUND: The University Hong Kong Shenzhen Hospital (HKU-SZH) is a newly established hospital and its neuroscience unit is affiliated with Queen Mary Hospital in Hong Kong. Its establishment in 2012 was part of a pilot scheme in healthcare reform in Mainland China. Acute stroke is an emerging healthcare burden in the aging population in China. In the management of acute stroke, endovascular intervention plays an important role; in particular for ...postprin

Efficacy of a Novel Injection Lipolysis to Induce Targeted Adipocyte Apoptosis: A Randomized, Phase IIa Study of CBL-514 Injection on Abdominal Subcutaneous Fat Reduction

Background: CBL-514 is a novel injectable drug that may be safe and efficacious for localized abdominal subcutaneous fat reduction. Objectives: The aim of this study was to assess the safety and efficacy of CBL-514 in reducing abdominal subcutaneous fat volume and thickness. Methods: This Phase IIa, open-label, random allocation study consisted of a 6-week treatment period and follow-up at 4 and 8 weeks following the last treatment. Participants were randomly allocated to receive 1.2 mg/cm2 (180 mg), 1.6 mg/cm2 (240 mg), or 2.0 mg/cm2 (300 mg) of CBL-514 with up to 4 treatments, each comprising 60 injections into the abdominal adipose layer. Changes in abdominal subcutaneous fat were assessed by ultrasound at follow-up visits. Treatment-emergent adverse events were recorded. Results: Higher doses of CBL-514 (unit dose, 2.0 and 1.6 mg/cm2) significantly improved the absolute and percentage reduction in abdominal fat volume (P < 0.00001) and thickness (P < 0.0001) compared with baseline. Although the COVID-19 pandemic halted some participant recruitment and follow-ups, analysis was unaffected, even after sample size limitations. Conclusions: CBL-514 injection at multiple doses up to 300 mg with a unit dose of 2.0 mg/cm2 is safe, well-tolerated, and reduced abdominal fat volume and thickness by inducing adipocyte apoptosis. Although other procedures exist to treat abdominal fat, they have limitations and may cause complications. At a dose of 2.0 mg/cm2, CBL-514 safely and significantly reduced abdominal fat volume by 24.96%, making it a promising new treatment for routine, nonsurgical abdominal fat reduction in dermatologic clinics. Level of Evidence: 4

Dorsal root entry zone approach in spinal intramedullary tumours: a revisit and review of the technique

Meeting Theme: Degenerative Lumbar SpineOral-Poster Presentation IINTRODUCTION: Surgical excision is the mainstay treatment for the intramedullary spinal cord tumour. However, when no tumour exposed on the surface of the spinal cord in this kind of tumour, myelotomy is required. Median myelotomy (MM) is the standard approach to be described in the literatures, but we did encounter complications probably related to this approach solely. After such incidents, we adopted the dorsal root entry zone myelotomy (DREZM) approach in the surgery treating these intramedullary tumours …published_or_final_versio

Symptomatic hyperperfusion after surgical revascularization for moyamoya disease: incidence, natural history and preictors

Conference Theme: Brain Attack: A New EraFree Paper 8AIM: To study the incidence, natural history and predictors for post-revascularization symptomatic hyperperfusion in moyamoya patient ...postprin

Surgical management of intracranial meningioma: two-year experience of 27 patients

Conference Theme: Brain Attack: A New EraOral Poster Presentation 2: paper no. FP2-01INTRODUCTION: Meningioma is one of the most common intracranial tumors. Although it responds favorably to surgical resection, its surgical management is impacted by several factors ...postprin

Associations of apolipoprotein E exon 4 and lipoprotein lipase S447X polymorphisms with acute ischemic stroke and myocardial infarction

Background: Because apolipoprotein E (apoE) and lipopoprotein lipase (LPL) polymorphisms interact with each other and with other factors to affect lipid metabolism, we sought to determine their separate and combined effects in association with ischemic vascular disease. Methods: We performed a case-control study of 816 subjects: 246 acute ischemic stroke patients, 234 acute myocardial infarction patients, and 336 controls. APOE exon 4 and LPL S447X genotypes were determined. Results: APOE ε2 and ε4 homozygotes were increased in stroke (4.5% vs. 1.0%, p = 0.008), while in myocardial infarction the ε4 allele was increased (12.6% vs. 9.5%, p = 0.006) but ε2 was decreased (3.7% vs. 12.1%, p = 0.000006). For subjects with either APOE ε2 or ε4 alleles, LPL X alleles were increased in vascular disease (OR = 2.2, p = 0.01). LPL X alleles displayed opposite tendencies toward association with disease when subjects were divided by sex, smoking, or APOE genotype. Meta-analysis and regression analysis of previous studies supported the sex and smoking dichotomies. Conclusion: This is the first report of an association of vascular disease with an interaction of APOE exon 4 and LPL S447X genotypes. Therefore, APOE genotypes and LPL S447X interactions with apoE, sex, and smoking may affect the risk of myocardial infarction and ischemic stroke. © 2006 by Walter de Gruyter.published_or_final_versio

Moyamoya disease: 14-year experience in a single institution in Hong Kong

Conference Theme: Degenerative Lumbar SpineOral-Poster Presentation 1OBJECTIVE: To review the presentation and treatment outcome after intervention for patients with Moyamoya disease in the past 14 years. METHODS: All 43 hospitalized patients with Moyamoya disease admitted from 2001 to 2014 in our centre were included in this retrospective study. Disease presentation, initial radiological findings, operative details, clinical and imaging follow-up data were reviewed …published_or_final_versio

Prevention and treatment of oral mucositis caused by chemo- and radiotherapy in head and neck cancer patient

ICOMS 2017 Abstracts Only SupplementBackground: Oral mucositis is one of the most common complications of chemo- and radiotherapy for treatment of cancer. This condition is prevalent in up to 40% of individuals who are undergoing cancer therapy. Adverse reactions include but not limited to malnutrition, prolonged hospital stays, increased risk of infection and negative impact in quality of life. Objectives: The purpose of this study was to examine and compare current evidence on treatment modalities for oral mucositis by performing a systemic review. A literature search identified for randomised controlled trials (RCTs) for preventive and therapeutic intervention of oral mucositis in head and neck cancer patients undergoing radiation therapy and/or chemotherapy. Methods: This systematic review followed the Cochrane Collaboration Handbook of Interventions Systematic Reviews and the PRISMA statement checklist and flowchart. A sensitive search protocol was developed to retrieve RCTs published in peer-reviewed journals from 1980 to September 2016 using MEDLINE via PubMed (1970–September 2016), EMBASE via Ovid (1980–September 2016). Search queries included MeSH terms for: oral mucositis; chemotherapy; radiotherapy; head and neck cancer. Identification of randomised trials was done according to CONSORT statement. 11 articles on laser therapy; 10 articles on topical treatment and 8 articles on medical therapy were included into the final review. Findings and Conclusion: The outcome of this study has identified effective medical and surgical interventions for prevention and treatment of oral mucositis. Further trials will be necessary to identify a superior modality or protocol as a standard therapy of radio- and chemotherapy-induced oral mucositis. Copyright © 2017 Published by Elsevier Ltd