1,747 research outputs found

    Genes encoding hub and bottleneck enzymes of the Arabidopsis metabolic network preferentially retain homeologs through whole genome duplication

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    <p>Abstract</p> <p>Background</p> <p>Whole genome duplication (WGD) occurs widely in angiosperm evolution. It raises the intriguing question of how interacting networks of genes cope with this dramatic evolutionary event.</p> <p>Results</p> <p>In study of the <it>Arabidopsis </it>metabolic network, we assigned each enzyme (node) with topological centralities (in-degree, out-degree and between-ness) to measure quantitatively their centralities in the network. The <it>Arabidopsis </it>metabolic network is highly modular and separated into 11 interconnected modules, which correspond well to the functional metabolic pathways. The enzymes with higher in-out degree and between-ness (defined as hub and bottleneck enzymes, respectively) tend to be more conserved and preferentially retain homeologs after WGD. Moreover, the simultaneous retention of homeologs encoding enzymes which catalyze consecutive steps in a pathway is highly favored and easily achieved, and enzyme-enzyme interactions contribute to the retention of one-third of WGD enzymes.</p> <p>Conclusions</p> <p>Our analyses indicate that the hub and bottleneck enzymes of metabolic network obtain great benefits from WGD, and this event grants clear evolutionary advantages in adaptation to different environments.</p

    Localized Histoplasma capsulatum osteomyelitis of the fibula in an immunocompetent teenage boy: a case report

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    BACKGROUND: Infection of local bone with Histoplasma capsulatum is rare and difficult to diagnosis, and occurs particularly in immunocompetent subjects, who are more likely to be affected by a wide range of organisms. CASE PRESENTATION: An 11-year-old boy presented with localized histoplasmosis osteomyelitis in the left fibula without any evidence of abnormal immunological function or systemic disease. After surgical clearance of the lesion and homologous cancellous bone, the patient was treated orally with voriconazole for 6 months. The patient completely recovered with full function of his left leg during the 5-year follow-up. CONCLUSIONS: Histoplasmosis osteomyelitis can occasionally occur in immunocompetent individuals and can be complete cured by surgical clearance of the lesion and antibiotic treatment

    EventCLIP: Adapting CLIP for Event-based Object Recognition

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    Recent advances in zero-shot and few-shot classification heavily rely on the success of pre-trained vision-language models (VLMs) such as CLIP. Due to a shortage of large-scale datasets, training such models for event camera data remains infeasible. Thus, adapting existing models across modalities is an important research challenge. In this work, we introduce EventCLIP, a novel approach that utilizes CLIP for zero-shot and few-shot event-based object recognition. We first generalize CLIP's image encoder to event data by converting raw events to 2D grid-based representations. To further enhance performance, we propose a feature adapter to aggregate temporal information over event frames and refine text embeddings to better align with the visual inputs. We evaluate EventCLIP on N-Caltech, N-Cars, and N-ImageNet datasets, achieving state-of-the-art few-shot performance. When fine-tuned on the entire dataset, our method outperforms all existing event classifiers. Moreover, we explore practical applications of EventCLIP including robust event classification and label-free event recognition, where our approach surpasses previous baselines designed specifically for these tasks.Comment: Better few-shot accuracy. Add results on 1) model fine-tuning 2) compare with concurrent works 3) learning from unlabeled data (unsupervised & semi-supervised

    Review of Anomaly Detection Based on Log Analysis

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    Coupled Cooling Method and Application of Latent Heat Thermal Energy Storage Combined with Pre-cooling of Envelope: Sensitivity Analysis and Optimization

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    This document is the Accepted Manuscript version of the following article: Xiangkui gao, Yanping Yuan, Hongwei Wu, and Xudong Zhao, ‘Coupled Cooling Method and Application of Latent Het Thermal Energy Storage Combined with Pre-cooling of Envelope: Sensitivity Analysis and Optimization’, Process Safety and Environmental Protection, first published online 9 March 2017. Under embargo. Embargo end date: 9 March 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ The version of record is available online at doi: http://dx.doi.org/10.1016/j.psep.2017.03.005 © 2017 Elsevier Ltd. All rights reserved.Cooling system for mine refuge chamber provides comfortable environment for miners to avoid heat damage. The existing cooling systems have their own application scopes and limitations. The coupled cooling method of Latent Heat Thermal Energy Storage (LHTES) combined with Pre-cooling of Envelope (PE) is a new free cooling method which is suitable for high-temperature, passive, impact and other harsh environment. Then, to improve the thermal comfort and reduce energy consumption, the effect of the pre-cooling temperature, melting temperature of PCM, aspect ratio and amounts of PCM unit on the indoor temperature are investigated in a systematic manner. Furthermore, the system is optimized and the generalized results for the evaluation parameter are given. Analysis of the results may lead to following main conclusions: (i) the method really controls the indoor temperature and the saving amount of PCM is more than 50% compared to the traditional LHTES systems; (ii) the Temperature Control(TC) performance of PCM would drop significantly if it melts more than 80%; (iii) under current operating conditions, the optimal melting temperature is about 29 °C and the aspect ratio of PCM unit is 60:500; (iv) per 1 °C the pre-cooling temperature dropped, 19% the actual amount of PCM decreased for the case studied.Peer reviewedFinal Accepted Versio
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