Climate change adaptation among female-led micro, small, and medium enterprises in semiarid areas: a case study from Kenya

This chapter contributes to the literature on private sector adaptation by empirically exploring how female-led micro, small, and medium enterprise (MSMEs) in Kenya’s semiarid lands (SALs) experience and respond to climate risk. The chapter argues that strong sociocultural orientations around gender roles and resource use and access not only confine female-led MSMEs to sectors that experience higher exposure to climate risk – most notably agriculture – but also trigger more pronounced barriers to building resilience within their businesses, including reduced access to land, capital, markets, new technology, and educational opportunities. Faced by these barriers, female entrepreneurs may pursue unsustainable forms of coping, as part of which business activity is scaled back through reduced profits, loss of business, and the sale of valuable business assets. Such strategies may help enterprises to cope in the short term but may undermine longer-term MSME adaptive capacity. Social networks, such as women’s groups and table banking initiatives, appear to be crucial adaptation tools. Additionally, a strong dependency exists between household resilience and business resilience, implying that building resilience at the household level could support adaptive capacity among female-led MSMEs. Supporting the adaptive capacity of women in business should be a policy priority

Rapid Changes in the Light/Dark Cycle Disrupt Memory of Conditioned Fear in Mice

Background: Circadian rhythms govern many aspects of physiology and behavior including cognitive processes. Components of neural circuits involved in learning and memory, e.g., the amygdala and the hippocampus, exhibit circadian rhythms in gene expression and signaling pathways. The functional significance of these rhythms is still not understood. In the present study, we sought to determine the impact of transiently disrupting the circadian system by shifting the light/ dark (LD) cycle. Such ‘‘jet lag’ ’ treatments alter daily rhythms of gene expression that underlie circadian oscillations as well as disrupt the synchrony between the multiple oscillators found within the body. Methodology/Principal Findings: We subjected adult male C57Bl/6 mice to a contextual fear conditioning protocol either before or after acute phase shifts of the LD cycle. As part of this study, we examined the impact of phase advances and phase delays, and the effects of different magnitudes of phase shifts. Under all conditions tested, we found that recall of fear conditioned behavior was specifically affected by the jet lag. We found that phase shifts potentiated the stress-evoked corticosterone response without altering baseline levels of this hormone. The jet lag treatment did not result in overall sleep deprivation, but altered the temporal distribution of sleep. Finally, we found that prior experience of jet lag helps to compensate for the reduced recall due to acute phase shifts. Conclusions/Significance: Acute changes to the LD cycle affect the recall of fear-conditioned behavior. This suggests that

Rab11-FIP1C and Rab14 Direct Plasma Membrane Sorting and Particle Incorporation of the HIV-1 Envelope Glycoprotein Complex

The incorporation of the envelope glycoprotein complex (Env) onto the developing particle is a crucial step in the HIV-1 lifecycle. The long cytoplasmic tail (CT) of Env is required for the incorporation of Env onto HIV particles in T cells and macrophages. Here we identify the Rab11a-FIP1C/RCP protein as an essential cofactor for HIV-1 Env incorporation onto particles in relevant human cells. Depletion of FIP1C reduced Env incorporation in a cytoplasmic tail-dependent manner, and was rescued by replenishment of FIP1C. FIP1C was redistributed out of the endosomal recycling complex to the plasma membrane by wild type Env protein but not by CT-truncated Env. Rab14 was required for HIV-1 Env incorporation, and FIP1C mutants incapable of binding Rab14 failed to rescue Env incorporation. Expression of FIP1C and Rab14 led to an enhancement of Env incorporation, indicating that these trafficking factors are normally limiting for CT-dependent Env incorporation onto particles. These findings support a model for HIV-1 Env incorporation in which specific targeting to the particle assembly microdomain on the plasma membrane is mediated by FIP1C and Rab14. © 2013 Qi et al.Link_to_subscribed_fulltex

Measuring and Building Community Disaster Resilience: Essential for Achieving Sendai

Disaster risk and resulting impacts are on the rise, threatening development gains. The Sendai Framework for Disaster Risk Reduction seeks to tackle the underlying drivers of risk, namely increasing exposure, and promote well-being. Achieving the goals of Sendai requires a shift in practice, away from the status quo in DRM and toward a holistic and system-thinking approach to disaster resilience that is centered on development. This chapter outlines one such approach, that of the Zurich Flood Resilience Alliance, to measure and build community flood resilience in 118 communities across nine countries. The links between the Flood Resilience Measurement for Communities (FRMC) measurement tool and linked resilience-building interventions and the goals of the Sendai Framework are outlined to demonstrate the potential of resilience for tackling the underlying drivers of increasing disaster risk