18 research outputs found
Salivary cortisol levels and dental anxiety in children with attention deficit hyperactivity disorder
Vaginal birth after classical Caesarean section
Current belief in obstetric practice is that the scar of a classical Caesarean section is more prone to rupture than that of a lower segment Caesarean section and that for this reason elective repeat Caesarean should always be undertaken in subsequent pregnancies
Critical Nitrogen Deposition Loads in High-elevation Lakes of the Western US Inferred from Paleolimnological Records
Access to glacial and subglacial environments in the Solar System by melting probe technology
Regional analysis of inorganic nitrogen yield and retention in high-elevation ecosystems of the Sierra Nevada and Rocky Mountains
Reporting of sex and gender in randomized controlled trials in Canada: a cross-sectional methods study
Background:
Accurate reporting on sex and gender in health research is integral to ensuring that health interventions are safe and effective. In Canada and internationally, governments, research organizations, journal editors, and health agencies have called for more inclusive research, provision of sex-disaggregated data, and the integration of sex and gender analysis throughout the research process. Sex and gender analysis is generally defined as an approach for considering how and why different subpopulations (e.g., of diverse genders, ages, and social locations) may experience health conditions and interventions in different or similar ways.
The objective of this study was to assess the extent and nature of reporting about sex and/or gender, including whether sex and gender analysis (SGA) was carried out in a sample of Canadian randomized controlled trials (RCTs) with human participants.
Methods:
We searched MEDLINE from 01 January 2013 to 23 July 2014 using a validated filter for identification of RCTs, combined with terms related to Canada. Two reviewers screened the search results to identify the first 100 RCTs that were either identified in the trial publication as funded by a Canadian organization or which had a first or last author based in Canada. Data were independently extracted by two people from 10% of the RCTs during an initial training period; once agreement was reached on this sample, the remainder of the data extraction was completed by one person and verified by a second.
Results:
The search yielded 1433 records. We screened 256 records to identify 100 RCTs which met our eligibility criteria. The median sample size of the RCTs was 107 participants (range 12–6085). While 98% of studies described the demographic composition of their participants by sex, only 6% conducted a subgroup analysis across sex and 4% reported sex-disaggregated data. No article defined “sex” and/or “gender.” No publication carried out a comprehensive sex and gender analysis.
Conclusions:
Findings highlight poor uptake of sex and gender considerations in the Canadian RCT context and underscore the need for better articulated guidance on sex and gender analysis to improve reporting of evidence, inform policy development, and guide future research.Applied Science, Faculty ofMedicine, Faculty ofNon UBCAnesthesiology, Pharmacology and Therapeutics, Department ofNursing, School ofReviewedFacult