14 research outputs found

    The notion of inscripturation

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    Even if the following reasoning is a priori determined by my faith-conviction concerning its outcome, i.e. even if I cannot escape from my "hermeneutical circle", I may still reason in the following way (cf. Ott, 1972:45; Berkhof, 1985:81f; Potgieter, 1990:18)

    The credibility of scripture

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    This paper is about the recent North-American evangelical discussion between errantists and inerrantists, i.e. around the "inerrancy" of Scripture

    Differential and stage-related expression in embryonic tissues of a new human homoeobox gene

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    The homoeobox is a 183 base-pair (bp) DNA sequence conserved in several Drosophila genes controlling segmentation and segment identity. Homoeobox sequences have been detected in the genome of species ranging from insects and anellids to vertebrates and homoeobox containing genes have been cloned from Xenopus, mouse and man. We recently isolated human homoeobox containing complementary DNA clones, that represent transcripts from four different human genes. One clone (HHO.c10) is selectively expressed in a 2.1 kilobase (kb) polyadenylated transcript in the spinal cord of human embryos and fetuses 5-10 weeks after fertilization. We report the characterization of a second cDNA clone, termed HHO.c13, that represents a new homoeobox gene. This clone encodes a protein of 255 amino-acid residues, which includes a pentapeptide, upstream of the homoeo domain, conserved in other Drosophila, Xenopus, murine and human homoeobox genes. By Northern analysis HHO.c13 detects multiple embryonic transcripts, which are differentially expressed in spinal cord, brain, backbone rudiments, limb buds and heart in 5-9-week-old human embryos and fetuses, in a striking organ- and stage-specific pattern. These observations suggest that in early mammalian development homoeobox genes may exert a wide spectrum of control functions in a variety of organs and body parts, in addition to the spinal cord
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