24 research outputs found
The entropic penalty of ordered water accounts for weaker binding of the antibiotic novobiocin to a resistant mutant of DNA gyrase: a thermodynamic and crystallography study
Kinetic and structural characteristics of the inhibition of enoyl (acyl carrier protein) reductase by triclosan
Analysis of isothermal titration calorimetry data for complex interactions using I2CITC
I2CITC allows the analysis of isothermal titration calorimetry (ITC) data for complex coupled equilibria. Here we describe how, using I2CITC, ITC data for systems involving a self-aggregating ligand and a host offering one or two binding sites can be analyzed, how interaction models can be tested, and how confidence intervals for the optimized parameters can be determined