31 research outputs found
An off-board quantum point contact as a sensitive detector of cantilever motion
Recent advances in the fabrication of microelectromechanical systems (MEMS)
and their evolution into nanoelectromechanical systems (NEMS) have allowed
researchers to measure extremely small forces, masses, and displacements. In
particular, researchers have developed position transducers with resolution
approaching the uncertainty limit set by quantum mechanics. The achievement of
such resolution has implications not only for the detection of quantum behavior
in mechanical systems, but also for a variety of other precision experiments
including the bounding of deviations from Newtonian gravity at short distances
and the measurement of single spins. Here we demonstrate the use of a quantum
point contact (QPC) as a sensitive displacement detector capable of sensing the
low-temperature thermal motion of a nearby micromechanical cantilever.
Advantages of this approach include versatility due to its off-board design,
compatibility with nanoscale oscillators, and, with further development, the
potential to achieve quantum limited displacement detection.Comment: 5 pages, 5 figure
Intensity Modulated Radiotherapy (IMRT) and Fractionated Stereotactic Radiotherapy (FSRT) for children with head-and-neck-rhabdomyosarcoma
<p>Abstract</p> <p>Background</p> <p>The present study evaluates the outcome of 19 children with rhabdomyosarcoma of the head-and-neck region treated with Intensity Modulated Radiotherapy (IMRT) or Fractionated Stereotactic Radiotherapy (FSRT) between August 1995 and November 2005.</p> <p>Methods</p> <p>We treated 19 children with head-and-neck rhabdomyosarcoma with FSRT (n = 14) or IMRT (n = 5) as a part of multimodal therapy. Median age at the time of radiation therapy was 5 years (range 2–15 years). All children received systemic chemotherapy according to the German Soft Tissue Sarcoma Study protocols.</p> <p>Median size of treatment volume for RT was 93,4 ml. We applied a median total dose of 45 Gy (range 32 Gy – 54 Gy) using a median fractionation of 5 × 1,8 Gy/week (range 1,6 Gy – 1,8 Gy).</p> <p>The median time interval between primary diagnosis and radiation therapy was 5 months (range 3–9 months).</p> <p>Results</p> <p>After RT, the 3- and 5-year survival rate was 94%. The 3- and 5-year actuarial local control rate after RT was 89%.</p> <p>The actuarial freedom of distant metastases rate at 3- and 5-years was 89% for all patients.</p> <p>Radiotherapy was well tolerated in all children and could be completed without interruptions > 4 days. No toxicities >CTC grade 2 were observed. The median follow-up time after RT was 17 months.</p> <p>Conclusion</p> <p>IMRT and FSRT lead to excellent outcome in children with head-and-neck RMS with a low incidence of treatment-related side effects.</p