Not All Countries Celebrate Thanksgiving: On the Cultural Dominance in Large Language Models

In this paper, we identify a cultural dominance issue within large language models (LLMs) due to the predominant use of English data in model training (e.g. ChatGPT). LLMs often provide inappropriate English-culture-related answers that are not relevant to the expected culture when users ask in non-English languages. To systematically evaluate the cultural dominance issue, we build a benchmark that consists of both concrete (e.g. holidays and songs) and abstract (e.g. values and opinions) cultural objects. Empirical results show that the representative GPT models suffer from the culture dominance problem, where GPT-4 is the most affected while text-davinci-003 suffers the least from this problem. Our study emphasizes the need for critical examination of cultural dominance and ethical consideration in their development and deployment. We show two straightforward methods in model development (i.e. pretraining on more diverse data) and deployment (e.g. culture-aware prompting) can significantly mitigate the cultural dominance issue in LLMs

Quantitative Assessment of Regional Debris-Flow Risk: A Case Study in Southwest China

This paper uses a comprehensive risk assessment method to investigate the population risk of debris flows in Southwest China. The methodology integrates models from hazard, vulnerability literature and some empirical equations. The main steps include debris-flow disaster-hazard zoning, estimation of the frequency of the disaster, factor identification of population vulnerability, and calculation of the fragility rate. The results demonstrate that the most hazardous regions in Southwest China are primarily observed in the mountains around the Sichuan Basin, the border area between Sichuan and Yunnan Provinces, the eastern and southern regions of Yunnan Province, and the eastern area of Guizhou Province. The extremely high vulnerability zones are characterized by a fragility rate of 3.89 persons per 10,000 people. The comprehensive risk gradually increases from the southeast of the study area to the central region, reaching its highest value (more than 100 persons/year) on the Jiangyou–Zhaotong–Baoshan Line and decreasing thereafter to its lowest in the northwestern region. Extremely large-scale disasters are the major factor of casualties. Appropriate risk management and mitigation solutions should be comprehensively determined based on the combination of debris-hazard levels and fragility rates in the hazardous regions

Mesenchymal stem cells and porous β-tricalcium phosphate composites prepared through stem cell screen-enrich-combine(−biomaterials) circulating system for the repair of critical size bone defects in goat tibia

Abstract Background Efficacious bone substitute is essential for the treatment of a critical size bone defect. Currently, the bone substitutes commonly used in clinical practice lack osteogenic capacity and the therapeutic efficacy is not ideal. Herein, a novel stem cell screen-enrich-combine(−biomaterials) circulating system (SECCS) was introduced to provide the substitutes with osteogenic ability. The stem cell screening, enrichment, and recombination with substitutes could be integrated during the surgical operation. Using SECCS, the bioactive mesenchymal stem cells (MSCs) and porous β-tricalcium phosphate (β-TCP) composites (MSCs/β-TCP) were rapidly prepared for critical size bone defect repair and validated in goat models of critical size tibia defects. Methods Twelve goats with right hind limb tibia defects of 30 mm were randomly divided into two groups: six (the experimental group) were treated with MSCs/β-TCP prepared by SECCS and the other six goats (the control group) were treated with pure porous β-TCP. The repair effect was assessed by x-ray, computed tomography (CT), micro-CT, histology and histomorphology 6 months after the operation. In addition, the enrichment efficacy of MSCs and the characteristics of the MSCs/β-TCP prepared by SECCS were evaluated. Results The SECCS could compound about 81.3 ± 3.0% of the MSCs in bone marrow to the porous β-TCP without affecting the cell viability. The average number of MSCs for retransplantation was 27,655.0 ± 5011.6 for each goat from the experimental group. In vitro, satisfactory biocompatibility of the MSCs/β-TCP was performed, with the MSCs spreading adequately, proliferating actively, and retaining the osteogenic potential. In vivo, the defect repair by MSCs/β-TCP with good medullary cavity recanalization and cortical remodeling was significantly superior to that of pure porous β-TCP. Conclusions The MSCs/β-TCP prepared through SECCS demonstrated significant therapeutic efficacy in goat models of critical size bone defect. This provides a novel therapeutic strategy for critical size bone defects caused by severe injury, infection, and bone tumor resection with a high profile of safety, effectiveness, simplicity, and ease

A GIS METHOD FOR ASSESSING ROOF-MOUNTED SOLAR ENERGY POTENTIAL: A CASE STUDY IN JIANGSU, CHINA

Ministry of Science and Technology of the People's Republic of China 2008BAK50B06The abundant and inexhaustible solar energy has been widely considered a viable solution to the energy-shortage problem as well as the pollution of the environment. Therefore, it is an urgent need to perform detailed and reliable estimation of available solar resource in order to shift from traditional fossil fuels to the rich solar energy. However, such a scientific action has been often taken simply from the theoretical reserves, with few regards for the specific using scenarios. This paper initially presented a GIS based scenario method for assessing available roof-mounted solar energy resource. The data input are from land use map, meteorological data and aerial data, which are all easily reached; and the performance could give the potential of using roof-mounted PV system. Then Jiangsu province, one of the well-developed provinces in China, was chosen as a case study to calibrate it. The results gave estimation that annual electrical production capacity in the province could meet about 40% of the local demand. The huge potential is compared with the theoretical amount directly for the solar radiation. Analysis showed that this method was more reliable according to the actual situation of using solar energy, and could be directly promoted in managing traditional energy risk and making energy development plans

A Conantokin Peptide Con-T[M8Q] Inhibits Morphine Dependence with High Potency and Low Side Effects

N-methyl-D-aspartate receptor (NMDAR) antagonists have been found to be effective to inhibit morphine dependence. However, the discovery of the selective antagonist for NMDAR GluN2B with low side-effects still remains challenging. In the present study, we report a selective NMDAR GluN2B antagonist con-T[M8Q](a conantokin-T variant) that potently inhibits the naloxone-induced jumping and conditioned place preference of morphine-dependent mice at nmol/kg level, 100-fold higher than ifenprodil, a classical NMDAR NR2B antagonist. Con-T[M8Q] displays no significant impacts on coordinated locomotion function, spontaneous locomotor activity, and spatial memory mice motor function at the dose used. Further molecular mechanism experiments demonstrate that con-T[M8Q] effectively inhibited the transcription and expression levels of signaling molecules related to NMDAR NR2B subunit in hippocampus, including NR2B, p-NR2B, CaMKII-α, CaMKII-β, CaMKIV, pERK, and c-fos. The high efficacy and low side effects of con-T[M8Q] make it a good lead compound for the treatment of opiate dependence and for the reduction of morphine usage

Surgical masks as source of bacterial contamination during operative procedures

Background: Surgical masks (SMs) are used to reduce bacterial shedding from the mouth, nose and face. This study aimed to investigate whether SMs may be a potential source of bacterial shedding leading to an increased risk of surgical site infection. Methods: Bacterial contamination of the SMs was tested by making an impression of the external surface of the mask on sterile culture media immediately. We investigated the difference in bacterial counts between the SMs worn by surgeons and those placed unused in the operating room (OR), and the bacterial count variation with indicated wearing time. Moreover, the difference in bacterial counts on the external surface between the first and second layers of double-layered SMs was also assessed. Results: The bacterial count on the surface of SMs increased with extended operating times; significant difference was found between the 4- to 6-hour and 0-hour groups (p < 0.05). When we analysed the bacterial counts from the same surgeon, a significant increase was noted in the 2-hours group. Moreover, the bacterial counts were significantly higher among the surgeons than the OR. Additionally, the bacterial count of the external surface of the second mask was significantly higher than that of the first one. Conclusions: The source of bacterial contamination in SMs was the body surface of the surgeons rather than the OR environment. Moreover, we recommend that surgeons should change the mask after each operation, especially those beyond 2 hours. Double-layered SMs or those with excellent filtration function may also be a better alternative. The translational potential of this article: This study provides strong evidence for the identification that SMs as source of bacterial contamination during operative procedures, which should be a cause for alarm and attention in the prevention of surgical site infection in clinical practice. Keywords: Hospital-acquired infection, Surgical mask, Surgical site infectio