16 research outputs found
Interrogating Proton Affinities of Organophosphonate Species Via Atmospheric Flow Tube Mass Spectrometry and Computational Methods
Liberation movements, universal citizenship and the resolution of ethno-national conflict: anc
Compromised mutant EFEMP1 secretion associated with macular dystrophy remedied by proteostasis network alteration
R345W EFEMP1 is secreted poorly, causing the macular dystrophy malattia leventinese. A novel assay shows that other substitutions (F, Y, P) at residue 345 impair secretion, partly by reducing native disulfide bonds. EFEMP1 secretion is rescued by reduced growth temperature and translational attenuation—potential strategies to delay disease