3 research outputs found
Critical ischemia time in a model of spinal cord section. A study performed on dogs
Vascular changes after acute spinal cord trauma are important factors that predispose quadriplegia, in most cases irreversible. Repair of the spinal blood flow helps the spinal cord recovery. The average time to arrive and perform surgery is 3Â h in most cases. It is important to determine the critical ischemia time in order to offer better functional prognosis. A spinal cord section and vascular clamping of the spinal anterior artery at C5âC6 model was used to determine critical ischemia time. The objective was to establish a critical ischemia time in a model of acute spinal cord section. Four groups of dogs were used, anterior approach and vascular clamp of spinal anterior artery with 1, 2, 3, and 4Â h of ischemia and posterior hemisection of spinal cord at C5âC6 was performed. Clinical evaluation was made during 12Â weeks and morphological evaluation at the end of this period. We obtained a maximal neurological coordination at 23Â days average. Two cases showed sequels of right upper limb paresis at 1 and 3 ischemia hours. There was nerve conduction delay of 56% at 3Â h of ischemia. Morphological examination showed 25% of damaged area. The VIII and IX Rexedâs laminae were the most affected. The critical ischemia time was 3Â h. Dogs with 4Â h did not exhibit any recovery