8 research outputs found

    The role of Notch in tumorigenesis: oncogene or tumour suppressor?

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    Notch signalling participates in the development of multicellular organisms by maintaining the self-renewal potential of some tissues and inducing the differentiation of others. Involvement of Notch in cancer was first highlighted in human T-cell leukaemia, fuelling the notion that aberrant Notch signalling promotes tumorigenesis. However, there is mounting evidence that Notch signalling is not exclusively oncogenic. It can instead function as a tumour suppressor

    Placebo effects and their determinants in gastrointestinal disorders

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