1,628 research outputs found
Mass inflation in f(R) gravity: A conjecture on the resolution of the mass inflation singularity
We study gravitational collapse of a charged black hole in f(R) gravity using
double-null formalism. We require cosmological stability to f(R) models; we
used the Starobinsky model and the R + (1/2)cR^2 model. Charged black holes in
f(R) gravity can have a new type of singularity due to higher curvature
corrections, the so-called f(R)-induced singularity, although it is highly
model-dependent. As the advanced time increases, the internal structure will
approach the Cauchy horizon, which may not be an inner apparent horizon. There
is mass inflation as one approaches the Cauchy horizon and hence the Cauchy
horizon may be a curvature singularity with nonzero area. However, the Ricci
scalar is finite for an out-going null observer. This can be integrated as
follows: Cosmologically stable higher curvature corrections of the Ricci scalar
made it bounded even in the presence of mass inflation. Finally, we conjecture
that if there is a general action including general higher curvature
corrections with cosmological stability, then the corrections can make all
curvature components finite even in the presence of mass inflation. This might
help us to resolve the problem of inner horizon instability of regular black
hole models.Comment: 31 pages, 15 figure
The Significance of Calcium-sensing Receptor in Sustaining Photosynthesis and Ameliorating Stress Responses in Plants
Calcium ions (Ca2+) regulate plant growth and development during exposure to multiple biotic and abiotic stresses as the second signaling messenger in cells. The extracellular calcium-sensing receptor (CAS) is a specific protein spatially located on the thylakoid membrane. It regulates the intracellular Ca2+Β responses by sensing changes in extracellular Ca2+Β concentration, thereby affecting a series of downstream signal transduction processes and making plants more resilient to respond to stresses. Here, we summarized the discovery process, structure, and location of CAS in plants and the effects of Ca2+Β and CAS on stomatal functionality, photosynthesis, and various environmental adaptations. Under changing environmental conditions and global climate, our study enhances the mechanistic understanding of calcium-sensing receptors in sustaining photosynthesis and mediating abiotic stress responses in plants. A better understanding of the fundamental mechanisms of Ca2+Β and CAS in regulating stress responses in plants may provide novel mitigation strategies for improving crop yield in a world facing more extreme climate-changed linked weather events with multiple stresses during cultivation
Managing Linguistic Data Summaries in Advanced P2P Applications
chapitre... Γ corrigerAs the amount of stored data increases, data localization techniques become no longer sufficient in P2P systems. A practical approach is to rely on compact database summaries rather than raw database records, whose access is costly in large P2P systems. In this chapter, we describe a solution for managing linguistic data summaries in advanced P2P applications which are dealing with semantically rich data. The produced summaries are synthetic, multidimensional views over relational tables. The novelty of this proposal relies on the double summary exploitation in distributed P2P systems. First, as semantic indexes, they support locating relevant nodes based on their data descriptions. Second, due to their intelligibility, these summaries can be directly queried and thus approximately answer a query without the need for exploring original data. The proposed solution consists first in defining a summary model for hierarchical P2P systems. Second, appropriate algorithms for summary creation and maintenance are presented. A query processing mechanism, which relies on summary querying, is then proposed to demonstrate the benefits that might be obtained from summary exploitation
Surgical excision promotes tumor growth and metastasis by promoting expression of MMP-9 and VEGF in a breast cancer model
Surgery is still the main curative therapeutic modality for breast cancer. Although surgery often results in the successful removal of the primary tumor, its process could increase the risk of metastases of residual cancer cells. Understanding of the connection between breast cancer metastasis and surgical wound will lead to the establishment of a proper treatment strategy for postoperative cancer patient. Aim: To study the influence of surgical procedure on the metastasis of primary breast cancer. Methods: We established MDA-MB-435 human breast cancer xenograft model. Levels of Pro-matrix metalloproteinase 9 (Pro-MMP-9) and vascular endothelial growth factor (VEGF) in host serum and tumors were tested at different time points with ELISA and zymography and correlated to tumor growth and postoperative metastasis. Results: Our study demonstrated surgical wound had promoting effect on tumor growth and pulmonary metastasis of human breast cells, if tumor cells remain in bodies. This effect might be related to the postoperative interaction of cancer and host cells, which resulted in expression of Pro-MMP-9. Surgical process could also increase the VEGF expression in tumor tissues. Conclusions: Surgical wound-produced host Pro-MMP-9 and tumor cell VEGF might be important mediators leading to metastasis of residual breast cancer after surgery.Π₯ΠΈΡΡΡΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ΅ Π»Π΅ΡΠ΅Π½ΠΈΠ΅ Π΄ΠΎ ΡΠΈΡ
ΠΏΠΎΡ ΠΎΡΡΠ°Π΅ΡΡΡ Π³Π»Π°Π²Π½ΡΠΌ ΡΠ΅ΡΠ°ΠΏΠ΅Π²ΡΠΈΡΠ΅ΡΠΊΠΈΠΌ ΠΏΠΎΠ΄Ρ
ΠΎΠ΄ΠΎΠΌ ΠΏΡΠΈ Π»Π΅ΡΠ΅Π½ΠΈΠΈ Π±ΠΎΠ»ΡΠ½ΡΡ
ΡΠ°ΠΊΠΎΠΌ ΠΌΠΎΠ»ΠΎΡΠ½ΠΎΠΉ
ΠΆΠ΅Π»Π΅Π·Ρ. Π₯ΠΎΡΡ Ρ
ΠΈΡΡΡΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΡΠ΄Π°Π»Π΅Π½ΠΈΠ΅ ΠΎΠΏΡΡ
ΠΎΠ»ΠΈ Π² Π±ΠΎΠ»ΡΡΠΈΠ½ΡΡΠ²Π΅ ΡΠ»ΡΡΠ°Π΅Π² Π΄ΠΎΡΡΠ°ΡΠΎΡΠ½ΠΎ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎ, Π² ΡΠΎ ΠΆΠ΅ Π²ΡΠ΅ΠΌΡ ΠΎΠ½ΠΎ ΠΌΠΎΠΆΠ΅Ρ
ΡΠ²Π΅Π»ΠΈΡΠΈΡΡ ΡΠΈΡΠΊ ΠΌΠ΅ΡΠ°ΡΡΠ°Π·ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΎΡΡΠ°ΡΠΎΡΠ½ΡΡ
ΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΡΡ
ΠΊΠ»Π΅ΡΠΎΠΊ. ΠΠΎΠ½ΠΈΠΌΠ°Π½ΠΈΠ΅ ΡΠ²ΡΠ·ΠΈ ΠΌΠ΅ΠΆΠ΄Ρ ΠΌΠ΅ΡΠ°ΡΡΠ°Π·ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΠΏΡΠΈ ΡΠ°ΠΊΠ΅
ΠΌΠΎΠ»ΠΎΡΠ½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ ΠΈ ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠΉ ΡΠ°Π½ΠΎΠΉ ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΡ Π²ΡΠ±ΡΠ°ΡΡ Π½Π°ΠΈΠ»ΡΡΡΡΡ ΡΡΡΠ°ΡΠ΅Π³ΠΈΡ ΠΏΠΎΡΡΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ Π»Π΅ΡΠ΅Π½ΠΈΡ. Π¦Π΅Π»Ρ:
ΠΎΠΏΡΠ΅Π΄Π΅Π»ΠΈΡΡ Π²Π»ΠΈΡΠ½ΠΈΠ΅ Ρ
ΠΈΡΡΡΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π²ΠΌΠ΅ΡΠ°ΡΠ΅Π»ΡΡΡΠ²Π° Π½Π° ΠΌΠ΅ΡΠ°ΡΡΠ°Π·ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΎΠΏΡΡ
ΠΎΠ»ΠΈ. ΠΠ΅ΡΠΎΠ΄Ρ: Π±ΡΠ»Π° ΡΠΎΠ·Π΄Π°Π½Π° ΠΌΠΎΠ΄Π΅Π»Ρ ΡΠ°ΠΊΠ°
ΠΌΠΎΠ»ΠΎΡΠ½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° Π² Π²ΠΈΠ΄Π΅ ΠΊΡΠ΅Π½ΠΎΡΡΠ°Π½ΡΠΏΠ»Π°Π½ΡΠ°ΡΠ° MDA-MB-435. Π£ΡΠΎΠ²Π΅Π½Ρ Pro-ΠΌΠ°ΡΡΠΈΡΠ½ΠΎΠΉ ΠΌΠ΅ΡΠ°Π»Π»ΠΎΠΏΡΠΎΡΠ΅ΠΈΠ½Π°Π·Ρ 9
(Pro-MMP-9) ΠΈ ΡΠ°ΠΊΡΠΎΡΠ° ΡΠΎΡΡΠ° ΡΠ½Π΄ΠΎΡΠ΅Π»ΠΈΡ ΡΠΎΡΡΠ΄ΠΎΠ² (VEGF) Π² ΡΡΠ²ΠΎΡΠΎΡΠΊΠ΅ ΡΠ΅ΡΠΈΠΏΠΈΠ΅Π½ΡΠ° ΠΈ ΠΎΠΏΡΡ
ΠΎΠ»ΡΡ
ΠΎΡΠ΅Π½ΠΈΠ²Π°Π»ΠΈΡΡ Π² ΡΠ°Π·Π½ΡΠ΅
Π²ΡΠ΅ΠΌΠ΅Π½Π½ΡΠ΅ ΠΏΡΠΎΠΌΠ΅ΠΆΡΡΠΊΠΈ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ELISA ΠΈ Π·ΠΈΠΌΠΎΠ³ΡΠ°ΡΠΈΠΈ. ΠΡΠΈ ΡΡΠΎΠΌ ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΠ»ΠΈ Π½Π°Π»ΠΈΡΠΈΠ΅ ΠΊΠΎΡΠ΅Π»Π»ΡΡΠΈΠΈ ΠΌΠ΅ΠΆΠ΄Ρ ΡΡΠΈΠΌΠΈ ΠΏΠΎΠΊΠ°Π·Π°- ΠΈ Π·ΠΈΠΌΠΎΠ³ΡΠ°ΡΠΈΠΈ. ΠΡΠΈ ΡΡΠΎΠΌ ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΠ»ΠΈ Π½Π°Π»ΠΈΡΠΈΠ΅ ΠΊΠΎΡΠ΅Π»Π»ΡΡΠΈΠΈ ΠΌΠ΅ΠΆΠ΄Ρ ΡΡΠΈΠΌΠΈ ΠΏΠΎΠΊΠ°Π·Π° ΠΈ Π·ΠΈΠΌΠΎΠ³ΡΠ°ΡΠΈΠΈ. ΠΡΠΈ ΡΡΠΎΠΌ ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΠ»ΠΈ Π½Π°Π»ΠΈΡΠΈΠ΅ ΠΊΠΎΡΠ΅Π»Π»ΡΡΠΈΠΈ ΠΌΠ΅ΠΆΠ΄Ρ ΡΡΠΈΠΌΠΈ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΡΠΌΠΈ,
ΡΠΎΡΡΠΎΠΌ ΠΎΠΏΡΡ
ΠΎΠ»ΠΈ ΠΈ ΠΏΠΎΡΡΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΡΠΌΠΈ ΠΌΠ΅ΡΠ°ΡΡΠ°Π·Π°ΠΌΠΈ. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ: Π±ΡΠ»ΠΎ ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½Π°Ρ ΡΠ°Π½Π° ΡΠΏΠΎΡΠΎΠ±ΡΡΠ²ΡΠ΅Ρ
ΡΠΎΡΡΡ ΠΎΠΏΡΡ
ΠΎΠ»ΠΈ ΠΌΠΎΠ»ΠΎΡΠ½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ ΠΈ Π΅Π΅ ΠΌΠ΅ΡΠ°ΡΡΠ°Π·ΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π² Π»Π΅Π³ΠΊΠΈΠ΅ Π² ΡΠ»ΡΡΠ°Π΅, ΠΊΠΎΠ³Π΄Π° ΠΏΡΠΈ ΡΠ΄Π°Π»Π΅Π½ΠΈΠΈ ΠΎΠΏΡΡ
ΠΎΠ»ΠΈ Π² ΡΠ°Π½Π΅
ΠΎΡΡΠ°ΡΡΡΡ ΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΡΠ΅ ΠΊΠ»Π΅ΡΠΊΠΈ. ΠΡΠΎ ΠΌΠΎΠΆΠ΅Ρ Π±ΡΡΡ ΡΠ²ΡΠ·Π°Π½ΠΎ Ρ ΠΏΠΎΡΡΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΡΠΌ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ΠΌ ΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΡΡ
ΠΈ ΠΎΠΊΡΡΠΆΠ°ΡΡΠΈΡ
ΠΈΡ
Π½ΠΎΡΠΌΠ°Π»ΡΠ½ΡΡ
ΠΊΠ»Π΅ΡΠΎΠΊ, ΠΊΠΎΡΠΎΡΠΎΠ΅ ΠΏΡΠΈΠ²ΠΎΠ΄ΠΈΡ ΠΊ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ Pro-MMP-9. Π£Π΄Π°Π»Π΅Π½ΠΈΠ΅ ΠΎΠΏΡΡ
ΠΎΠ»ΠΈ ΠΌΠΎΠΆΠ΅Ρ ΡΠ°ΠΊΠΆΠ΅ ΡΠΏΠΎΡΠΎΠ±ΡΡΠ²ΠΎΠ²Π°ΡΡ
ΡΠ²Π΅Π»ΠΈΡΠ΅Π½ΠΈΡ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ VEGF ΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΡΠΌΠΈ ΠΊΠ»Π΅ΡΠΊΠ°ΠΌΠΈ. ΠΡΠ²ΠΎΠ΄Ρ: Pro-MMP-9, ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΡΡΠ΅ΠΌΡΠΉ Π½ΠΎΡΠΌΠ°Π»ΡΠ½ΡΠΌΠΈ ΠΊΠ»Π΅ΡΠΊΠ°ΠΌΠΈ,
ΠΎΠΊΡΡΠΆΠ°ΡΡΠΈΠΌΠΈ ΠΏΠΎΡΡΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΡΡ ΡΠ°Π½Ρ, Π° ΡΠ°ΠΊΠΆΠ΅ VEGF, ΠΏΡΠΎΠ΄ΡΡΠΈΡΡΠ΅ΠΌΡΠΉ ΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΡΠΌΠΈ ΠΊΠ»Π΅ΡΠΊΠ°ΠΌΠΈ, ΠΌΠΎΠ³ΡΡ Π±ΡΡΡ Π²Π°ΠΆΠ½ΡΠΌΠΈ
ΠΌΠ΅Π΄ΠΈΠ°ΡΠΎΡΠ°ΠΌΠΈ ΠΌΠ΅ΡΠ°ΡΡΠ°Π·ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΎΡΡΠ°ΡΠΎΡΠ½ΡΡ
ΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΡΡ
ΠΊΠ»Π΅ΡΠΎΠΊ ΠΏΠΎΡΠ»Π΅ Ρ
ΠΈΡΡΡΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π²ΠΌΠ΅ΡΠ°ΡΠ΅Π»ΡΡΡΠ²Π°
Manipulation of magnetization reversal of Ni81Fe19 nanoellipse arrays by tuning the shape anisotropy and the magnetostatic interactions
Two series of highly ordered two-dimensional arrays of Ni81Fe19 nanoellipses were nanofabaricated with different aspect ratios, R, and element separations, S, to investigate the influence of the self-demagnetization and the magnetostatic interaction upon the magnetization reversal. For nanostructures with low shape anisotropy, an additional magnetic easy axis was induced orthogonal to the shape-induced easy axis by reducing the separations along both axes. For the structures with larger shape anisotropy, the switching field distribution/coercivity (SFD/Hc ) was reduced, and for the array with the smallest separations (20 nm and 35 nm along the long and short axes, respectively), coherent rotation of the whole array occurred. The magnitude of both the shape anisotropy and a configurational anisotropy induced by the magnetostatic interactions have been estimated. These results provide some useful information for the design of potential magnetic nanodot logic and for high-density magnetic random access memory
Dynamics near the Surface Reconstruction of W(100)
Using Brownian molecular dynamics simulation, we study the surface dynamics
near the reconstruction transition of W(100) via a model Hamiltonian. Results
for the softening and broadening of the surface phonon spectrum near the
transition are compared with previous calculations and with He atom scattering
data. From the critical behavior of the central peak in the dynamical structure
factor, we also estimate the exponent of the power law anomaly for adatom
diffusion near the transition temperature.Comment: 8 pages, 8 figures, to appear in Phys. Rev.
Exogenous Ca2+ priming can improve peanut photosynthetic carbon fixation and pod yield under early sowing scenarios in the field
Harnessing cold-resilient and calcium-enriched peanut production technology are crucial for high-yielding peanut cultivation in high-latitude areas. However, there is limited field data about how exogenous calcium (Ca2+) application would improve peanut growth resilience during exposure to chilling stress at early sowing (ES). To help address this problem, a two-year field study was conducted to assess the effects of exogenous foliar Ca2+Β application on photosynthetic carbon fixation and pod yield in peanuts under different sowing scenarios. We measured plant growth indexes, leaf photosynthetic gas exchange, photosystems activities, and yield in peanuts. It was indicated that ES chilling stress at the peanut seedling stage led to the reduction of Pn, gs, Tr, Ls, WUE, respectively, and the excessive accumulation of non-structural carbohydrates in leaves, which eventually induced a chilling-dependent feedback inhibition of photosynthesis due mainly to weaken growth/sink demand. While exogenous Ca2+Β foliar application improved the export of nonstructural carbohydrates, and photosynthetic capacity, meanwhile activated cyclic electron flow, thereby enhancing growth and biomass accumulation in peanut seedlings undergoing ES chilling stress. Furthermore, ES combined with exogenous Ca2+Β application can significantly enhance plant chilling resistance and peanut yield ultimately in the field. In summary, the above results demonstrated that exogenous foliar Ca2+Β application restored the ES-linked feedback inhibition of photosynthesis, enhancing the growth/sink demand and the yield of peanuts
Dynamics of false vacuum bubbles: beyond the thin shell approximation
We numerically study the dynamics of false vacuum bubbles which are inside an
almost flat background; we assumed spherical symmetry and the size of the
bubble is smaller than the size of the background horizon. According to the
thin shell approximation and the null energy condition, if the bubble is
outside of a Schwarzschild black hole, unless we assume Farhi-Guth-Guven
tunneling, expanding and inflating solutions are impossible. In this paper, we
extend our method to beyond the thin shell approximation: we include the
dynamics of fields and assume that the transition layer between a true vacuum
and a false vacuum has non-zero thickness. If a shell has sufficiently low
energy, as expected from the thin shell approximation, it collapses (Type 1).
However, if the shell has sufficiently large energy, it tends to expand. Here,
via the field dynamics, field values of inside of the shell slowly roll down to
the true vacuum and hence the shell does not inflate (Type 2). If we add
sufficient exotic matters to regularize the curvature near the shell, inflation
may be possible without assuming Farhi-Guth-Guven tunneling. In this case, a
wormhole is dynamically generated around the shell (Type 3). By tuning our
simulation parameters, we could find transitions between Type 1 and Type 2, as
well as between Type 2 and Type 3. Between Type 2 and Type 3, we could find
another class of solutions (Type 4). Finally, we discuss the generation of a
bubble universe and the violation of unitarity. We conclude that the existence
of a certain combination of exotic matter fields violates unitarity.Comment: 40 pages, 41 figure
Turbulent diffusion and drift in galactic magnetic fields and the explanation of the knee in the cosmic ray spectrum
We reconsider the scenario in which the knee in the cosmic ray spectrum is
explained as due to a change in the escape mechanism of cosmic rays from the
Galaxy from one dominated by transverse diffusion to one dominated by drifts.
We solve the diffusion equations adopting realistic galactic field models and
using diffusion coefficients appropriate for strong turbulence (with a
Kolmogorov spectrum of fluctuations) and consistent with the assumed magnetic
fields. We show that properly taking into account these effects leads to a
natural explanation of the knee in the spectrum, and a transition towards a
heavier composition above the knee is predicted.Comment: 17 pp., 6 figures; revised version with minor changes. To appear in
JHE
Comparison of s- and d-wave gap symmetry in nonequilibrium superconductivity
Recent application of ultrafast pump/probe optical techniques to
superconductors has renewed interest in nonequilibrium superconductivity and
the predictions that would be available for novel superconductors, such as the
high-Tc cuprates. We have reexamined two of the classical models which have
been used in the past to interpret nonequilibrium experiments with some
success: the mu* model of Owen and Scalapino and the T* model of Parker.
Predictions depend on pairing symmetry. For instance, the gap suppression due
to excess quasiparticle density n in the mu* model, varies as n^{3/2} in d-wave
as opposed to n for s-wave. Finally, we consider these models in the context of
S-I-N tunneling and optical excitation experiments. While we confirm that
recent pump/probe experiments in YBCO, as presently interpreted, are in
conflict with d-wave pairing, we refute the further claim that they agree with
s-wave.Comment: 14 pages, 11 figure
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