Effect of the stimulation level on the refractory behavior of the electrically stimulated auditory nerve

The refractory behavior of the electrically stimulated auditory nerve can be described by the recovery function, which plots the ECAP amplitude in response to a masker/probe stimulus pair as a function of the time interval (Masker Probe Interval, MPI) between the two stimuli. The recovery function is characterized by two time intervals or periods: In the first interval (the Absolute Refractory Period, ARP), typically lasting for 300 to 400us, the neurons stimulated by the masker are in absolute refractory and unable to respond to the probe stimulus. As the MPI is gradually increased beyond the ARP, the stimulated neural population is increasingly able to respond to the probe stimulus (i.e. relative refractory) as the inhibitory effects of the masker diminishes. This second interval (the Relative Refractory Period, RRP) can be characterized by the time constant of an asymptotically increasing exponential function (Morsnowski et al. 2006). This recovery time constant provides an indication of the neurons’ temporal characteristics. Previous reports (e.g. Battmer et al. 2004) suggest that this time constant is affected by the stimulation level used to determine the recovery function. Such a dependency would make it difficult to characterize the refractory behavior of the stimulated neurons using the recovery function. In this study, the refractory behavior of the electrically stimulated auditory nerve with respect to stimulation level was examined retrospectively. It was expected that increasing the stimulation level would result in more deterministic behavior

Self-consistent nonlinear kinetic simulations of the anomalous Doppler instability of suprathermal electrons in plasmas

Suprathermal tails in the distributions of electron velocities parallel to the magnetic field are found in many areas of plasma physics, from magnetic confinement fusion to solar system plasmas. Parallel electron kinetic energy can be transferred into plasma waves and perpendicular gyration energy of particles through the anomalous Doppler instability (ADI), provided that energetic electrons with parallel velocities v ≥ (ω + Ωce )/k are present; here Ωce denotes electron cyclotron frequency, ω the wave angular frequency and k the component of wavenumber parallel to the magnetic field. This phenomenon is widely observed in tokamak plasmas. Here we present the first fully self-consistent relativistic particle-in-cell simulations of the ADI, spanning the linear and nonlinear regimes of the ADI. We test the robustness of the analytical theory in the linear regime and follow the ADI through to the steady state. By directly evaluating the parallel and perpendicular dynamical contributions to j · E in the simulations, we follow the energy transfer between the excited waves and the bulk and tail electron populations for the first time. We find that the ratio Ωce /(ωpe + Ωce ) of energy transfer between parallel and perpendicular, obtained from linear analysis, does not apply when damping is fully included, when we find it to be ωpe /(ωpe + Ωce ); here ωpe denotes the electron plasma frequency. We also find that the ADI can arise beyond the previously expected range of plasma parameters, in particular when Ωce > ωpe . The simulations also exhibit a spectral feature which may correspond to observations of suprathermal narrowband emission at ωpe detected from low density tokamak plasmas

Effectiveness of a self-help cognitive behavioural treatment program for problem gamblers: a randomised controlled trial

The study aimed to strengthen the scarce literature on self-help treatments for Problem Gambling (PG) by comparing the effectiveness of a Self-Help Cognitive Behavioral Treatment (SHCBT) program (n\ua0=\ua023) with a 6-week Waitlist condition (n\ua0=\ua032) in problem gamblers. Participants were community volunteers with gambling problems and were randomly allocated to the Waitlist and treatment conditions. Results showed significant improvements at post-treatment in gambling behaviors including frequency of gambling, average amount gambled per day and PG symptoms as well as a number of gambling correlates including psychological states (e.g., depression, anxiety and stress), gambling cognitions, gambling urges, gambling related self-efficacy, satisfaction with life, and quality of life among those who completed the SHCBT program, when compared with the waitlist condition. The effect size (partial η) ranged from .25 to .57 for all assessed outcomes that showed significant improvement from pre- to post-treatment. It was concluded that a self-help CBT program can be beneficial for treating community problem gamblers

Orbital and valley state spectra of a few-electron silicon quantum dot

Understanding interactions between orbital and valley quantum states in silicon nanodevices is crucial in assessing the prospects of spin-based qubits. We study the energy spectra of a few-electron silicon metal-oxide-semiconductor quantum dot using dynamic charge sensing and pulsed-voltage spectroscopy. The occupancy of the quantum dot is probed down to the single-electron level using a nearby single-electron transistor as a charge sensor. The energy of the first orbital excited state is found to decrease rapidly as the electron occupancy increases from N=1 to 4. By monitoring the sequential spin filling of the dot we extract a valley splitting of ~230 {\mu}eV, irrespective of electron number. This indicates that favorable conditions for qubit operation are in place in the few-electron regime.Comment: 4 figure

Melody contour identification and instrument recognition using semitone mapping in Nucleus Cochlear Implant recipients

Cochlear implants (CIs) were originally aimed at restoring speech perception for patients with profound hearing loss. Many postlingually deafened CI patients report that music is not well perceived while others enjoy it. Music consists of complex sounds composed of tones with harmonic structure of overtones and temporal fine structure. The harmonic structure is not preserved by the current standard (Std) ACE (advanced combination encoders) mapping and the temporal fine structure is not well encoded. The mapping is believed to produce distortion due to compression oin the low frequency range. In 2008 we proposed two new semitone (Smt) mappings (Smt-LF and Smt-MF) in two frequency ranges (130-1502 Hz and 440-5040 Hz) respectively (Omran et al. 2008). Smt mapping is expected to preserve the harmonic structure representation of overtones and this may improve melody recognition with CIs. In this paper two psychoacoustic experiments (melody contour identification (MCI) (Galvin et al. 2007) and instrument recognition (IR)) were conducted with three different conditions (Std, Smt-MF and Smt-LF mappings) with CI recipients by streaming processed stimuli directly to the implant. The MCI test included five patterns (rising - rising falling - flat - falling rising – falling). Each pattern consisted of five tones; each tone had a fundamental frequency and four overtones. The lowest fundamental frequency of each pattern is called “root”. Signals had two different roots A3 (220 Hz) and A4 (440 Hz). Proposed nine patterns with three roots (A3, A4 and A5) by Galvin et al. (2007) were examined in a pilot test. This test took a long time and the preliminary results showed a possibility to reduce the number of patterns to five and eliminate the fifth octave root (A5). In the IR test, four pairs of instruments (Trumpet and Trombone, Flute and Clarinet, Violin and Cello, Guitar and Piano) from four groups (Brass, Woodwind, Struck and String instruments) respectively were used. MCI and IR tests were conducted with 8 CI recipients. Results from MCI tests showed an improvement with Smt mapping in respect to Std mapping or at least similar results. However, wrong identification occurred with notes having filtered out partials. CI recipients showed an increase in identifying melody contour patterns with Smt mappings. Instrument identification performance decreased with semitone mappings

Evidence for Strain-Induced Local Conductance Modulations in Single-Layer Graphene on SiO_2

Graphene has emerged as an electronic material that is promising for device applications and for studying two-dimensional electron gases with relativistic dispersion near two Dirac points. Nonetheless, deviations from Dirac-like spectroscopy have been widely reported with varying interpretations. Here we show evidence for strain-induced spatial modulations in the local conductance of single-layer graphene on SiO_2 substrates from scanning tunneling microscopic (STM) studies. We find that strained graphene exhibits parabolic, U-shaped conductance vs bias voltage spectra rather than the V-shaped spectra expected for Dirac fermions, whereas V-shaped spectra are recovered in regions of relaxed graphene. Strain maps derived from the STM studies further reveal direct correlation with the local tunneling conductance. These results are attributed to a strain-induced frequency increase in the out-of-plane phonon mode that mediates the low-energy inelastic charge tunneling into graphene

Innermost Stable Circular Orbit of a Spinning Particle in Kerr Spacetime

We study stability of a circular orbit of a spinning test particle in a Kerr spacetime. We find that some of the circular orbits become unstable in the direction perpendicular to the equatorial plane, although the orbits are still stable in the radial direction. Then for the large spin case ($S < \sim O(1)), the innermost stable circular orbit (ISCO) appears before the minimum of the effective potential in the equatorial plane disappears. This changes the radius of ISCO and then the frequency of the last circular orbit.Comment: 25 pages including 8 figure