The effects on arterial haemoglobin oxygen saturation and on shunt of increasing cardiac output with dopamine or dobutamine during one-lung ventilation

Publisher's copy made available with the permission of the publisher © Australian Society of AnaesthetistsTheoretically, if the cardiac output were increased in the presence of a given intrapulmonary shunt, the arterial saturation should improve as the venous oxygen extraction per ml of blood decreases if the total oxygen consumption remains constant. Previous work demonstrated that this was not achieved with adrenaline or isoprenaline as increased shunting negated any benefit from improved cardiac output and mixed venous oxygen content. However, pharmacological stimulation of cardiac output and venous oxygen without any increase in shunt should achieve the goal of improved arterial oxygenation. To test this hypothesis, seven pigs were subjected to one-lung ventilation and infused on separate occasions, with dopamine and with dobutamine in random order to increase the cardiac output. The mixed venous oxygen content, shunt fraction, oxygen consumption and arterial oxygen saturation were measured. With both dopamine and dobutamine there was a consistent rise in venous oxygen content. However, with dopamine, the mean shunt rose from 28% to 42% and with dobutamine, the mean shunt rose from 45% to 59% (both changes P<0.01). With dopamine, the mean arterial oxygen saturation fell by 4.7%, and with dobutamine by 2.9%, but neither fall was statistically significant. It is concluded that any benefit to arterial saturation which might occur from a dopamine- or dobutamine-induced increase in mixed venous oxygen content during one-lung ventilation is offset by increased shunting. During one-lung anaesthesia, there would appear to be no benefit to arterial saturation in increasing cardiac output with an infusion of either dopamine or dobutamine.W. J. Russell, M. F. Jameshttp://www.aaic.net.au/Article.asp?D=200331

Client/server : what exactly is the problem?

Includes bibliographical references.Various organizations have made a commitment to migrate their systems to a new client/server architecture. Due to it's diverse nature, many problems have arisen inherent to the way the system works. For instance, the use of different tools and platforms to accomplish various tasks is required. Getting these tools to work well together in disparate situations is a key issue. How can a company determine which tools, platforms, and systems changes are desired? One way to do this is to communicate; share the information concerning the problems one encounters with others who find themselves in the same boat. Therefore, a survey was distributed focusing within six facets of client/server application development: performance, capacity, scalability, portability, connectivity, and functionality. The objective: to discover various common links and/or connections that contribute to successful client/server application development The result: information was gathered from the people who are out there right now producing it. The four page survey was disseminated to over 500 information systems professionals throughout the domestic United States. Participants were selected by the respondent's title( manager or director of MIS or Systems & Programming), the corporation's listed systems, and were obtained from the Spring 1995 Computing IS Managers Guide. The design of the survey was critical in obtaining specific, relevant information. Utilizing the inverted funnel sequencing style, the task of getting a given respondent to open up was accomplished. The respondent contributed the answers as opposed to the survey suggesting them. 15% of the surveys (74 of 500) were returned; 40 of which the respondent indicated no background in client/server and 34 of which were completed in full. Through analysis of these surveys, I have gained a greater appreciation for exactly how diverse client/server really is. I was able to discover some common threads in each area. This paper is an excellent starting point to further analyze client/server problem areas.B.S. (Bachelor of Science

Closed loop spray cooling apparatus

A closed loop apparatus for spraying coolant against the back of a radiation target is described. The coolant was circulated through a closed loop with a bubble of inert gas being maintained around the spray. Mesh material was disposed between the bubble and the surface of the liquid coolant which was below the bubble at a predetermined level. In a second embodiment, no inert gas was used, the bubble consisting of a vapor produced when the coolant was sprayed against the target

Developments in Federal Water Policies and Programs

14 pages

Design of a low cost earth resources system

The author has identified the following significant results. Survey results indicated that users of remote sensing data in the Southeastern U.S. were increasingly turning to digital processing techniques. All the states surveyed have had some involvement in projects using digitally processed data. Even those states which do not yet have in-house capabilities for digital processing were extremely interested in and were planning to develop such capabilities

Computer processing of peach tree decline data

There are no author-identified significant results in this report

Master Equation for Hydrogen Recombination on Grain Surfaces

Recent experimental results on the formation of molecular hydrogen on astrophysically relevant surfaces under conditions similar to those encountered in the interstellar medium provided useful quantitative information about these processes. Rate equation analysis of experiments on olivine and amorphous carbon surfaces provided the activation energy barriers for the diffusion and desorption processes relevant to hydrogen recombination on these surfaces. However, the suitability of rate equations for the simulation of hydrogen recombination on interstellar grains, where there might be very few atoms on a grain at any given time, has been questioned. To resolve this problem, we introduce a master equation that takes into account both the discrete nature of the H atoms and the fluctuations in the number of atoms on a grain. The hydrogen recombination rate on microscopic grains, as a function of grain size and temperature, is then calculated using the master equation. The results are compared to those obtained from the rate equations and the conditions under which the master equation is required are identified.Comment: Latex document. 14 pages of text. Four associated figs in in PS format on separate files that are "called-in" the LaTeX documen

Formation of plasma around a small meteoroid: 1. Kinetic theory

This article is a companion to Dimant and Oppenheim [2017] https://doi.org/10.1002/2017JA023963.This paper calculates the spatial distribution of the plasma responsible for radar head echoes by applying the kinetic theory developed in the companion paper. This results in a set of analytic expressions for the plasma density as a function of distance from the meteoroid. It shows that at distances less than a collisional mean free path from the meteoroid surface, the plasma density drops in proportion to 1/R where R is the distance from the meteoroid center; and, at distances much longer than the mean‐free‐path behind the meteoroid, the density diminishes at a rate proportional to 1/R2. The results of this paper should be used for modeling and analysis of radar head echoes.This work was supported by NSF grant AGS-1244842. (AGS-1244842 - NSF

The effects on increasing cardiac output with adrenaline or isoprenaline on arterial haemoglobin oxygen saturation and shunt during one-lung ventilation

Publisher's copy made available with the permission of the publisher © 2000 Australian Society of AnaesthetistsTheoretically, if the cardiac output were increased in the presence of a given intrapulmonary shunt, the arterial haemoglobin oxygen saturation (SaO2) should improve as the venous oxygen extraction per ml of blood decreases. To test this hypothesis, eight pigs were subjected to one-lung ventilation and adrenaline and isoprenaline infusions used to increase the cardiac output. The mixed venous oxygen, shunt fraction and oxygen consumption were measured. With both adrenaline and isoprenaline, although there was a small rise in mixed venous oxygen content, there was a fall in SaO2. With adrenaline, the mean shunt rose from 48% to 65%, the mean oxygen consumption rose from 126 ml/min to 134 ml/min and the mean SaO2 fell from 86.9% to 82.5%. With isoprenaline, the mean shunt rose from 45% to 59%, the mean oxygen consumption rose from 121 ml/min to 137 ml/min and the mean SaO2 fell from 89.5% to 84.7%. It is concluded that potential improvement in SaO2, which might occur from a catecholamine-induced increase in mixed venous oxygen content during one-lung ventilation, is more than offset by increased shunting and oxygen consumption which reduce SaO2.W.J. Russell, M.F. Jameshttp://www.aaic.net.au/Article.asp?D=200010