130 research outputs found
Liposomi rivastigmina za isporuku u mozak intranazalnim putem
The present study is mainly aimed at delivering a drug into the brain via the intranasal route using a liposomal formulation. For this purpose, rivastigmine, which is used in the management of Alzheimer’s disease, was selectd as a model drug. Conventional liposomes were formulated by lipid layer hydration method using cholesterol and soya lecithin as lipid components. The concentration of rivastigmine in brain and plasma was studied in rat models after intranasal and oral administration of liposomes and free drug. A significantly higher level of drug was found in the brain with intranasal liposomes of rivastigmine compared to the intranasal free drug and the oral route. Intranasal liposomes had a longer half-life in the brain than intranasally or orally administered free drug. Delivering rivastigmine liposomes through the intranasal route for the treatment of Alzheimer’s disease might be a new approach to the management of this condition.Glavni cilj rada je razvoj liposoma za intranazalnu primjenu za isporuku lijeka u mozak. U tu svrhu izabran je rivastigmin kao modelni lijek koji se upotrebljava u terapiji Alzheimerove bolesti. Liposomi su pripravljeni metodom hidratacije lipidnog sloja koristeći kolesterol i lecitin iz soje kao lipidne komponente. Praćena je koncentracija rivastigmina u mozgu i plazmi nakon intranazalne i peroralne primjene liposoma i slobodnog lijeka. S intranazalnim liposomima rivastigmina postignuta je značajno veća koncentracija lijeka u mozgu. Osim toga intranazalni liposomi imaju dulje vrijeme poluživota u mozgu. Intranazalna primjena liposoma rivastigmina mogla bi predstavljati novi pristup terapiji Alzheimerove bolesti
Connective Memory Work on Justice for Mike Brown
This chapter addresses what I term the "connective memory work" carried out on Facebook page dedicated to achieving justice for Michael Brown, an African America teenager whose death at the gun of white police officer Darren Wilson in early August 2014 led to the Ferguson protests. The chapter outlines four types of connective memory work evident on the page. These types include the ‘memetic resurrection’ that involved the appropriation of iconic historical imagery alongside those of networked commemoration, digital archiving and curation, and crowd reconstruction. Central to this contribution the call to rethink the digital memory work practices of activists so as to integrate a concern for the agency of social media platforms themselves.<br/
Systematic review, network meta-analysis and economic evaluation of biological therapy for the management of active psoriatic arthritis
Psoriatic arthritis in patients with psoriasis: evaluation of clinical and epidemiological features in 133 patients followed at the University Hospital of Brasília
Functional impairment of systemic scleroderma patients with digital ulcerations: Results from the DUO registry
Demographic, clinical and antibody characteristics of patients with digital ulcers in systemic sclerosis: data from the DUO Registry
OBJECTIVES: The Digital Ulcers Outcome (DUO) Registry was designed to describe the clinical and antibody characteristics, disease course and outcomes of patients with digital ulcers associated with systemic sclerosis (SSc).
METHODS: The DUO Registry is a European, prospective, multicentre, observational, registry of SSc patients with ongoing digital ulcer disease, irrespective of treatment regimen. Data collected included demographics, SSc duration, SSc subset, internal organ manifestations, autoantibodies, previous and ongoing interventions and complications related to digital ulcers.
RESULTS: Up to 19 November 2010 a total of 2439 patients had enrolled into the registry. Most were classified as either limited cutaneous SSc (lcSSc; 52.2%) or diffuse cutaneous SSc (dcSSc; 36.9%). Digital ulcers developed earlier in patients with dcSSc compared with lcSSc. Almost all patients (95.7%) tested positive for antinuclear antibodies, 45.2% for anti-scleroderma-70 and 43.6% for anticentromere antibodies (ACA). The first digital ulcer in the anti-scleroderma-70-positive patient cohort occurred approximately 5 years earlier than the ACA-positive patient group.
CONCLUSIONS: This study provides data from a large cohort of SSc patients with a history of digital ulcers. The early occurrence and high frequency of digital ulcer complications are especially seen in patients with dcSSc and/or anti-scleroderma-70 antibodies
The Tourism Supply Linkage: Recreational Sites and their Related Natural Amenities
While the demand aspects of publicly provided recreation and tourism-related travel
have long held the spotlight of research, the supply or production side remains inexact and
relatively unexplored. In this manuscript, we focus on supply components of recreational resources
and their links with tourism incidence in Wisconsin. The supply of recreation and
tourism is a complex combination of natural amenities, recreational sites, access, and private
sector business activity which is influenced by an array of factors that act to provide opportunities
that satisfy leisure-based travel demands. Measures of recreational site density that account
for both physical/geographic size and population, or social capacity are used as key explanatory
variables in models of tourism dependence. Results suggest that tourism dependence
in Wisconsin involves both recreation sites and natural amenities. Assessing tourism production
without incorporation of these non-priced latent inputs provides an incomplete characterization
of the tourism phenomenon
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