3,661 research outputs found

    Enhancing Christian School Experiences for Pre-Service Teachers through Service-Learning Partnerships

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    The mission of the Teacher Licensure Program at Liberty University is to develop competent professionals with a Christian worldview for Christian, public, and private schools. To be consistent with the mission, classroom experience in both Christian and public schools should be required for each teacher candidate who successfully completes Liberty’s program. One of the challenges in the implementation of the mission has been an inadequate number of field experience placements available in Christian school settings

    Enhancing Christian School Field Experiences through Academic Coaching in a Service-learning Partnership

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    This article gives an overview of service learning as it relates to learning and understanding a college student’s field of study. A survey was given to our education candidates who were completing a service learning project in a local Christian school. Results from the survey indicate that students were more likely to work in Christian school after having been exposed to this experience

    Multidimensional mutual information methods for the analysis of covariation in multiple sequence alignments

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    Several methods are available for the detection of covarying positions from a multiple sequence alignment (MSA). If the MSA contains a large number of sequences, information about the proximities between residues derived from covariation maps can be sufficient to predict a protein fold. If the structure is already known, information on the covarying positions can be valuable to understand the protein mechanism. In this study we have sought to determine whether a multivariate extension of traditional mutual information (MI) can be an additional tool to study covariation. The performance of two multidimensional MI (mdMI) methods, designed to remove the effect of ternary/quaternary interdependencies, was tested with a set of 9 MSAs each containing <400 sequences, and was shown to be comparable to that of methods based on maximum entropy/pseudolikelyhood statistical models of protein sequences. However, while all the methods tested detected a similar number of covarying pairs among the residues separated by < 8 {\AA} in the reference X-ray structures, there was on average less than 65% overlap between the top scoring pairs detected by methods that are based on different principles. We have also attempted to identify whether the difference in performance among methods is due to different efficiency in removing covariation originating from chains of structural contacts. We found that the reason why methods that derive partial correlation between the columns of a MSA provide a better recognition of close contacts is not because they remove chaining effects, but because they filter out the correlation between distant residues that originates from general fitness constraints. In contrast we found that true chaining effects are expression of real physical perturbations that propagate inside proteins, and therefore are not removed by the derivation of partial correlation between variables.Comment: 21 pages, 4 figures, 1 table, supporting information containing 2 additional figures is included at the end of the manuscrip

    Analysis of Expression Pattern and Genetic Deletion of Netrin5 in the Developing Mouse

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    Boundary cap cells are a transient, neural-crest-derived population found at the motor exit point and dorsal root entry zone of the embryonic spinal cord. These cells contribute to the central/peripheral nervous system boundary, and in their absence neurons and glia from the CNS migrate into the PNS. We found Netrin5 (Ntn5), a previously unstudied member of the netrin gene family, to be robustly expressed in boundary cap cells. We generated Ntn5 knockout mice and examined neurodevelopmental and boundary-cap-cell-related phenotypes. No abnormalities in cranial nerve guidance, dorsal root organization, or sensory projections were found. However, Ntn5 mutant embryos did have ectopic motor neurons that migrated out of the ventral horn and into the motor roots. Previous studies have implicated semaphorin6A (Sema6A) in boundary cap cells signaling to plexinA2 (PlxnA2)/neuropilin2 (Nrp2) in motor neurons in restricting motor neuron cell bodies to the ventral horn, particularly in the caudal spinal cord. In Ntn5 mutants, ectopic motor neurons are likely to be a different population, as more ectopias were found rostrally. Furthermore, ectopic motor neurons in Ntn5 mutants were not immunoreactive for NRP2. The netrin receptor DCC is a potential receptor for NTN5 in motor neurons, as similar ectopic neurons were found in Dcc mutant mice, but not in mice deficient for other netrin receptors. Thus, Ntn5 is a novel netrin family member that is expressed in boundary cap cells, functioning to prevent motor neuron migration out of the CNS

    CIMSS FIRE research activities

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    An overview of the Cooperative Institute for Meteorological Satellite Studies' FIRE research activities is presented. Emphasis is on the analysis of the High-Resolution Interferometer Sounder (HIS) made from the ER-2 as well as ground based measurements made by the Atmospheric Emitted Radiance Interferometer (AERI) prototype

    Mental Health Service Providers: College Student Perceptions of Helper Effectiveness

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    Undergraduate perceptions of the overall effectiveness of six types of mental health service providers (MHSPs) were obtained with a survey. Although many mental health services are available to consumers in the United States, research has indicated that these services are underutilized. Perceptions have been linked to therapeutic outcomes and may potentially serve as barriers to treatment. The results of the present study illustrate a range of perceptions and highlight the value of educating future consumers and practitioners about the roles of various MHSPs in providing mental health services. Future research is proposed

    Cirrus cloud retrievals from HIS observations during FIRE 2

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    This paper presents retrieval methods applied to HIS observations during FIRE II and doubling/adding model developed to simulate high-spectral resolution infrared radiances in a cloudy atmosphere. The capabilities of the retrieval methods and sensitivity studies of high-altitude aircraft based observations to cloud microphysical structure are conducted with the model

    Homogeneity and Heterogeneity as Situational Properties: Producing – and Moving Beyond? – Race in Post-Genomic Science

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    In this article, we explore current thinking and practices around the logics of difference in gene–environment interaction research in the post-genomic era. We find that scientists conducting gene–environment interaction research continue to invoke well-worn notions of racial difference and diversity, but use them strategically to try to examine other kinds of etiologically significant differences among populations. Scientists do this by seeing populations not as inherently homogeneous or heterogeneous, but rather by actively working to produce homogeneity along some dimensions and heterogeneity along others in their study populations. Thus we argue that homogeneity and heterogeneity are situational properties – properties that scientists seek to achieve in their study populations, the available data, and other aspects of the research situation they are confronting, and then leverage to advance post-genomic science. Pointing to the situatedness of homogeneity and heterogeneity in gene–environment interaction research underscores the work that these properties do and the contingencies that shape decisions about research procedures. Through a focus on the situational production of homogeneity and heterogeneity more broadly, we find that gene–environment interaction research attempts to shift the logic of difference from solely racial terms as explanatory ends unto themselves, to racial and other dimensions of difference that may be important clues to the causes of complex diseases

    Delayed presentation of a traumatic scalp arteriovenous fistula

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    Background: Arteriovenous (AV) fistulas of the scalp are extracranial vascular malformations commonly caused by trauma and typically present within 3 years. Although they follow a benign course, they can be esthetically displeasing. Case description: We present an atypical onset of scalp AV fistula in a patient with a 1-year history of the left-sided pulsatile tinnitus and scalp swelling 7 years after a traumatic epidural hematoma evacuation. Our patient was found to have an 8 mm AV fistula supplied by the deep temporal artery. Endovascular embolization was performed using eight coils. There was no complication from the procedure, and the patient's pulsatile tinnitus and swelling resolved immediately after embolization. Follow-up angiogram demonstrated complete obliteration of the AV fistula. Conclusion: Delayed presentation of traumatic scalp AV fistula is very rare, and it is important to keep this in the differential in patients with scalp swelling after head trauma

    Anisotropic flow in 4.2A GeV/c C+Ta collisions

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    Anisotropic flow of protons and negative pions in 4.2A GeV/c C+Ta collisions is studied using the Fourier analysis of azimuthal distributions. The protons exhibit pronounced directed flow. Directed flow of pions is positive in the entire rapidity interval and indicates that the pions are preferentially emitted in the reaction plane from the target to the projectile. The elliptic flow of protons and negative pions is close to zero. Comparison with the quark-gluon-string model (QGSM) and relativistic transport model (ART 1.0) show that they both yield a flow signature similar to the experimental data.Comment: 4 pages, 3 figures, Accepted for publication in Phys. Rev.
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