Gain spectroscopy of a type-II VECSEL chip

Using optical pump-white light probe spectroscopy the gain dynamics is investigated for a VECSEL chip which is based on a type-II heterostructure. The active region the chip consists of a GaAs/(GaIn)As/Ga(AsSb)/(GaIn)As/GaAs multiple quantum well. For this structure, a fully microscopic theory predicts a modal room temperature gain at a wavelength of 1170 nm, which is confirmed by experimental spectra. The results show a gain buildup on the type-II chip which is delayed relative to that of a type-I chip. This slower gain dynamics is attributed to a diminished cooling rate arising from reduced electron-hole scattering.Comment: 4 pages, 4 figure

Online Consultations Between General Practitioners and Psychiatrists in the Netherlands:A Qualitative Study

Objective: To examine the nature and scope of questions about psychiatric patient cases submitted by general practitioners (GPs) to an established online consultation platform and to determine if they could have been answered by consulting existing clinical guidelines. Methods: All anonymized psychiatric cases submitted by GPs to the online electronic Prisma platform between September 2018 and November 2019 were examined in a mixed-methods study. Descriptive statistics and qualitative thematic analysis were used, followed by axial coding to arrive at overarching themes to characterize cases. Results: Of the 136 included cases, 44.1% concerned female patients and about half concerned patients aged 31–60 years. Common psychiatric disorders were depression, attention deficit hyperactivity disorder, sleeping problems, sexual disorders, and eating disorders. The first response was usually given within 2 h (interquartile range, 0–14.3 h), with 86% answered within 24 h and 95% within 48 h. Qualitative analysis revealed four themes, namely “type of question,” “cases in relation to current clinical guidelines,” “case complexity” and “the doctor being pressured.” Type of question comprised diagnostic, therapeutic, and referral questions. Notably, for 44.1% of questions no current clinical guidelines was present and 46.3% of cases were deemed complex in nature. GPs were willing to share their experiences of coping with being pressured by patients. Conclusion: The findings of this study support the potential for an online electronic consultation platform to facilitate feasible and useful interprofessional consultation between GPs and psychiatrists for a broad range mental illnesses and questions of varying complexity

Snowmass 2001: Jet Energy Flow Project

Conventional cone jet algorithms arose from heuristic considerations of LO hard scattering coupled to independent showering. These algorithms implicitly assume that the final states of individual events can be mapped onto a unique set of jets that are in turn associated with a unique set of underlying hard scattering partons. Thus each final state hadron is assigned to a unique underlying parton. The Jet Energy Flow (JEF) analysis described here does not make such assumptions. The final states of individual events are instead described in terms of flow distributions of hadronic energy. Quantities of physical interest are constructed from the energy flow distribution summed over all events. The resulting analysis is less sensitive to higher order perturbative corrections and the impact of showering and hadronization than the standard cone algorithms.Comment: REVTeX4, 13 pages, 6 figures; Contribution to the P5 Working Group on QCD and Strong Interactions at Snowmass 200

Developing Berkshire Market Pig Growth Curves

Several factors have stimulated interest in an old, rather minor swine breed, Berkshire pigs. Berkshires produce pork that is darker, with more intramuscular fat than most swine breeds and lines currently. As the majority of modern pigs were genetically selected to be leaner, the Berkshire breed has continued to produce more flavorful pork. Asian consumers, especially Japanese, prefer and will pay a premium for Berkshire pork. American chefs and discriminating consumers request Berkshire pork, a strong market demand that has caused a flourish in the pork niche market largely centered around pork from Berkshirebred pigs. Some Iowa pork producers are raising Berkshire or Berkshire-cross pigs exclusively for export and niche markets. Several Berkshire niche markets and marketers are currently active in Iowa. Many of these markets require that the pigs must be reared in bedded or outdoor settings. A popular housing system used in Iowa is the bedded hoop barn

Lean and Fat Deposition Measurements for Purebred Berkshire Pigs Housed in Hoop Barns in Iowa

Previous research on meat quality of pork has demonstrated that purebred Berkshires have advantages over most commodity based pork. Therefore a Certified Berkshire Pork program has developed and is a vital niche market in Iowa and the United States that provides economic opportunity for a growing number of producers. This research has also documented that Berkshires have a significantly poorer feed conversion than other breeds, thus raising their cost of production. Understanding how feed programs and growth rates affect lean and fat deposition rates is a critical aspect to these niche programs in order to maximize profitability and quality of the Berkshire pork products marketed. From these two trials there are differences between the two trials for both barrows and gilts that may not be accounted for by seasonal affects. Overall, barrows averaged an inch of backfat between 200 and 240 lb body weight whereas gilts approached this backfat depth between 260 and 300 lb. Lean deposition rates were different between barrows and gilts and between trials. This difference makes it critical when selecting animals for marketing and achieving consistency in meat quality within a marketing system. The differences between barrows and gilts indicate it may be more critical that each are fed differently than in commercial production systems

Feed Intake and Growth Rate in Purebred Berkshire Pigs Housed in Hoop Buildings in Iowa

Niche marketing continues to grow in Iowa and the United States as the demand for high quality pork increases for both in home and out of home consumption. The majority of pigs in demand for these markets are Berkshires, with many raised in bedded hoop barns. Berkshires have been shown to have significant advantages in meat eating quality, with significantly poorer feed conversion and higher feed costs. However very little information exists as to how these pigs grow and the nutritional needs to optimize both growth and feed efficiency. Producers have little production data to evaluate and adjust feeding programs. These trials were initiated to help characterize these parameters and allow Berkshire producers a means to be more effective within their production and marketing system. This trial demonstrated that Berkshire pigs grow as fast but consume more feed than expected from traditional commodity genetic lines, resulting in a challenging feed conversion ratio. Barrows grow faster, consumed more feed than gilts, but gilts were more efficient converting feed to gain. Although seasonal feed intakes differ for both sexes, growth rates were similar within gilts and barrows. This information can perhaps be used in designing rations and feed budgeting systems that can lower the feed costs for production of Berkshire pork

FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal: protein kinase B–enhanced cell survival through maintenance of mitochondrial integrity

Survival signals elicited by cytokines include the activation of phosphatidylinositol 3-kinase (PI3K), which in turn promotes the activation of protein kinase B (PKB). Recently, PKB has been demonstrated to phosphorylate and inactivate forkhead transcription factor FKHR-L1, a potent inducer of apoptosis. To explore the mechanisms underlying the induction of apoptosis after cytokine withdrawal or FKHR-L1 activation, we used a cell line in which FKHR-L1 activity could be specifically induced. Both cytokine withdrawal and FKHR-L1 activation induced apoptosis, which was preceded by an upregulation in p27KIP1 and a concomitant decrease in cells entering the cell cycle. Induction of apoptosis by both cytokine withdrawal and activation of FKHR-L1 correlated with the disruption of mitochondrial membrane integrity and cytochrome c release. This was preceded by upregulation of the pro-apoptotic Bcl-2 family member Bim. Ectopic expression of an inhibitory mutant of FKHR-L1 substantially reduced the levels of apoptosis observed after cytokine withdrawal. Activation of PKB alone was sufficient to promote cell survival, as measured by maintenance of mitochondrial integrity and the resultant inhibition of effector caspases. Furthermore, hematopoietic stem cells isolated from Bim−/− mice exhibited reduced levels of apoptosis upon inhibition of PI3K/PKB signaling

The impact of a history of child abuse on cognitive performance:a cross-sectional study in older patients with a depressive, anxiety, or somatic symptom disorder

Background: Child abuse is a major global burden with an enduring negative impact on mental and physical health. A history of child abuse is consistently associated with worse cognitive performance among adults; data in older age groups are inconclusive. Since affective symptoms and cognitive functioning are interrelated among older persons, a synergistic effect can be assumed in patients with affective symptoms who also have suffered from child abuse. This study examines the association between a history of child abuse and cognitive performance in such patients. Methods: Cross-sectional data were collected from the ‘Routine Outcome Monitoring for Geriatric Psychiatry & Science’ project, including 179 older adults (age 60–88 years) with either a unipolar depressive, any anxiety, or somatic symptom disorder referred to specialized geriatric mental health care. A history of physical, sexual, and psychological abuse, and emotional neglect was assessed with a structured interview. Cognitive functioning was measured with three paper and pencils tests (10-words verbal memory test, Stroop Colour-Word test, Digit Span) and four tests from the computerized Cogstate Test Battery (Detection Test, Identification Test, One Card Learning Test, One Back Test). The association between a history of child abuse and cognitive performance was examined by multiple linear regression analyses adjusted for covariates. Results: Principal component analyses of nine cognitive parameters revealed four cognitive domains, i.e., visual-verbal memory, psychomotor speed, working memory and interference control. A history of child abuse was not associated with any of these cognitive domains. However, when looking at the specific types of child abuse separately, a history of physical abuse and emotional neglect were associated with poorer interference control. A history of physical abuse was additionally associated with better visual-verbal memory. Conclusions: The association between a history of child abuse and cognitive performance differs between the different types of abuse. A history of physical abuse might particularly be a key determinant of cognitive performance in older adults with a depressive, anxiety, or somatic symptom disorder. Future studies on the impact of these disorders on the onset of dementia should take child abuse into account. Trial registration: ROM-GPS is registered at the Dutch Trial Register (NL6704 at www.trialregister.nl)

The importance of cardiovascular disease for mortality in patients with COPD: a prognostic cohort study

Background. Cardiovascular diseases are the major cause of mortality in patients with chronic obstructive pulmonary disease (COPD), however, are rarely considered in prediction models in patients with COPD. Objective. To quantify the effect of cardiovascular determinants on mortality in patients with a GP's diagnosis of COPD. Methods. Four hundred and five patients aged >65 years with a diagnosis of COPD (244 with COPD by spirometry) were followed up for an average period of 4.2 (SD 1.4) years. Cox proportional hazard regression analyses with bootstrapping techniques were performed to identify independent predictors of all-cause mortality. Results. In multivariable analysis, all-cause mortality was best predicted by age [hazard ratio Conclusions. Physicians should consider ischaemic heart disease in the clinical evaluation of any patient with a GP's diagnosis of COPD. Angina pectoris on history taking is a strong predictor of all-cause mortality in these patients and should be treated adequately to improve prognosis