Effect of PolyGlycopleX (PGX) consumption on blood lipid profiles in healthy, Low CVD risk overweight adults

Raised blood lipid levels are associated with a risk of a cardiovascular disease (CVD). Moderate reductions in several CVD factors such as total, low-density lipoprotein (LDL) cholesterol and non-high-density lipoprotein (non-HDL) cholesterol concentrations may be more effective in reducing overall risk than a major reduction in just one. A blind, randomised controlled trial was conducted with 120 healthy overweight (BMI 25–30) adults aged 25–70 years who were non-smokers, not diabetic and of low risk of cardiovascular disease, as assessed by the Framingham risk equation. Participants consumed 4.5 g PolyGlycopleX (PGX) as softgel capsules (PGXS) or 5 g PGX granules (PGXG) or 5 g rice flour (RF) with meals three times a day for 12 weeks. Total, LDL and non-HDL cholesterol were all significantly reduced (−6%, −5% and −3.5%, respectively) post the PGX granule treatment; however, PGX in softgel capsule form did not affect blood lipid profiles. Daily consumption of PGX granules in overweight low CVD risk adults produced lipid changes indicating a CVD preventative benefit

Complete positivity of nonlinear evolution: A case study

Simple Hartree-type equations lead to dynamics of a subsystem that is not completely positive in the sense accepted in mathematical literature. In the linear case this would imply that negative probabilities have to appear for some system that contains the subsystem in question. In the nonlinear case this does not happen because the mathematical definition is physically unfitting as shown on a concrete example.Comment: extended version, 3 appendices added (on mixed states, projection postulate, nonlocality), to be published in Phys. Rev.

Search for Millicharged Particles at SLAC

Particles with electric charge q < 10^(-3)e and masses in the range 1--100 MeV/c^2 are not excluded by present experiments. An experiment uniquely suited to the production and detection of such "millicharged" particles has been carried out at SLAC. This experiment is sensitive to the infrequent excitation and ionization of matter expected from the passage of such a particle. Analysis of the data rules out a region of mass and charge, establishing, for example, a 95%-confidence upper limit on electric charge of 4.1X10^(-5)e for millicharged particles of mass 1 MeV/c^2 and 5.8X10^(-4)e for mass 100 MeV/c^2.Comment: 4 pages, REVTeX, multicol, 3 figures. Minor typo corrected. Submitted to Physical Review Letter

Consistency, Amplitudes and Probabilities in Quantum Theory

Quantum theory is formulated as the only consistent way to manipulate probability amplitudes. The crucial ingredient is a consistency constraint: if there are two different ways to compute an amplitude the two answers must agree. This constraint is expressed in the form of functional equations the solution of which leads to the usual sum and product rules for amplitudes. A consequence is that the Schrodinger equation must be linear: non-linear variants of quantum mechanics are inconsistent. The physical interpretation of the theory is given in terms of a single natural rule. This rule, which does not itself involve probabilities, is used to obtain a proof of Born's statistical postulate. Thus, consistency leads to indeterminism. PACS: 03.65.Bz, 03.65.Ca.Comment: 23 pages, 3 figures (old version did not include the figures