568 research outputs found
Capitalizing and Depreciating Cyclical Aircraft Maintenance Costs: More-Trouble-Than-It\u27s-Worth?
Restating Capitalization Standards and Rules: The Case for Rough Justice Regulations (Part Two)
Restating Capitalization Standards and Rules: The Case for Rough Justice Regulations (Part One)
Evidence for a Novel, Caspase-8-Independent, Fas Death Domain-Mediated Apoptotic Pathway
Certain caspase-8 null cell lines demonstrate resistance to Fas-induced apoptosis, indicating that the Fas/FasL apoptotic pathway may be caspase-8-dependent. Some reports, however, have shown that Fas induces cell death independent of caspase-8. Here we provide evidence for an alternative, caspase-8-independent, Fas death domain-mediated apoptotic pathway. Murine 12B1-D1 cells express procaspase-3, -8, and -9, which were activated upon the dimerization of Fas death domain. Bid was cleaved and mitochondrial transmembrane potential was disrupted in this apoptotic process. All apoptotic events were completely blocked by the broad-spectrum caspase inhibitor Z-VAD-FMK, but not by other peptide caspase inhibitors. Cyclosporin A (CsA), which inhibits mitochondrial transition pore permeability, blocked neither pore permeability disruption nor caspase activation. However, CsA plus caspase-8 inhibitor blocked all apoptotic events of 12B1-D1 induced by Fas death domain dimerization. Our data therefore suggest that there is a novel, caspase-8-independent, Z-VAD-FMK-inhibitable, apoptotic pathway in 12B1-D1 cells that targets mitochondria directly
Surface Grafting of Poly(L-glutamates). 3. Block Copolymerization
This paper describes for the first time the synthesis of surface-grafted AB-block copolypeptides, consisting of poly(γ-benzyl L-glutamate) (PBLG) as the A-block and poly(γ-methyl L-glutamate) (PMLG) as the B-block. Immobilized primary amine groups of (γ-aminopropyl)triethoxysilane (APS) on silicon wafers initiated the ring-opening polymerization of N-carboxyanhydrides of glutamic acid esters (NCAs). After removal of the BLG-NCA monomer solution after a certain reaction time, the amine end groups of the formed PBLG blocks acted as initiators for the second monomers. This method provides the possibility of making layered structures of surface-grafted block copolymers with tuned properties. Ellipsometry and small-angle X-ray reflection (SAXR) measurements revealed the thickness of the polypeptide layers ranging from 45-100 Å of the first block to 140-270 Å for the total block copolypeptides. The chemical composition of the blocks was determined by X-ray photoelectron spectroscopy (XPS). In addition, Fourier transform infrared transmission spectroscopy (FT-IR) revealed that the polypeptide main chains of both blocks consisted of pure R-helices. The average orientation of the helices ranging from 22-42° with respect to the substrate within the first block to 31-35° in the second block could be derived with FT-IR as well.
Wildlife abundance and diversity as indicators of tourism potential in Northern Botswana
Wildlife tourism can provide economic incentives for conservation. Due to the abundance of
wildlife and the presence of charismatic species some areas are better suited to wildlife
tourism. Our first objective was to develop criteria based on wildlife abundance and diversity
to evaluate tourism potential in the Northern Conservation Zone of Botswana. Secondly we
wanted to quantify and compare tourism experiences in areas with high and low tourism
potential. We used aerial survey data to estimate wildlife biomass and diversity to determine
tourism potential, while data from ground surveys quantified the tourist experience. Areas
used for High Paying Low Volume tourism had significantly higher mean wildlife biomass
and wildlife diversity than the areas avoided for this type of tourism. Only 22% of the Northern
Conservation Zone has intermediate to high tourism potential. The areas with high tourism
potential, as determined from the aerial survey data, provided tourists with significantly
better wildlife sightings (ground surveys) than the low tourism potential areas. Even Low
Paying tourism may not be economically viable in concessions that lack areas with intermediate
to high tourism potential. The largest part of the Northern Conservation Zone has low
tourism potential, but low tourism potential is not equal to low conservation value. Alternative
conservation strategies should be developed to complement the economic incentive
provided by wildlife-based tourism in Botswana.S1 File. Data_hplvtourismareas_northern_Botswana.xlsx.http://www.plosone.orgam201
The Vehicle, Spring 1996
Vol. 37, No. 2
Table of Contents
Poetry
AnyoneKeith Owenspage 2
Of Words and WidgetsJ. Dylan McNeillpage 3
HouseplantsPeter W. Katespage 4
IcarusJeff Vande Zandepage 5
UntitledPatrick F. Kellypage 7
CommuteWhitty Whitesellpage 8
During Graduate SchoolJeff Vande Zandepage 9
NeuteredJason S. Loguepage 10
Bitter WritingJ. Dylan McNeillpage 11
Song to Unknown SoldiersM. Olatoye Bayieupage 12
SoftAmy Haynespage 13
Mother\u27s Crossword PuzzlesMatthew J. Nelsonpage 14
Prose
Cold ShowerMatt Parkspage 17
Your Title HereKeith Owenspage 20
Biographies
Authorspage 27https://thekeep.eiu.edu/vehicle/1067/thumbnail.jp
Evaluation of an Intervention Providing HPV Vaccine in Schools
To conduct outcome and process evaluations of school-located HPV vaccination clinics in partnership with a local health department
Targeting HSP90 for cancer therapy
Heat-shock proteins (HSPs) are molecular chaperones that regulate protein folding to ensure correct conformation and translocation and to avoid protein aggregation. Heat-shock proteins are increased in many solid tumours and haematological malignancies. Many oncogenic proteins responsible for the transformation of cells to cancerous forms are client proteins of HSP90. Targeting HSP90 with chemical inhibitors would degrade these oncogenic proteins, and thus serve as useful anticancer agents. This review provides an overview of the HSP chaperone machinery and the structure and function of HSP90. We also highlight the key oncogenic proteins that are regulated by HSP90 and describe how inhibition of HSP90 could alter the activity of multiple signalling proteins, receptors and transcriptional factors implicated in carcinogenesis
First results from the JWST Early Release Science Program Q3D: Benchmark Comparison of Optical and Mid-IR Tracers of a Dusty, Ionized Red Quasar Wind at z=0.435
The [OIII] 5007 A emission line is the most common tracer of warm, ionized
outflows in active galactic nuclei across cosmic time. JWST newly allows us to
use mid-infrared spectral features at both high spatial and spectral resolution
to probe these same winds. Here we present a comparison of ground-based,
seeing-limited [OIII] and space-based, diffraction-limited [SIV] 10.51 micron
maps of the powerful, kpc-scale outflow in the Type 1 red quasar SDSS
J110648.32+480712.3. The JWST data are from the Mid-InfraRed Instrument (MIRI).
There is a close match in resolution between the datasets (0."4--0."6), in
ionization potential of the O+2 and S+3 ions (35 eV), and in line sensitivity
(1e-17 to 2e-17 erg/s/cm2/arcsec2). The [OIII] and [SIV] line shapes match in
velocity and linewidth over much of the 20 kpc outflowing nebula, and [SIV] is
the brightest line in the rest-frame 3.5--19.5 micron range, demonstrating its
usefulness as a mid-IR probe of quasar outflows. [OIII] is nevertheless
intriniscally brighter and provides better contrast with the point-source
continuum, which is strong in the mid-IR. There is a strong anticorrelation of
[OIII]/[SIV] with average velocity, which is consistent with a scenario of
differential obscuration between the approaching (blueshifted) and receding
(redshifted) sides of the flow. The dust in the wind may also obscure the
central quasar, consistent with models that attribute red quasar extinction to
dusty winds.Comment: Submitted to ApJ
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