10 research outputs found
Multiaxial high-cycle fatigue criteria and life prediction : Application to gas turbine blade
International audienceA recent work conducted by the authors (Maktouf and SaĂŻ, 2015) demonstrated that the root cause of the premature blade failure was caused by high-cycle fatigue (HCF) mechanism initiated at a localized carbon-rich area inducing grain boundary brittleness. The blade was subject to multiaxial cyclic loadings during its service life and any attempt to assess component fatigue strength leads to the question of choosing an appropriate fatigue design criterion. In this paper several multiaxial fatigue models are applied as post-processing step of the Finite Element Analysis (FEA) output results and the estimated fatigue lifetimes were assessed under different loading conditions. The material fatigue parameters, required as an input to the selected fatigue models were determined through a series of bending and torsion tests on specimens made of aged Inconel 718. A numerical post-processing algorithm was developed for Fatemi-Socie fatigue criterion and included as additional post-computation model in the used computer aided fatigue damage evaluation tool. The authors point out that the majority of the multiaxial fatigue studies available in the literature are conducted mainly for correlating the experimental laboratory results on specimens while they have been used in the frame of this study to investigate their application to an industrial case
Autoimmune atrophic gastritis-pathogenesis, pathology and management.
Autoimmune gastritis is a chronic progressive inflammatory condition that results in the replacement of the parietal cell mass by atrophic and metaplastic mucosa. A complex interaction of autoantibodies against the parietal cell proton pump and sensitized T cells progressively destroy the parietal cells, inducing hypochlorhydria and then achlorhydria, while autoantibodies against the intrinsic factor impair the absorption of vitamin B12. The resulting cobalamin deficiency manifests with megaloblastic anaemia and neurological and systemic signs and symptoms collectively known as pernicious anaemia. Previously believed to be predominantly a disease of elderly women of Northern European ancestry, autoimmune gastritis has now been recognized in all populations and ethnic groups, but because of the complexity of the diagnosis no reliable prevalence data are available. For similar reasons, as well as the frequent and often unknown overlap with Helicobacter pylori infection, the risk of gastric cancer has not been adequately assessed in these patients. This Review summarizes the epidemiology, pathogenesis and pathological aspects of autoimmune metaplastic atrophic gastritis. We also provide practical advice for the diagnosis and management of patients with this disease