The Fundamental Properties of Dwarf Elliptical Galaxies in Clusters

We present preliminary results of an extensive study of the fundamental properties of dwarf elliptical galaxies (dEs) in the Coma cluster. Our study will combine HST surface photometry with ground-based UBRIJK photometry and optical spectroscopy. The combined data set will be used to investigate the intrinsic correlations among global parameters in cluster dEs, including the Fundamental Plane, the color-magnitude relation, the Faber-Jackson and Kormendy relation, and velocity dispersion versus line strength indices. These empirical correlations have provided important constraints to theoretical models of galaxy formation and evolution for "normal" elliptical galaxies. Although dEs are the most abundant galaxy population in clusters their properties remain, however, largely unknown. Our study aims to provide an essential reference for testing current theories on the formation and evolution of dEs in clusters, and understanding their relation to more massive elliptical galaxies.Comment: 10 pages. To appear in "Star Formation through Time", 2003, ASP Conf. Ser. ed. Perez, Gonzalez Delgado, Tenorio-Tagl

Comparative Behavior of Built-up Cold-formed Box Sections under Rigid and Flexible End Support Conditions

According to section D1.2 of AISI S100-2007 for compression members composed of two sections in contact whose buckling mode involves shear forces in the connectors, a reduction must be made, KL r ⁄ must be replaced by ሺ KL r ⁄ሻ ୫ . This new modified slenderness ratio takes into account the connection weld spacing and the minimum radius of gyration of an individual shape in the built-up member. Under the provisions of section D1.2 a reduction in load capacity must be made for built-up welded box members, which are the subject of this study. An experimental investigation on 48 samples was done addressed to determine the comparative behavior under compression load of box sections composed of two C-section members in contact by seam welds with different weld spacings. The weld spacings in connections in the samples are 100 mm, 300 mm, 600 mm and 900 mm. The first set of 24 studs was tested under a rigid end support condition and the second set of 24 studs was tested using a flexible end support. The length of the samples was 900 mm with a cross-section of 100 mm x 100 mm. This configuration to form box members is widely used for columns or beams as frame and truss members. The base material thickness was 1.5 mm (gauge 16) for 24 samples and 2.0 mm (gauge 14) for the rest. The weld seams were 50 mm long in all cases except on the member ends; where they were 25 mm long. The testing done on the samples did not show a statistical reduction in the ultimate compression load capacity for these members except with a weld spacing of 900 mm and a flexible end support condition. The results of the investigation showed the reduction considered in section D1.2 section of AISI S100-2007 not applicable to determine the ultimate load cpacity for the rest of the member

Molecular Requirements for Ethanol Differential Allosteric Modulation of Ligand-Gated Ion Channels Based on Selective G Beta Gamma Modulation

It is now believed that the allosteric modulation produced by ethanol in glycine receptors (GlyRs) depends on alcohol binding to discrete sites within the protein structure. Thus, the differential ethanol sensitivity of diverse GlyR isoforms and mutants was explained by the presence of specific residues in putative alcohol pockets. Here, we demonstrate that ethanol sensitivity in two LGIC members, the GlyR adult alpha1 and embryonic alpha2 subunits, can be modified through selective mutations that rescued or impaired Gbetagamma modulation. Even though that both isoforms were able to physically interact with Gbetagamma, only the alpha1 GlyR was functionally modulated by Gbetagamma and pharmacological ethanol concentrations. Remarkably, the simultaneous switching of two transmembrane and a single extracellular residue in alpha2 GlyRs was enough to generate GlyRs modulated by Gbetagamma and low ethanol concentrations. Interestingly, while we found that these TM residues were different to those in the alcohol binding site, the extracellular residue was recently implicated in conformational changes important to generate a pre-open activated state that precedes ion channel gating. Thus, these results support the idea that the differential ethanol sensitivity of these two GlyR isoforms rests on conformational changes in transmembrane and extracellular residues within the ion channel structure rather than in differences in alcohol binding pockets. Our results describe the molecular basis for the differential ethanol sensitivity of two LGIC members based on selective Gbetagamma modulation and provide a new mechanistic framework for allosteric modulations of abuse drugs

Inferring the parallax of Westerlund 1 from Gaia DR2

Westerlund 1 (Wd1) is potentially the largest star cluster in the Galaxy. That designation critically depends upon the distance to the cluster, yet the cluster is highly obscured, making luminosity-based distance estimates difficult. Using {\it Gaia} Data Release 2 (DR2) parallaxes and Bayesian inference, we infer a parallax of $0.35^{+0.07}_{-0.06}$ mas corresponding to a distance of $2.6^{+0.6}_{-0.4}$ kpc. To leverage the combined statistics of all stars in the direction of Wd1, we derive the Bayesian model for a cluster of stars hidden among Galactic field stars; this model includes the parallax zero-point. Previous estimates for the distance to Wd1 ranged from 1.0 to 5.5 kpc, although values around 5 kpc have usually been adopted. The {\it Gaia} DR2 parallaxes reduce the uncertainty from a factor of 3 to 18\% and rules out the most often quoted value of 5 kpc with 99\% confidence. This new distance allows for more accurate mass and age determinations for the stars in Wd1. For example, the previously inferred initial mass at the main-sequence turn-off was around 40 M$_{\odot}$; the new {\it Gaia} DR2 distance shifts this down to about 22 M$_{\odot}$. This has important implications for our understanding of the late stages of stellar evolution, including the initial mass of the magnetar and the LBV in Wd1. Similarly, the new distance suggests that the total cluster mass is about four times lower than previously calculated.Comment: 14 pages, 10 figure

High-Resolution Magnetometry with a Spinor Bose-Einstein Condensate

We demonstrate a precision magnetic microscope based on direct imaging of the Larmor precession of a $^{87}$Rb spinor Bose-Einstein condensate. This magnetometer attains a field sensitivity of 8.3 pT/Hz$^{1/2}$ over a measurement area of 120 $\mu$m$^2$, an improvement over the low-frequency field sensitivity of modern SQUID magnetometers. The corresponding atom shot-noise limited sensitivity is estimated to be 0.15 pT/Hz$^{1/2}$ for unity duty cycle measurement. The achieved phase sensitivity is close to the atom shot-noise limit suggesting possibilities of spatially resolved spin-squeezed magnetometry. This magnetometer marks a significant application of degenerate atomic gases to metrology