On the Non-Gaussianity Observed in the COBE-DMR Sky Maps

In this paper we pursue the origin of the non-Gaussianity determined by a bispectrum analysis of the COBE-DMR 4-year sky maps. The robustness of the statistic is demonstrated by the rebinning of the data into 12 coordinate systems. By computing the bispectrum statistic as a function of various data partitions - by channel, frequency, and time interval, we show that the observed non-Gaussian signal is driven by the 53 GHz data. This frequency dependence strongly rejects the hypothesis that the signal is cosmological in origin. A jack-knife analysis of the coadded 53 and 90 GHz sky maps reveals those sky pixels to which the bispectrum statistic is particularly sensitive. We find that by removing data from the 53 GHz sky maps for periods of time during which a known systematic effect perturbs the 31 GHz channels, the amplitudes of the bispectrum coefficients become completely consistent with that expected for a Gaussian sky. We conclude that the non-Gaussian signal detected by the normalised bispectrum statistic in the publicly available DMR sky maps is due to a systematic artifact. The impact of removing the affected data on estimates of the normalisation of simple models of cosmological anisotropy is negligible.Comment: 14 pages, plus 8 Postscript and 3 GIF figures. LaTeX2e document using AASTeX v5.0 macros. Revised version accepted for publication in the Astrophysical Journal: small changes to the text, minor modifications to figures 1 and

The angular power spectrum of radio emission at 2.3 GHz

We have analysed the Rhodes/HartRAO survey at 2326 MHz and derived the global angular power spectrum of Galactic continuum emission. In order to measure the angular power spectrum of the diffuse component, point sources were removed from the map by median filtering. A least-square fit to the angular power spectrum of the entire survey with a power law spectrum C_l proportional to l^{-alpha}, gives alpha = 2.43 +/- 0.01 for l = 2-100. The angular power spectrum of radio emission appears to steepen at high Galactic latitudes and for observed regions with |b| > 20 deg, the fitted spectral index is alpha = 2.92 +/- 0.07. We have extrapolated this result to 30 GHz (the lowest frequency channel of Planck) and estimate that no significant contribution to the sky temperature fluctuation is likely to come from synchrotron at degree-angular scalesComment: 10 pages, 10 figures, accepted for publication by Astronomy & Astrophysic

Analysis of CMB foregrounds using a database for Planck

Within the scope of the Planck IDIS (Integrated Data Information System) project we have started to develop the data model for time-ordered data and full-sky maps. The data model is part of the Data Management Component (DMC), a software system designed according to a three-tier architecture which allows complete separation between data storage and processing. The DMC is already being used for simulation activities and the modeling of some foreground components. We have ingested several Galactic surveys into the database and used the science data-access interface to process the data. The data structure for full-sky maps utilises the HEALPix tessellation of the sphere. We have been able to obtain consistent measures of the angular power spectrum of the Galactic radio continuum emission between 408 MHz and 2417 MHz.Comment: 7 pages, 6 figures. To appear in the Proceedings of the MPA/ESO/MPE Joint Astronomy Conference "Mining The Sky

CCNE1 Amplification as a Predictive Biomarker of Chemotherapy Resistance in Epithelial Ovarian Cancer

Ovarian cancer is the most-deadly gynecologic malignancy, with greater than 14,000 women expected to succumb to the disease this year in the United States alone. In the front-line setting, patients are treated with a platinum and taxane doublet. Although 40-60% of patients achieve complete clinical response to first-line chemotherapy, 25% are inherently platinum-resistant or refractory with a median overall survival of about one year. More than 80% of women afflicted with ovarian cancer will recur. Many attempts have been made to understand the mechanism of platinum and taxane based chemotherapy resistance. However, despite decades of research, few predictive markers of chemotherapy resistance have been identified. Here, we review the current understanding of one of the most common genetic alterations in epithelial ovarian cancer, CCNE1 (cyclin E1) amplification, and its role as a potential predictive marker of cytotoxic chemotherapy resistance. CCNE1 amplification has been identified as a primary oncogenic driver in a subset of high grade serous ovarian cancer that have an unmet clinical need. Understanding the interplay between cyclin E1 amplification and other common ovarian cancer genetic alterations provides the basis for chemotherapeutic resistance in CCNE1 amplified disease. Exploration of the effect of cyclin E1 amplification on the cellular machinery that causes dysregulated proliferation in cancer cells has allowed investigators to explore promising targeted therapies that provide the basis for emerging clinical trials

LISA data analysis I: Doppler demodulation

The orbital motion of the Laser Interferometer Space Antenna (LISA) produces amplitude, phase and frequency modulation of a gravitational wave signal. The modulations have the effect of spreading a monochromatic gravitational wave signal across a range of frequencies. The modulations encode useful information about the source location and orientation, but they also have the deleterious affect of spreading a signal across a wide bandwidth, thereby reducing the strength of the signal relative to the instrument noise. We describe a simple method for removing the dominant, Doppler, component of the signal modulation. The demodulation reassembles the power from a monochromatic source into a narrow spike, and provides a quick way to determine the sky locations and frequencies of the brightest gravitational wave sources.Comment: 5 pages, 7 figures. References and new comments adde

Diffraction microtomography with sample rotation: influence of a missing apple core in the recorded frequency space

Diffraction microtomography in coherent light is foreseen as a promising technique to image transparent living samples in three dimensions without staining. Contrary to conventional microscopy with incoherent light, which gives morphological information only, diffraction microtomography makes it possible to obtain the complex optical refractive index of the observed sample by mapping a three-dimensional support in the spatial frequency domain. The technique can be implemented in two configurations, namely, by varying the sample illumination with a fixed sample or by rotating the sample using a fixed illumination. In the literature, only the former method was described in detail. In this report, we precisely derive the three-dimensional frequency support that can be mapped by the sample rotation configuration. We found that, within the first-order Born approximation, the volume of the frequency domain that can be mapped exhibits a missing part, the shape of which resembles that of an apple core. The projection of the diffracted waves in the frequency space onto the set of sphere caps covered by the sample rotation does not allow for a complete mapping of the frequency along the axis of rotation due to the finite radius of the sphere caps. We present simulations of the effects of this missing information on the reconstruction of ideal objects.Comment: 7 pages, 11 figures, presented at Focus On Microscopy 200

The shape of the CMB lensing bispectrum

Lensing of the CMB generates a significant bispectrum, which should be detected by the Planck satellite at the 5-sigma level and is potentially a non-negligible source of bias for f_NL estimators of local non-Gaussianity. We extend current understanding of the lensing bispectrum in several directions: (1) we perform a non-perturbative calculation of the lensing bispectrum which is ~10% more accurate than previous, first-order calculations; (2) we demonstrate how to incorporate the signal variance of the lensing bispectrum into estimates of its amplitude, providing a good analytical explanation for previous Monte-Carlo results; and (3) we discover the existence of a significant lensing bispectrum in polarization, due to a previously-unnoticed correlation between the lensing potential and E-polarization as large as 30% at low multipoles. We use this improved understanding of the lensing bispectra to re-evaluate Fisher-matrix predictions, both for Planck and cosmic variance limited data. We confirm that the non-negligible lensing-induced bias for estimation of local non-Gaussianity should be robustly treatable, and will only inflate f_NL error bars by a few percent over predictions where lensing effects are completely ignored (but note that lensing must still be accounted for to obtain unbiased constraints). We also show that the detection significance for the lensing bispectrum itself is ultimately limited to 9 sigma by cosmic variance. The tools that we develop for non-perturbative calculation of the lensing bispectrum are directly relevant to other calculations, and we give an explicit construction of a simple non-perturbative quadratic estimator for the lensing potential and relate its cross-correlation power spectrum to the bispectrum. Our numerical codes are publicly available as part of CAMB and LensPix.Comment: 32 pages, 10 figures; minor changes to match JCAP-accepted version. CMB lensing and primordial local bispectrum codes available as part of CAMB (http://camb.info/