AATF/Che-1-An RNA Binding Protein at the Nexus of DNA Damage Response and Ribosome Biogenesis

The DNA damage response (DDR) is a complex signaling network that is activated upon genotoxic stress. It determines cellular fate by either activating cell cycle arrest or initiating apoptosis and thereby ensures genomic stability. The Apoptosis Antagonizing Transcription Factor (AATF/Che-1), an RNA polymerase II-interacting transcription factor and known downstream target of major DDR kinases, affects DDR signaling by inhibiting p53-mediated transcription of pro-apoptotic genes and promoting cell cycle arrest through various pathways instead. Specifically, AATF was shown to inhibit p53 expression at the transcriptional level and repress its pro-apoptotic activity by direct binding to p53 protein and transactivation of anti-apoptotic genes. Solid and hematological tumors of various organs exploit this function by overexpressing AATF. Both copy number gains and high expression levels of AATF were associated with worse prognosis or relapse of malignant tumors. Recently, a number of studies have enabled insights into the molecular mechanisms by which AATF affects both DDR and proliferation. AATF was found to directly localize to sites of DNA damage upon laser ablation and interact with DNA repair proteins. In addition, depletion of AATF resulted in increased DNA damage and decrease of both proliferative activity and genotoxic tolerance. Interestingly, considering the role of ribosomal stress in the regulation of p53, more recent work established AATF as ribosomal RNA binding protein and enabled insights into its role as an important factor for rRNA processing and ribosome biogenesis. This Mini Review summarizes recent findings on AATF and its important role in the DDR, malignancy, and ribosome biogenesis

Crystalline Order on a Sphere and the Generalized Thomson Problem

We attack generalized Thomson problems with a continuum formalism which exploits a universal long range interaction between defects depending on the Young modulus of the underlying lattice. Our predictions for the ground state energy agree with simulations of long range power law interactions of the form 1/r^{gamma} (0 < gamma < 2) to four significant digits. The regime of grain boundaries is studied in the context of tilted crystalline order and the generality of our approach is illustrated with new results for square tilings on the sphere.Comment: 4 pages, 5 eps figures Fig. 2 revised, improved Fig. 3, reference typo fixe

Radiation in Lorentz violating electrodynamics

Synchrotron radiation is analyzed in the classical effective Lorentz invariance violating model of Myers-Pospelov. Within the full far-field approximation we compute the electric and magnetic fields, the angular distribution of the power spectrum and the total emitted power in the m-th harmonic, as well as the polarization. We find the appearance of rather unexpected and large amplifying factors, which go together with the otherwise negligible naive expansion parameter. This opens up the possibility of further exploring Lorentz invariance violations by synchrotron radiation measurements in astrophysical sources where these amplifying factors are important.Comment: Presented at the Second Mexican Meeting on Theoretical and Experimental Physics, El Colegio Nacional, Mexico City, 6-10 September 200

Limits on models of the ultrahigh energy cosmic rays based on topological defects

An erratum exists for this article. Please see the description link below for details.Using the propagation of ultrahigh energy nucleons, photons, and electrons in the universal radiation backgrounds, we obtain limits on the luminosity of topological defect scenarios for the origin of the highest energy cosmic rays. The limits are set as a function of the mass of the X particles emitted by the cosmic strings or other defects, the cosmological evolution of the topological defects, and the strength of the extragalactic magnetic fields. The existing data on the cosmic ray spectrum and on the isotropic 100 MeV gamma-ray background limit significantly the parameter space in which topological defects can generate the flux of the highest energy cosmic rays, and rule out models with the standard X-particle mass of 10¹⁶GeV and higher.R. J. Protheroe and Todor Stane

Asymptotic conditions of motion for radiating charged particles

Approximate asymptotic conditions on the motion of compact, electrically charged particles are derived within the framework of general relativity using the Einstein- Infeld-Hoffmann (EIH) surface integral method. While superficially similar to the Abraham-Lorentz and Lorentz-Dirac (ALD) equations of motion, these conditions differ from them in several fundamental ways. They are not equations of motion in the usual sense but rather a set of conditions which these motions must obey in the asymptotic future of an initial value surface. In addition to being asymptotic, these conditions of motion are approximate and apply, as do the original EIH equations, only to slowly moving systems. Also, they do not admit the run- away solutions of these other equations. As in the original EIH work, they are integrability conditions gotten from integrating the empty-space (i.e., source free) Einstein-Maxwell equations of general relativity over closed two-surfaces surrounding the sources of the fields governed by these equations. No additional ad hoc assumptions, such as the form of a force law or the introduction of inertial reaction terms, needed to derive the ALD equations are required for this purpose. Nor is there a need for any of the infinite mass renormalizations that are required in deriving these other equations.Comment: 15 page