136 research outputs found
Construction and Measurements of an Improved Vacuum-Swing-Adsorption Radon-Mitigation System
In order to reduce backgrounds from radon-daughter plate-out onto detector
surfaces, an ultra-low-radon cleanroom is being commissioned at the South
Dakota School of Mines and Technology. An improved vacuum-swing-adsorption
radon mitigation system and cleanroom build upon a previous design implemented
at Syracuse University that achieved radon levels of
0.2Bqm. This improved system will employ a better pump and
larger carbon beds feeding a redesigned cleanroom with an internal HVAC unit
and aged water for humidification. With the rebuilt (original) radon mitigation
system, the new low-radon cleanroom has already achieved a 300
reduction from an input activity of Bqm to a
cleanroom activity of Bqm.Comment: 5 pages, 4 figures, Proceedings of Low Radioactivity Techniques (LRT)
2015, Seattle, WA, March 18-20, 201
Sex steroids do not affect shigatoxin cytotoxicity on human renal tubular or glomerular cells
BACKGROUND: The greater susceptibility of children to renal injury in post-diarrheal hemolytic-uremic syndrome (HUS) may be related, at least in part, to heightened renal cell sensitivity to the cytotoxic effect of Shiga toxin (Stx), the putative mediator of kidney damage in HUS. We hypothesized that sexual maturation, which coincides with a falling incidence of HUS, may induce a relatively Stx-resistant state in the renal cells. METHODS: Cultured human glomerular endothelial (HGEN), human glomerular visceral epithelial (HGEC) and human proximal tubule (HPT) cells were exposed to Stx-1 after pre-incubation with progesterone, β-estradiol or testosterone followed by determination of cytotoxicity. RESULTS: Under basal conditions, Stx-1 potently and dose-dependently killed HPT and HGEC, but had relatively little effect on HGEN. Pre-incubation for 1, 2 or 7 days with physiologic or pharmacologic concentrations of progesterone, β-estradiol or testosterone had no effect on Stx-1 cytotoxicity dose-response on any cell type. In addition, no steroid altered Gb3 expression (Stx receptor) by any cell type at any time point. CONCLUSION: These data do not support the notion that hormonal changes associated with puberty induce an Stx-resistant state within kidney cells
Contamination Control and Assay Results for the Majorana Demonstrator Ultra Clean Components
The MAJORANA DEMONSTRATOR is a neutrinoless double beta decay experiment
utilizing enriched Ge-76 detectors in 2 separate modules inside of a common
solid shield at the Sanford Underground Research Facility. The DEMONSTRATOR has
utilized world leading assay sensitivities to develop clean materials and
processes for producing ultra-pure copper and plastic components. This
experiment is now operating, and initial data provide new insights into the
success of cleaning and processing. Post production copper assays after the
completion of Module 1 showed an increase in U and Th contamination in finished
parts compared to starting bulk material. A revised cleaning method and
additional round of surface contamination studies prior to Module 2
construction have provided evidence that more rigorous process control can
reduce surface contamination. This article describes the assay results and
discuss further studies to take advantage of assay capabilities for the purpose
of maintaining ultra clean fabrication and process design.Comment: Proceedings of Low Radioactivity Techniques (LRT May 2017, Seoul
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