The Distance of the SNR Kes 75 and PWN PSR J1846-0258 System

The supernova remnant (SNR) Kes 75/PSR J1846-0258 association can be regarded as certain due to the accurate location of young PSR J1846-0258 at the center of Kes 75 and the detected bright radio/X-ray synchrotron nebula surrounding the pulsar. We provide a new distance estimate to the SNR/pulsar system by analyzing the HI and $^{13}$CO maps, the HI emission and absorption spectra, and the $^{13}$CO emission spectrum of Kes 75. No absorption features at negative velocities strongly argue against the widely-used large distance of 19 to 21 kpc for Kes 75, and show that Kes 75 is within the Solar circle, i.e. a distance $d<$13.2 kpc. Kes 75 is likely at distance of 5.1 to 7.5 kpc because the highest HI absorption velocity is at 95 km/s and no absorption is associated with a nearby HI emission peak at 102 km/s in the direction of Kes 75. This distance to Kes 75 gives a reasonable luminosity of PSR J1846-0258 and its PWN, and also leads to a much smaller radius for Kes 75. So the age of the SNR is consistent with the spin-down age of PSR J1846-0258, confirming this pulsar as the second-youngest in the Galaxy.Comment: 5 pages, two pictures, A&A letter

The Euclid Archive Processing and Data Distribution Systems: A Distributed Infrastructure for Euclid and Associated Data

The Euclid Archive System is an ambitious information system, which sits at the heart of the Euclid Science Ground Segment. It is a joint development between the Euclid Consortium and the ESAC Science Data Centre. It encompases both Euclid data and the large volume of associated ground based data (e.g. KiDS, DES and LSST). The Euclid Science Ground Segment consists of the Euclid Science Operations Centre and ten national Science Data Centres. The large data volumes demand that data transfer is minimized and that the processing is taken to the data. This is supported by the Euclid Archive Data Processing System and the Euclid Archive Distributed Data System. The Data Processing System consists of a central metadata repository, which contains the information necessary to process any data item and full data lineage of any data product created. The Distributed Data System provides a cloud solution with a node at each of the national Science Data Centres, which controls data storage and transfer. It supports a large number of storage types, including POSIX, iRODS, gridftp and Xrootd. No limitations are placed on the storage implemented at an individual SDC. Further more, the user of the system needs no knowledge of where data is located. Jobs will be started at the most appropriate locations, or data transferred as necessary

The Role of the Euclid Archive System in the Processing of Euclid and External Data

Euclid is an ESA M2 mission which will create a 15,000 square degrees space-based survey: the Euclid Archive System (EAS) is a core element of the Science Ground Segment (SGS) of Euclid. The EAS follows a data-centric approach to data processing, whereby the Data Processing System (DPS) is responsible for the centralized metadata storage and the Distributed Storage System (DSS) supports the distributed storage of data files. The EAS-DPS implements the Euclid Common Data model and along with the EAS-DSS provides numerous services for Euclid Consortium users and SGS subsystems. In addition, the EAS-DPS assists in the preparation of Euclid data releases which are copied to the third EAS subsystem, the ESA developed Science Archive System (SAS) where they become available to the wider astronomical community. The EAS-DPS implements the object-oriented Euclid Common Data Model using a relational DBMS for the storage. The EAS-DPS supports the tracing of the lineage of any data item in the system, provides services for the data quality assessment and the data processing orchestration. The EAS-DSS is a distributed storage system which is based on a set of storage nodes located in each of the ten Science Data Centers of the Euclid SGS. The storage nodes supports a wide range of solutions from local disk, using a unix filesystem, to iRODS nodes or Grid storage elements. In this paper the architectural design of EAS-DPS and EAS-DSS are reviewed: the interaction between them and tests of the already implemented components are described

The Euclid Archive Processing and Data Distribution Systems: A Distributed Infrastructure for Euclid and Associated Data

The Euclid Archive System is an ambitious information system, which sits at the heart of the Euclid Science Ground Segment. It is a joint development between the Euclid Consortium and the ESAC Science Data Centre. It encompases both Euclid data and the large volume of associated ground based data (e.g. KiDS, DES and LSST). The Euclid Science Ground Segment consists of the Euclid Science Operations Centre and ten national Science Data Centres. The large data volumes demand that data transfer is minimized and that the processing is taken to the data. This is supported by the Euclid Archive Data Processing System and the Euclid Archive Distributed Data System. The Data Processing System consists of a central metadata repository, which contains the information necessary to process any data item and full data lineage of any data product created. The Distributed Data System provides a cloud solution with a node at each of the national Science Data Centres, which controls data storage and transfer. It supports a large number of storage types, including POSIX, iRODS, gridftp and Xrootd. No limitations are placed on the storage implemented at an individual SDC. Further more, the user of the system needs no knowledge of where data is located. Jobs will be started at the most appropriate locations, or data transferred as necessary

The Euclid Archive Processing and Data Distribution Systems: A Distributed Infrastructure for Euclid and Associated Data

The Euclid Archive System is an ambitious information system, which sits at the heart of the Euclid Science Ground Segment. It is a joint development between the Euclid Consortium and the ESAC Science Data Centre. It encompases both Euclid data and the large volume of associated ground based data (e.g. KiDS, DES and LSST). The Euclid Science Ground Segment consists of the Euclid Science Operations Centre and ten national Science Data Centres. The large data volumes demand that data transfer is minimized and that the processing is taken to the data. This is supported by the Euclid Archive Data Processing System and the Euclid Archive Distributed Data System. The Data Processing System consists of a central metadata repository, which contains the information necessary to process any data item and full data lineage of any data product created. The Distributed Data System provides a cloud solution with a node at each of the national Science Data Centres, which controls data storage and transfer. It supports a large number of storage types, including POSIX, iRODS, gridftp and Xrootd. No limitations are placed on the storage implemented at an individual SDC. Further more, the user of the system needs no knowledge of where data is located. Jobs will be started at the most appropriate locations, or data transferred as necessary

The Euclid Archive Processing and Data Distribution Systems: A Distributed Infrastructure for Euclid and Associated Data

The Euclid Archive System is an ambitious information system, which sits at the heart of the Euclid Science Ground Segment. It is a joint development between the Euclid Consortium and the ESAC Science Data Centre. It encompases both Euclid data and the large volume of associated ground based data (e.g. KiDS, DES and LSST). The Euclid Science Ground Segment consists of the Euclid Science Operations Centre and ten national Science Data Centres. The large data volumes demand that data transfer is minimized and that the processing is taken to the data. This is supported by the Euclid Archive Data Processing System and the Euclid Archive Distributed Data System. The Data Processing System consists of a central metadata repository, which contains the information necessary to process any data item and full data lineage of any data product created. The Distributed Data System provides a cloud solution with a node at each of the national Science Data Centres, which controls data storage and transfer. It supports a large number of storage types, including POSIX, iRODS, gridftp and Xrootd. No limitations are placed on the storage implemented at an individual SDC. Further more, the user of the system needs no knowledge of where data is located. Jobs will be started at the most appropriate locations, or data transferred as necessary

Age-related changes in Drosophila midgut are associated with PVF2, a PDGF/VEGF-like growth factor

Age-associated changes in stem cell populations have been implicated in age-related diseases, including cancer. However, little is known about the underlying molecular mechanisms that link aging to the modulation of adult stem cell populations. Drosophila midgut is an excellent model system for the study of stem cell renewal and aging. Here we describe an age-related increase in the number and activity of intestinal stem cells (ISCs) and progenitor cells in Drosophila midgut. We determined that oxidative stress, induced by paraquat treatment or loss of catalase function, mimicked the changes associated with aging in the midgut. Furthermore, we discovered an age-related increase in the expression of PVF2, a Drosophila homologue of human PDGF/VEGF, which was associated with and required for the age-related changes in midgut ISCs and progenitor cell populations. Taken together, our findings suggest that PDGF/VEGF may play a central role in age-related changes in ISCs and progenitor cell populations, which may contribute to aging and the development of cancer stem cells