16 research outputs found
IL-25 Induces M2 Macrophages and Reduces Renal Injury in Proteinuric Kidney Disease
The kidney contains receptors for the cytokine IL-25, but the effects of IL-25 in CKD are unknown. Here, we induced adriamycin nephropathy in both BALB/c mice and severe combined immunodeficient (SCID) mice, and we injected IL-25 for 7 consecutive days starting at day 5 after adriamycin administration. BALB/c mice treated with IL-25 had less glomerulosclerosis, tubular atrophy, interstitial expansion, and proteinuria than control mice at day 28. IL-25 increased the levels of IL-4 and IL-13 in serum, kidney, renal draining lymph nodes, and CD4+ lymphocytes. IL-25 also directly suppressed effector macrophages in vitro and in vivo and induced alternatively activated (M2) macrophages in vivo. However, in SCID mice and in BALB/c mice treated with IL-4/13–neutralizing antibody, IL-25 failed to protect against renal injury and did not induce M2. In conclusion, IL-25 protects against renal injury in adriamycin nephropathy in mice by, at least in part, inducing Th2 immune responses
Simultaneous Determination of the Contents of Three Stilbene Oligomers in Caragana sinica Collected in Different Seasons Using an Improved HPLC Method
Quantitative Determination of Stilbene Oligomers in Jin Que-gen Collected from Different Regions by a HPLC Method
A Tiger Without Teeth? Regulation of Administrative Monopoly Under China’s Anti-Monopoly Law
Beyond Guanxi: Network contingencies in Taiwanese business groups
10.1177/0170840605058230Organization Studies274461-48