Nindestructive Evaluation of Metal Matrix Composite Products with Implanted Defects

The Westinghouse Science and Technology Center has undertaken a program to develop nondestructive evaluation (NDE) techniques for characterizing the internal structure of SiC particle-reinforced aluminum matrix composites at critical stages during fabrication [1–5]. Because of the large number of processing variables in the manufacture of metal matrix composites (MMC), the likelihood of having detrimental discontinuities is high. The detection of potential defects early in the processing cycle would increase the overall system yield, lower costs, and enhance final product quality [4]. The aim of this investigation was to develop and conduct NDE at various stages of MMC fabrication, correlate the results with microstructural characterization, and establish qualified product quality assurance processes. A large-scale billet was fabricated specially using powder metallurgy techniques to facilitate this objective. The billet contained implanted silicon-carbide particle and aluminum powder clusters as inspection targets. The billet was subsequently extruded into a primary cylindrical extrusion, and finally into a flat plate. The NDE objectives included evaluating the detectability and mapping the implanted defects through each of the processing steps. Comprehensive evaluation of MMC structures requires the use of multiple NDE techniques, including ultrasonic, eddy current, and radiographic testing. This paper concentrates on the results of the ultrasonic investigations. Our experimental approach was: (1) fabricate a MMC billet with intentionally placed inhomogeneities; (2) develop and implement NDE techniques to characterize the MMC internal structure; (3) extend the NDE techniques to intermediate processing and final product forms; and (4) correlate the NDE data with microstructural characterization and mechanical testing results

Thirty Years After Michael E. Porter: What Do We Know About Business Exit?

Although a business exit is an important corporate change initiative, the buyer’s side seems to be more appealing to management researchers than the seller’s because acquisitions imply growth, i.e., success. Yet from an optimistic viewpoint, business exit can effectively create value for the selling company. In this paper we attempt to bring the relevance of the seller’s side back into our consciousness by asking: What do we know about business exit? We start our exploration with Porter (1976), focusing on literature that investigates the antecedents of, barriers to, and outcomes of business exit. We also include studies from related fields such as finance and economics.1 Through this research we determine three clusters of findings: factors promoting business exit, exit barriers, and exit outcomes. Overall, it is the intention of this paper to highlight the importance of business exit for research and practice. Knowing what we know about business exits and their high financial value we should bear in mind that exit need not mean failure but a new beginning for a corporation

A population-based analysis of germline BAP1 mutations in melanoma

Germline mutation of the BRCA1 associated protein-1 (BAP1) gene has been linked to uveal melanoma, mesothelioma, meningioma, renal cell carcinoma and basal cell carcinoma. Germline variants have also been found in familial cutaneous melanoma pedigrees, but their contribution to sporadic melanoma has not been fully assessed. We sequenced BAP1 in 1,977 melanoma cases and 754 controls and used deubiquitinase assays, a pedigree analysis, and a histopathological review to assess the consequences of the mutations found. Sequencing revealed 30 BAP1 variants in total, of which 27 were rare (ExAc allele frequency <0.002). Of the 27 rare variants, 22 were present in cases (18 missense, one splice acceptor, one frameshift and two near splice regions) and 5 in controls (all missense). A missense change (S98R) in a case that completely abolished BAP1 deubiquitinase activity was identified. Analysis of cancers in the pedigree of the proband carrying the S98R variant and in two other pedigrees carrying clear loss-of-function alleles showed the presence of BAP1-associated cancers such as renal cell carcinoma, mesothelioma and meningioma, but not uveal melanoma. Two of these three probands carrying BAP1 loss-of-function variants also had melanomas with histopathological features suggestive of a germline BAP1 mutation. The remaining cases with germline mutations, which were predominantly missense mutations, were associated with less typical pedigrees and tumours lacking a characteristic BAP1-associated histopathological appearances, but may still represent less penetrant variants. Germline BAP1 alleles defined as loss-of-function or predicted to be deleterious/damaging are rare in melanoma

Towards a global land surface climate fiducial reference measurements network

There is overwhelming evidence that the climate system has warmed since the instigation of instrumental meteorological observations. The Fifth Assessment Report of the Intergovernmental Panel on Climate Change concluded that the evidence for warming was unequivocal. However, owing to imperfect measurements and ubiquitous changes in measurement networks and techniques, there remain uncertainties in many of the details of these historical changes. These uncertainties do not call into question the trend or overall magnitude of the changes in the global climate system. Rather, they act to make the picture less clear than it could be, particularly at the local scale where many decisions regarding adaptation choices will be required, both now and in the future. A set of high-quality long-term fiducial reference measurements of essential climate variables will enable future generations to make rigorous assessments of future climate change and variability, providing society with the best possible information to support future decisions. Here we propose that by implementing and maintaining a suitably stable and metrologically well-characterized global land surface climate fiducial reference measurements network, the present-day scientific community can bequeath to future generations a better set of observations. This will aid future adaptation decisions and help us to monitor and quantify the effectiveness of internationally agreed mitigation steps. This article provides the background, rationale, metrological principles, and practical considerations regarding what would be involved in such a network, and outlines the benefits which may accrue. The challenge, of course, is how to convert such a vision to a long-term sustainable capability providing the necessary well-characterized measurement series to the benefit of global science and future generations

Framed Hilbert space: hanging the quasi-probability pictures of quantum theory

Building on earlier work, we further develop a formalism based on the mathematical theory of frames that defines a set of possible phase-space or quasi-probability representations of finite-dimensional quantum systems. We prove that an alternate approach to defining a set of quasi-probability representations, based on a more natural generalization of a classical representation, is equivalent to our earlier approach based on frames, and therefore is also subject to our no-go theorem for a non-negative representation. Furthermore, we clarify the relationship between the contextuality of quantum theory and the necessity of negativity in quasi-probability representations and discuss their relevance as criteria for non-classicality. We also provide a comprehensive overview of known quasi-probability representations and their expression within the frame formalism.Comment: 46 pages, 1 table, contains a review of finite dimensional quasi-probability function

Quasi-probability representations of quantum theory with applications to quantum information science

This article comprises a review of both the quasi-probability representations of infinite-dimensional quantum theory (including the Wigner function) and the more recently defined quasi-probability representations of finite-dimensional quantum theory. We focus on both the characteristics and applications of these representations with an emphasis toward quantum information theory. We discuss the recently proposed unification of the set of possible quasi-probability representations via frame theory and then discuss the practical relevance of negativity in such representations as a criteria for quantumness.Comment: v3: typos fixed, references adde