EVALUATION OF PRESCRIBING PATTERN OF FIXED DOSE COMBINATIONS OF ANTIHYPERTENSIVES AND ANTIDIABETIC AGENTS

  Objective: The objective of this research was to evaluate prescribing pattern of fixed dose combinations (FDCs) of antihypertensives and antidiabetic agents among patients of private hospitals.Methods: An observational study was carried out in the outpatient department of two hospitals. Data of patients being diagnosed with the symptoms of hypertension and diabetes were enrolled which mainly included information related to prescribe FDCs, i.e., antihypertensives and antidiabetics, respectively. Descriptive analysis of collected information was done which involved representation of demographical data, number of comorbidities, number of FDCs prescribed, and type of FDCs consequently.Results: Combination drug therapy was prescribed in maximum patients, which was enumerated as 93% among hypertensive patients and about 91% in diabetics. Average age of patients suffering more from hypertension was 64.5±18 years and that in case of diabetes sufferers was 54.5±18 years. The most frequent combination prescribed in hypertensive patients was of angiotensin receptor blocker (ARB) and calcium channel blocker (CCB) which were about 53%, and in diabetic patients, it was of biguanides and sulfonylureas about 63%. Comorbidity too was notified, and its estimation was 61% in hypertensive patients and 72% in diabetic patients, respectively.Conclusion: The study here demonstrates that the most often prescribed antihypertensive combination is of ARB and CCB, and subsequently for diabetes, the oral hypoglycemic combination is of biguanides and sulfonylureas. Most of FDCs contained medications of these two classes. Positive results were also observed in levels of blood pressure and glucose within the normal range

Fluorinated Epoxy Resins-based Sorbent Coating Materials for Quartz Piezoelectric Crystal Detector

Fluorinated epoxy resins were synthesised and evaluated as sorbent coating materials for the detection of organophosphorus compounds using quartz piezoelectric crystal detector. These resins were prepared by reacting excess of epichlorohydrin with each of or in combination of fluorinated diols, ie, a, a, a', a' tetrakis (trifluoromethyl) 1,3 benzene dimethanol (TTFMBD), 4,4'bis-2-hydroxy hexafluoro isopropyl) biphenyl (BHHFIBP), 4,4'dihydroxyocta fluorodiphenyl (DHOFDP) and 2,2,3,3,4,4 hexafluoro 1,5 pentanediol (HFPD) in the presence of sodium hydroxide at reflux temperature. These polymers were extracted in organic solvents and dried. Each of these fluoroepoxy resins were coated over quartz piezoelectric crystal by solution-casting method and tested using dimethylmethyl phosphonate (DMMP) as model compound. Change in the  frequency (AF) of quartz piezoelectric crystal oscillator was recorded. Sensitive and potential fluorinated epoxy resins, ie, diglycidylethers (DGE) of HFPD-TTFMBD (in the molar ratio 6:4) and DGE (HFPD-BHHFIBP in the molar ratio 4:6) were characterised by viscosity, number average molecular weight (Mn), epoxy equivalent, infrared spectroscopy, and thermal stability

An overview of the predictors of symptomatic urinary tract infection among nursing students

Background: Urinary tract infection (UTI) is the most common infection experienced by humans after respiratory and gastro‑intestinal infections, and also the most common cause of nosocomial infections for patients admitted to hospitals indeed UTIs are the most frequent bacterial infection in women. Aim: The aim was to determine the prevalence of UTI and to identify factors associated with an increased risk of UTI among nursing students. Subjects and Methods: The cross‑sectional study involved 177 unmarried nursing students aged 18–30 years studying in the SRMSIMS, Nursing College Bareilly. A structured questionnaire was used, and study subjects were asked regarding the symptoms of UTI in the previous 3 months. Chi‑square test and Univariate Logistic Regression was used to analyze the data. Results: The overall prevalence of UTI was found to be 19.8% (35/177). Rural background, inadequate water intake, and unsatisfactory toilet habits were found to be strong predictors of UTI. Conclusions: There is an urgent need to sensitize the nursing students regarding the growing need of the issue so that they themselves become aware in addition to raising the awareness of other high‑risk groups.Keywords: Nursing students, Prevalence, Urinary tract infectio

Polyethylene Maleate Copolyesters as Coating Materials for Piezoelectric Quartz Crystal-based Chemical Sensors

Polyethylene maleate (PEM) was synthesised by direct polycondensation of maleic anhydride and ethylene glycol in toluene under reflux usingp-toluene sulphonic acid as a catalyst. Structure of PEM was further modified by varying nature of diols and acid components, chain length of glycols, incorporation of aromatic and fluorine groups in the chain. Formation of PEM was monitored by gas chromatography. The parameters like degree of polymerisation, number average molecular weight (Mn), and weight average molecular weight (Mw) were calculated from the extent of reaction and stoichiometric ratio of the reactants. The number average molecular weight was also determined using Knauer vapour pressure osmometer. Cohesive energy, volume, and solubility parameters of PEM-based copolyesters were calculated by group contribution method. These PEM-based copolyesters’ have been evaluated as sorbent-coating materials for the detection of organ0 phosphorus(OP)compo using dimethylmethylphosphonate (DMMP) as model compound and piezoelectric crystal detector. PEMbisphenol A is found to be the most sensitive and potential coating material for the detection of OP compounds using piezoelectric crystal detector. Potential PEM-based copolyesters have been characterised by viscosity, infrared spectroscopy, NMR spectroscopy, Mn and thermal stability

A non-degenerate optical parametric oscillator as a high-flux source for quantum lithography

We investigate the use of a non-degenerate parametric oscillator (NDPO) as a source for quantum lithography, for which the light can have high-flux and strong non-classical features. This builds on the proposal of Boto, et al. [A. N. Boto, et al., PRL (85), 2733 (2000)], for etching simple patterns on multi-photon absorbing materials with sub-Rayleigh resolution, using special two-mode entangled states of light. An NDPO has two outgoing modes differentiated by polarization or direction of propagation, but sharing the same optical frequency. We derive analytical expressions for the multi-photon absorption rates when the NDPO is operated below, near, and above its threshold. The resulting interference patterns are characterized by an effective wavelength half that for the illuminating modes. We compare our results with those for the case of a high-gain optical amplifier source, and discuss the relative merit of the NDPO

Higher order antibunching is not a rare phenomenon

Since the introduction of higher order nonclassical effects, higher order squeezing has been reported in a number of different physical systems but higher order antibunching is predicted only in three particular cases. In the present work, we have shown that the higher order antibunching is not a rare phenomenon rather it can be seen in many simple optical processes. To establish our claim, we have shown it in six wave mixing process, four wave mixing process and in second harmonic generation process.Comment: 6 pages, no figure, Latex 2

Processing and evaluation of dissimilar Al-SS friction welding of pipe configuration : nondestructive inspection, properties, and microstructure

In the present investigation, dissimilar friction welding between AA6063-T6 and SS 304L materials of pipe joint configuration with an outer diameter of 88.90 mm and a wall thickness of 5.4 mm was performed. Four different experimental conditions were varied based on visual inspection after each weld. The welded pipe joints were evaluated by vacuum leak detection, thermal shock test, pneumatic pressure test, tensile test, optical and scanning electron microscopy, energy dispersive X-ray spectroscopy, X-ray diffractions, X-ray elemental mapping, and hardness measurements. The results revealed that friction welded Al-SS bimetallic pipes sustained ultra-high vacuum pressure and cryogenic working environments without leak detection. Al-SS friction welded pipe resulted in high tensile strength with 72% of joint efficiency as compared to AA6063-T6 base material. Microstructure variations were observed significant towards AA6063-T6 material close to the Al-SS interface. The intermetallic compound of Fe3Al phase was identified with a reaction layer between Al-SS joints with varying thickness of 1.1 µm to 2.0 µm

Microstructure evolution and mechanical properties of continuous drive friction welded dissimilar copper-stainless steel pipe joints

In the present investigation, the microstructure evolution and mechanical properties of dissimilar materials Copper-Stainless Steel pipe joints welded by continuous drive friction welding under two different processing conditions are analyzed. The processing conditions of friction welding for copper-stainless steel joints are varied by two friction times of 10 s and 15 s while keeping other processing parameters constant. The welded specimens are analyzed for materials characterizations and mechanical testing using optical microscopy and scanning electron microscopy, electron dispersive x-ray spectroscopy, electron backscatter diffraction analysis, X-ray diffractions, tensile testing, and microhardness measurements. The results revealed that the major microstructural evolution is observed at the Cu side with dynamic recrystallized zones. Enhanced metallurgical bonding between Cu-SS materials is obtained with microstructural evolutions (such as full dynamic recrystallized zone at Cu side and quenching zone at SS side) near to Cu-SS interface, in case of weld made by friction time of 15 s. Superior interatomic diffusion leading to enhanced metallurgical bonding is evidenced for weld made by friction time of 15 s. The reaction layer thickness influences the bonding and mechanical properties of Cu-SS friction welds. The reaction layer thickness of 17.28 μm is observed for the weld made by friction time of 10 s, whereas the reaction layer thickness of 1.21 μm is observed for the weld made by friction time of 15 s. The ultimate tensile strength of 181.05 MPa is obtained for Cu-SS friction weld

Friction welding of dissimilar joints copper-stainless steel pipe consist of 0.06 wall thickness to pipe diameter ratio

This paper examines dissimilar friction welding between electrolytic tough pitch copper (ETP-Cu) and stainless steel (SS) of grade 304 L for pipe joint configuration, having 0.06 wall thickness to pipe diameter ratio. The welding is performed using the continuous drive friction welding method. The welded joint is evaluated by visual inspection, leak-proof ability by helium leak detection testing, microstructure features by optical and scanning electron microscopy, energy dispersive x-ray spectroscope, x-ray diffraction patterns, tensile testing, and hardness measurements. The continuity of welding is evaluated by peripheral inspection and testing on four different locations of pipe welded joint. The results revealed that sound joints between dissimilar materials of Cu-SS are established with evidence of resistance to leak at room temperature and after cryogenic shock test. The Cu-SS pipe joint received excellent strength of 242.48 N/mm2, which is nearly 80% of ETP-Cu base material. The microstructure changes are distinctly observed at the Cu side, whereas no significant microstructure changes are observed at the SS side. The microstructure features are consisting of full dynamic recrystallization zone and partial dynamic recrystallization zone that are identified at the Cu side. However, no adverse effect of microstructure on tensile strength and hardness is observed. The weld continuity in the periphery of pipe configuration is observed at four different locations. A continuous reaction layer at four investigated locations is identified, with the presence of Cu and Fe elements at the joint interface