Rare and Common Variants Conferring Risk of Tooth Agenesis

We present association results from a large genome-wide association study of tooth agenesis (TA) as well as selective TA, including 1,944 subjects with congenitally missing teeth, excluding third molars, and 338,554 controls, all of European ancestry. We also tested the association of previously identified risk variants, for timing of tooth eruption and orofacial clefts, with TA. We report associations between TA and 9 novel risk variants. Five of these variants associate with selective TA, including a variant conferring risk of orofacial clefts. These results contribute to a deeper understanding of the genetic architecture of tooth development and disease. The few variants previously associated with TA were uncovered through candidate gene studies guided by mouse knockouts. Knowing the etiology and clinical features of TA is important for planning oral rehabilitation that often involves an interdisciplinary approach

Increased expression of endothelial lipase in symptomatic and unstable carotid plaques

The aim of this study was to evaluate endothelial lipase (EL) protein expression in advanced human carotid artery plaques (HCAP) with regard to plaque (in)stability and the incidence of symptoms. HCAP were collected from 66 patients undergoing carotid endarterectomy (CEA). The degree of plaque (in)stability was estimated by ultrasound and histology. In HCAP sections, EL expression was determined by immunostaining and the intensity was assessed on a semi-quantitative scale (low: <25%, high: >25% positive cells). Monocytes and macrophages in adjacent HCAP sections were stained with a CD163 specific antibody. High EL staining was more prevalent in histologically unstable plaques (in 33.3% of fibrous plaques, 50% of ulcerated non-complicated plaques and 79.2% of ulcerated complicated plaques; χ2 test, p = 0.004) and in the symptomatic group (70.8 vs. 42.9% in the asymptomatic group; χ2 test, p = 0.028). The majority of EL immunostaining was found in those HCAP regions exhibiting a strong CD163 immunostaining. EL in HCAP might be a marker and/or promoter of plaque instability and HCAP-related symptomatology

Analysis of Industrial Product Sound by Applying Image Similarity Measures

The sounds of certain industrial products (machines) carry important information about these products. Product classification or malfunction detection can be performed utilizing a product&rsquo;s sound. In this regard, sound can be used as it is or it can be mapped to either features or images. The latter enables the implementation of recently achieved performance improvements with respect to image processing. In this paper, the sounds of seven industrial products are mapped into mel-spectrograms. The similarities of these images within the same class (machine type) and between classes, representing the intraclass and interclass similarities, respectively, are investigated. Three often-used image similarity measures are applied: Euclidean distance (ED), the Pearson correlation coefficient (PCC), and the structural similarity index (SSIM). These measures are mutually compared to analyze their behaviors in a particular use-case. According to the obtained results, the mel-spectrograms of five classes are similar, while two classes have unique properties manifested in considerably larger intraclass as opposed to interclass similarity. The applied image similarity measures lead to similar general results showing the same main trends, but there are differences among them as mutual relationship of similarity among classes. The differences between the images are more blurred when the SSIM is applied than using ED and the PCC

Analysis of Industrial Product Sound by Applying Image Similarity Measures

The sounds of certain industrial products (machines) carry important information about these products. Product classification or malfunction detection can be performed utilizing a product’s sound. In this regard, sound can be used as it is or it can be mapped to either features or images. The latter enables the implementation of recently achieved performance improvements with respect to image processing. In this paper, the sounds of seven industrial products are mapped into mel-spectrograms. The similarities of these images within the same class (machine type) and between classes, representing the intraclass and interclass similarities, respectively, are investigated. Three often-used image similarity measures are applied: Euclidean distance (ED), the Pearson correlation coefficient (PCC), and the structural similarity index (SSIM). These measures are mutually compared to analyze their behaviors in a particular use-case. According to the obtained results, the mel-spectrograms of five classes are similar, while two classes have unique properties manifested in considerably larger intraclass as opposed to interclass similarity. The applied image similarity measures lead to similar general results showing the same main trends, but there are differences among them as mutual relationship of similarity among classes. The differences between the images are more blurred when the SSIM is applied than using ED and the PCC

Fractional flow reserve of intermediate lesions on collateral donor coronary arteries after myocardial infarction

Fractional flow reserve (FFR) is the gold standard for the functional assessment of coronary arteries. The aim of this study was to evaluate the relation between angiography, QCA and FFR in borderline lesions on collateral donor coronary arteries. In addition, FFR is compared with the angiographic appearance of collaterals to infarction-related arteries and echocardiographically assessed viability of infarct related the LV wall. In 60 patients with previous IM and occluded IRA, functional assessment of borderline coronary stenosis (30-70% DS) on collaterals donor artery was performed. We have not found statistically significant differences in these parameters between groups with different angiographic appearances of collaterals and different viability of distal myocardium. However, we found higher FFR values in diabetic patients (p=0.018). Higher FFR values in diabetic patients reveal the negative effects of diabetes on collateral growth and myocardial viability

Effects of different production systems on carcass and meat quality of sheep and lamb from Western Balkan and Norway

The identification of meat quality characteristics from selected breeds grazing in specific regions is particularly relevant to achieve a marketing advantage. Longisimus thoracis at lumborum (LTL) from the indigenous Western Balkan (WB) sheep - Vlašićka Pramenka (VP) sheep and lambs, and Pivska Pramenka (PP) sheep grazing in Bosnia & Herzegovina (B&H) and Montenegro (MN), respectively, was compared regarding carcass and meat qualities to the crossbred Norwegian white sheep (NWS) - sheep and lambs, grazing in wide Hardangervidda and Jotunheimen regions where the lamb meat is marketed as gourmet meat. The WB sheep had lower average carcass weights and antioxidant capacity, higher ultimate pH, intramuscular fat and n-6/n-3 ratio, but better tenderness and color stability compared to NWS. The WB lambs were lighter, had higher n-6/n-3 ratio, lower antioxidant capacity and became more easily rancid despite a higher fat α-tocopherol content. The marketing advantage of WB meat is its tenderness properties while NO's NWS lambs displayed a better nutritional profile

Oxidative Stress Parameters in Goitrogen-Exposed Crested Newt Larvae (Triturus spp.): Arrested Metamorphosis

Thiourea is an established disruptor of thyroid hormone synthesis and is frequently used as an inhibitor of metamorphosis. The changes caused by thiourea can affect processes associated with the oxidative status of individuals (metabolic rate, the HPI axis, antioxidant system). We investigated the parameters of oxidative stress in crested newt (Triturus spp.) larvae during normal development in late larval stage 62 and newly metamorphosed individuals, and during thiourea-stimulated metamorphosis arrest in individuals exposed to low (0.05%) and high (0.1%) concentrations of thiourea. Both groups of crested newts exposed to thiourea retained their larval characteristics until the end of the experiment. The low activities of antioxidant enzymes and the high lipid peroxidation level pointed to increased oxidative stress in larvae at the beginning of stage 62 as compared to fully metamorphosed individuals. The activities of catalase (CAT) and glutathione-S-transferase (GST) and the concentration of sulfhydryl (SH) groups were significantly lower in larvae reared in aqueous solutions containing thiourea than in newly metamorphosed individuals. The high thiourea concentration (0.1%) affected the antioxidative parameters to the extent that oxidative damage could not be avoided, contrary to a lower concentration. Our results provide a first insight into the physiological adaptations of crested newts during normal development and simulated metamorphosis arrest