Universality and correlations in individuals wandering through an online extremist space

The 'out of the blue' nature of recent terror attacks and the diversity of apparent motives, highlight the importance of understanding the online trajectories that individuals follow prior to developing high levels of extremist support. Here we show that the physics of stochastic walks, with and without temporal correlation, provides a unifying description of these online trajectories. Our unique dataset comprising all users of a global social media site, reveals universal characteristics in individuals' online lifetimes. Our accompanying theory generates analytical and numerical solutions that describe the characteristics shown by individuals that go on to develop high levels of extremist support, and those that do not. The existence of these temporal and also many-body correlations suggests that existing physics machinery can be used to quantify and perhaps mitigate the risk of future events

Connection of the emotional intellect and the emotional burnout of students

The aim of the publication is to present the research results of the connection between the emotional intellect and the emotional burnout among the students of pedagogical college; and disclose the peculiarities of this conection.Methods. Theoretical and methodological bases of work are concepts of «Emotional Intelligence» by D. V. Lyusin and «MBI» (Ch. Maslach and S. Jackson, adaptation by N. E. Vodopyanova), ideas by D. Goulman, R. Cooper; and also approaches to research of emotional intelligence by P. Sulloway and J. Meyer.Results. Data on correlation of emotional intelligence and emotional burnout of students of pedagogical specialties are obtained and described. Phases of manifestation of burnout and levels of formation of intelligence are revealed. The stated research makes a contribution to further studying of the emotional and strong-willed sphere of young men and girls, expands ideas of the nature of emotional intelligence and a syndrome of burning out and gives the chance to plan the further directions of prevention and correction of this syndrome at students through development of their emotional intelligence. These actions will allow to include internal resources for resistance to stress increase that will promote success and competitiveness of the personality in the modern world.Scientific novelty. The connection of emotional intelligence and a syndrome of emotional burnout among young people of student's age is considered for the first time. Results of empirical part of work prove existence of inverse relation of emotional burnout and emotional intelligence that allows to conduct further more in-depth studies in this sphere.Practical significance. Results of the presented research can be used in practical activities of psychologists for development of the correctional developing programs of an emotional condition of students.Цель статьи – представить результаты исследования связи эмоционального интеллекта с эмоциональным выгоранием у студентов педагогического вуза и раскрыть особенности этой связи. Методология исследования. Теоретико-методологическими основами работы явились концепции «ЭмИн» Д. В. Люсина и «MBI» (К. Маслач и С. Джексон, адаптация Н. Е. Водопьяновой), идеи Д. Гоулмана, Р. Купера, а также подходы к исследованию эмоционального интеллекта П. Салоуэя и Дж. Мэйера. Результаты. Получены и описаны данные о корреляции эмоционального интеллекта и эмоционального выгорания у студентов педагогических специальностей. Выявлены фазы проявления выгорания и уровни сформированности интеллекта. Изложенное исследование вносит вклад в дальнейшее изучение эмоционально-волевой сферы юношей и девушек, расширяет представления о природе эмоционального интеллекта и синдрома выгорания и дает возможность наметить дальнейшие направления профилактики и коррекции данного синдрома у студентов через развитие их эмоционального интеллекта. Эти мероприятия позволят включить внутренние ресурсы для повышения стрессоустойчивости, что будет способствовать успешности и конкурентоспособности личности в современном мире. Научная новизна работы состоит в том, что впервые рассматривается связь эмоционального интеллекта и синдрома эмоционального выгорания у молодых людей студенческого возраста. Результаты эмпирической части работы доказывают наличие обратной зависимости эмоционального выгорания и эмоционального интеллекта, что позволяет в дальнейшем проводить более глубокие исследования в данной сфере. Практическая значимость. Представленные материалы можно использовать в практической деятельности психологов для разработки коррекционно-развивающих программ эмоционального состояния студенто

Problems of social adaptation of first-year college students

The article deals with the problem of the relationship of anxiety and social adaptation to training in college freshmen. The student enters some new, unknown to him surroundings. At this stage it is important to cope with the strain, quickly and effectively adapt to the new situationВ работе выявлена проблема взаимосвязи тревожности и социальной адаптации к обучению в колледже у студентов-первокурсников. Студент попадает в новую, неизвестную ему среду, на этом этапе важно справиться с напряжением, быстро и эффективно адаптироваться к новой ситуаци

Value of Safety of Anticoagulant Therapy in Elderly Patient with Atrial Fibrillation and High Risk of Bleeding

The review article discusses  the safety issue of anticoagulant therapy in elderly patients with atrial fibrillation and high risk of bleeding.  An evidence base is presented demonstrating the high safety of rivaroxaban in patients over 80  years of age,  with a high risk of bleeding  and cardiovascular complications,  the presence of comorbid  pathology, geriatric syndromes  and chronic kidney disease (including in combination with anemia). The problem of low adherence to treatment in elderly patients and the possibility of solving it were separately considered

Fortification of food with micronutrients: development of methodological and regulatory framework in the Russian Federation

The available scientific literature, domestic and international regulatory codes of normative documents concerning the fortification of various types of food products have been analyzed. The groups of food products of conventional and regular consumption included into the diets of all categories of consumers, recommended for fortification with essential micronutrients, have been determined: wheat and cereal flour (spelt wheat, buckwheat, oat, corn flour, etc.); pastry; milk and dairy products, including ice cream; non-alcoholic soft drinks; mineralized drinking water; fruit and vegetable juices; fat and oil products (vegetable oils, margarines, spreads, mayonnaise); confectionery and sweets (pastry, sugar, chocolate); cereals (breakfast cereals, muesli, ready-to-eat extruded cereals, instant pasta and cereals, mixtures for bakery, flour for sweet pastry); food concentrates (jelly, instant drinks, concentrates of sweet foods, instant food, instant cereal concentrates); table salt. The groups of food products assigned for certain categories of population are used as part of therapeutic diets for patients with various diseases (metabolic disorder syndrome, cardio-vascular system pathology with atherosclerotic vascular injury, type 2 diabetes mellitus, gastrointestinal tract diseases, non-alcoholic fatty liver disease, diabetic nephropathy, etc.), as well as assigned to reduce the risk of diseases developing, the nutrients are recommended for targeted fortification of certain types of food. Examples of micronutrients fortification of sausages and minced meat semifinished products are given below. Requirements for fortification of mass consumption food products and for fortification of foods for special dietary uses are formulated in this article, the amount of fortifying components in the various groups of food products are justified, ensuring their efficiency for improving the micronutrient status and safety of its consumption. Based on the analysis of the available scientific literature, domestic and international regulatory framework of normative documents on fortification of various types of food products, recommendations have been developed for fortification of food with micronutrients

Mechanisms of transcriptional regulation of ecdysone response

The mechanisms of ecdysone-dependent expression have been studied for many decades. Initially, the activation of individual genes under the influence of ecdysone was studied on the model of polythene chromosomes from salivary glands of Drosophila melanogaster. These works helped to investigate the many aspects of the Drosophila development. They also revealed plenty of valuable information regarding the fundamental mechanisms controlling the genes’ work. Many years ago, a model describing the process of gene activation by ecdysone, named after the author – Ashburner model – was proposed. This model is still considered an excellent description of the ecdysone cascade, which is implemented in the salivary glands during the formation of the Drosophila pupa. However, these days there is an opinion that the response of cells to the hormone ecdysone can develop with significant differences, depending on the type of cells. The same genes can be activated or repressed under the influence of ecdysone in different tissues. Likely, certain DNA-binding transcription factors that are involved in the ecdysonedependent response together with the EcR/Usp heterodimer are responsible for cell-type specificity. A number of transcriptional regulators involved in the ecdysone response have been described. Among them are several complexes responsible for chromatin remodeling and modification. It has been shown by various methods that ecdysone-dependent activation/repression of gene transcription develops with significant structural changes of chromatin on regulatory elements. The description of the molecular mechanism of this process, in particular, the role of individual proteins in it, as well as structural interactions between various regulatory elements is a matter of the future. This review is aimed to discuss the available information regarding the main regulators that interact with the ecdysone receptor. We provide a brief description of the regulator’s participation in the ecdysone response and links to the corresponding study. We also discuss general aspects of the mechanism of ecdysone-dependent regulation and highlight the most promising points for further research

PSYCHOLOGICAL ASPECTS OF INVOLVEMENT OF YOUNG PEOPLE IN EXTREMIST GROUPS IN THE INTERNET ENVIRONMENT

Abstract. The aim of the article is to consider the psychological characteristics of involvement of youth in extremist community through the Internet. Methods. The theoretical analysis and modeling were used as the main methods.Results. The Internet is described as a means and space of psychological influence on young people, which can be both positive and negative. Absorption of teenagers, boys and young men, in a virtual space essentially converts their activity and, as a result, transform the leading activity, which in turn leads to different mental tumors. Three main effects from the exposure of the Internet are found out: «the effect of the goals of drift», mythology and «the effect of excitement»; their impact on the individual in each age periods is noted. Consideration of the main motivational reasons, taking into account the specifics of building human interaction with the environment made it possible to identify and describe the main types of behavioural patterns exhibited by young people on the Internet. The degree of activity of young people in the network is described from the perspective of integrated strategies of behaviour: information blocking, changes in the distance, control, transformations. Risk groups of users, the most susceptible to extremist manipulations are designated. «Vulnerability areas» of representatives of each group are summarized and described; a step-by-step algorithm of victims’ involvement in extremist communities by recruiters is described.Scientific novelty of the present study consists in discussion of one of the most acute problems of the present – the changed conditions of a growing and socialization of younger generation; constant stay in network virtual space is an integral part of today’s existence, wherein unformed and immature person is very vulnerable to the influence of extremist content. To prevent the increased potential threat of involvement of young people in destructive, asocial and criminal activity, the authors suggest to draw close attention and to subject to the purposeful attacks of extremist communities. Detailed studying of social and psychological features of network behaviour of youth being affected by the dangerous content will help to provide well-timed prophylaxis of extremist moods among young people.Practical significance. The materials of the research can be used to identify and effectively prevent the influence of extremist groups on young Internet users.Исследование выполнено при финансовой поддержке РФФИ в рамках научно- исследовательского проекта «Интернет как инструмент формирования психологической готовности молодежи к экстремистскому поведению», проект № 16-29-09512Исследование выполнено при финансовой поддержке РФФИ в рамках научно- исследовательского проекта «Интернет как инструмент формирования психологической готовности молодежи к экстремистскому поведению», проект № 16-29-0951

Mg2+ activation of Escherichia coli inorganic pyrophosphatase

AbstractFurther refinement of X-ray data on Escherichia coli inorganic pyrophosphatase [Oganessyan et al. (1994) FEBS Lett. 348, 301–304] to 2.2 Å reveals a system of noncovalent interactions involving Tyr55 and Tyr141 in the active site. The pKa for one of the eight Tyr residues in wild-type pyrophosphatase is as low as 9.1 and further decreases to 8.1 upon Mg2+ binding, generating characteristic changes in the absorption spectrum. These effects are lost in a Y55F but not in a Y141F variant. It is suggested that the lower-affinity site for Mg2+ in the enzyme is formed by Tyr55 and Asp70, which are in close proximity in the apo-enzyme structure