PREPARATION AND EVALUATION OF POLYMERIC NANOPARTICLES OF GLIBENCLAMIDE

Simple, reliable and reproducible method was used for the preparation of polymeric nanoparticles of Glibenclamide. The formulation was prepared by solvent evaporation method using magnetic stirrer with overnight stirring and the same was then evaluated for its particle size, drug content and in vitro dissolution studies. The above mentioned method showed similar particle size and exhibited an improvement in the drug entrapment efficiency. The ultraviolet spectrophotometric method was used to analyze Glibenclamide at 300 nm in different buffers. The study demonstrated the successful preparation of sustained release polymeric nanoparticles of Glibenclamide. Keywords: Glibenclamide, polymeric nanoparticles, solvent evaporatio