Isoscalar giant monopole strength in 58^{58}Ni, 90^{90}Zr, 120^{120}Sn and 208^{208}Pb

Inelastic $\alpha$-particle scattering at energies of a few hundred MeV and very-forward scattering angles including $0^\circ$ has been established as a tool for the study of the isoscalar giant monopole (IS0) strength distributions in nuclei. An independent investigation of the IS0 strength in nuclei across a wide mass range was performed using the $0^\circ$ facility at iThemba Laboratory for Accelerator Based Sciences (iThemba LABS), South Africa, to understand differences observed between IS0 strength distributions in previous experiments performed at the Texas A\&M University (TAMU) Cyclotron Institute, USA and the Research Center for Nuclear Physics (RCNP), Japan. The isoscalar giant monopole resonance (ISGMR) was excited in $^{58}$Ni, $^{90}$Zr, $^{120}$Sn and $^{208}$Pb using $\alpha$-particle inelastic scattering with $196$ MeV $\alpha$ beam and scattering angles $\theta_{\text{Lab}} = 0^\circ$ and $4^\circ$. The K$600$ magnetic spectrometer at iThemba LABS was used to detect and momentum analyze the inelastically scattered $\alpha$ particles. The IS0 strength distributions in the nuclei studied were deduced with the difference-of-spectra (DoS) technique including a correction factor for the $4^\circ$ data based on the decomposition of $L > 0$ cross sections in previous experiments. IS0 strength distributions for $^{58}$Ni, $^{90}$Zr, $^{120}$Sn and $^{208}$Pb are extracted in the excitation-energy region $E_{\rm x} = 9 - 25$ MeV.Using correction factors extracted from the RCNP experiments, there is a fair agreement with their published IS0 results. Good agreement for IS0 strength in $^{58}$Ni is also obtained with correction factors deduced from the TAMU results, while marked differences are found for $^{90}$Zr and $^{208}$Pb.Comment: 12 pages, 10 figures, regular article submitted to PR

Fine structure of the isoscalar giant monopole resonance in 58^{58}Ni, 90^{90}Zr, 120^{120}Sn and 208^{208}Pb

Over the past two decades high energy-resolution inelastic proton scattering studies were used to gain an understanding of the origin of fine structure observed in the isoscalar giant quadrupole resonance (ISGQR) and the isovector giant dipole resonance (IVGDR). Recently, the isoscalar giant monopole resonance (ISGMR) in $^{58}$Ni, $^{90}$Zr, $^{120}$Sn and $^{208}$Pb was studied at the iThemba Laboratory for Accelerator Based Sciences (iThemba LABS) by means of inelastic $\alpha$-particle scattering at very forward scattering angles (including $0\circ$). The good energy resolution of the measurement revealed significant fine structure of the ISGMR.~To extract scales by means of wavelet analysis characterizing the observed fine structure of the ISGMR in order to investigate the role of different mechanisms contributing to its decay width. Characteristic energy scales are extracted from the fine structure using continuous wavelet transforms. The experimental energy scales are compared to different theoretical approaches performed in the framework of quasiparticle random phase approximation (QRPA) and beyond-QRPA including complex configurations using both non-relativistic and relativistic density functional theory. All models highlight the role of Landau fragmentation for the damping of the ISGMR especially in the medium-mass region. Models which include the coupling between one particle-one hole (1p-1h) and two particle-two hole (2p-2h) configurations modify the strength distributions and wavelet scales indicating the importance of the spreading width. The effect becomes more pronounced with increasing mass number. Wavelet scales remain a sensitive measure of the interplay between Landau fragmentation and the spreading width in the description of the fine structure of giant resonances.Comment: 13 pages,7 figures, regular articl

A high energy-resolution zero degree facility for (p,p′) and (p,t) reactions

Medium-energy hadronic scattering and reactions at zero degrees are very selective to excitations with low angular momentum transfer. Only a few facilities exist worldwide where high energy-resolution measurements of this nature can be performed. The K600 Zero-Degree Facility at iThemba LABS, South Africa, was recently successfully developed. Measurements were performed for inelastic proton scattering at an incident energy of 200 MeV for targets ranging from ²⁷Al to ²⁰⁸Pb. Excitation energy-resolution of 50 keV (FWHM) was achieved. A reasonable background subtraction procedure allows for the extraction of excitation energy spectra with low background. Measurements of the (p,t) reaction at 100 MeV benefit from a large difference in magnetic rigidity between the reaction products and primary particles, resulting in almost background-free spectra with excitation energy-resolution of 32 keV (FWHM)

The evolving SARS-CoV-2 epidemic in Africa: insights from rapidly expanding genomic surveillance

Investment in SARS-CoV-2 sequencing in Africa over the past year has led to a major increase in the number of sequences generated, now exceeding 100,000 genomes, used to track the pandemic on the continent. Our results show an increase in the number of African countries able to sequence domestically, and highlight that local sequencing enables faster turnaround time and more regular routine surveillance. Despite limitations of low testing proportions, findings from this genomic surveillance study underscore the heterogeneous nature of the pandemic and shed light on the distinct dispersal dynamics of Variants of Concern, particularly Alpha, Beta, Delta, and Omicron, on the continent. Sustained investment for diagnostics and genomic surveillance in Africa is needed as the virus continues to evolve, while the continent faces many emerging and re-emerging infectious disease threats. These investments are crucial for pandemic preparedness and response and will serve the health of the continent well into the 21st century

A year of genomic surveillance reveals how the SARS-CoV-2 pandemic unfolded in Africa

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Baseline characteristics of patients in the reduction of events with darbepoetin alfa in heart failure trial (RED-HF)

<p>Aims: This report describes the baseline characteristics of patients in the Reduction of Events with Darbepoetin alfa in Heart Failure trial (RED-HF) which is testing the hypothesis that anaemia correction with darbepoetin alfa will reduce the composite endpoint of death from any cause or hospital admission for worsening heart failure, and improve other outcomes.</p> <p>Methods and results: Key demographic, clinical, and laboratory findings, along with baseline treatment, are reported and compared with those of patients in other recent clinical trials in heart failure. Compared with other recent trials, RED-HF enrolled more elderly [mean age 70 (SD 11.4) years], female (41%), and black (9%) patients. RED-HF patients more often had diabetes (46%) and renal impairment (72% had an estimated glomerular filtration rate <60 mL/min/1.73 m2). Patients in RED-HF had heart failure of longer duration [5.3 (5.4) years], worse NYHA class (35% II, 63% III, and 2% IV), and more signs of congestion. Mean EF was 30% (6.8%). RED-HF patients were well treated at randomization, and pharmacological therapy at baseline was broadly similar to that of other recent trials, taking account of study-specific inclusion/exclusion criteria. Median (interquartile range) haemoglobin at baseline was 112 (106–117) g/L.</p> <p>Conclusion: The anaemic patients enrolled in RED-HF were older, moderately to markedly symptomatic, and had extensive co-morbidity.</p&gt

Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries.

BACKGROUND: As global initiatives increase patient access to surgical treatments, there remains a need to understand the adverse effects of surgery and define appropriate levels of perioperative care. METHODS: We designed a prospective international 7-day cohort study of outcomes following elective adult inpatient surgery in 27 countries. The primary outcome was in-hospital complications. Secondary outcomes were death following a complication (failure to rescue) and death in hospital. Process measures were admission to critical care immediately after surgery or to treat a complication and duration of hospital stay. A single definition of critical care was used for all countries. RESULTS: A total of 474 hospitals in 19 high-, 7 middle- and 1 low-income country were included in the primary analysis. Data included 44 814 patients with a median hospital stay of 4 (range 2-7) days. A total of 7508 patients (16.8%) developed one or more postoperative complication and 207 died (0.5%). The overall mortality among patients who developed complications was 2.8%. Mortality following complications ranged from 2.4% for pulmonary embolism to 43.9% for cardiac arrest. A total of 4360 (9.7%) patients were admitted to a critical care unit as routine immediately after surgery, of whom 2198 (50.4%) developed a complication, with 105 (2.4%) deaths. A total of 1233 patients (16.4%) were admitted to a critical care unit to treat complications, with 119 (9.7%) deaths. Despite lower baseline risk, outcomes were similar in low- and middle-income compared with high-income countries. CONCLUSIONS: Poor patient outcomes are common after inpatient surgery. Global initiatives to increase access to surgical treatments should also address the need for safe perioperative care. STUDY REGISTRATION: ISRCTN5181700

ISSN exercise & sport nutrition review: research & recommendations

Sports nutrition is a constantly evolving field with hundreds of research papers published annually. For this reason, keeping up to date with the literature is often difficult. This paper is a five year update of the sports nutrition review article published as the lead paper to launch the JISSN in 2004 and presents a well-referenced overview of the current state of the science related to how to optimize training and athletic performance through nutrition. More specifically, this paper provides an overview of: 1.) The definitional category of ergogenic aids and dietary supplements; 2.) How dietary supplements are legally regulated; 3.) How to evaluate the scientific merit of nutritional supplements; 4.) General nutritional strategies to optimize performance and enhance recovery; and, 5.) An overview of our current understanding of the ergogenic value of nutrition and dietary supplementation in regards to weight gain, weight loss, and performance enhancement. Our hope is that ISSN members and individuals interested in sports nutrition find this review useful in their daily practice and consultation with their clients

A year of genomic surveillance reveals how the SARS-CoV-2 pandemic unfolded in Africa.

The progression of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic in Africa has so far been heterogeneous, and the full impact is not yet well understood. In this study, we describe the genomic epidemiology using a dataset of 8746 genomes from 33 African countries and two overseas territories. We show that the epidemics in most countries were initiated by importations predominantly from Europe, which diminished after the early introduction of international travel restrictions. As the pandemic progressed, ongoing transmission in many countries and increasing mobility led to the emergence and spread within the continent of many variants of concern and interest, such as B.1.351, B.1.525, A.23.1, and C.1.1. Although distorted by low sampling numbers and blind spots, the findings highlight that Africa must not be left behind in the global pandemic response, otherwise it could become a source for new variants