The predominance of social proximity for innovation collaboration of SME

The paper at hand contributes to the field of proximity studies with a focus on social proximity. The paper gives an in-depth discussion of a theoretical and empirical definition of social proximity. Based on this, an argumentation follows why social proximity is of particular importance when the decision for external innovation collaboration partners has to be made. This holds especially for SME and for firms with low or medium innovativeness. Furthermore, the paper presents two explorative case studies as a first support for the developed theory. The analysis of two firms shows how social proximity guides the search for collaboration partners

How individual characteristics and attitudes shape the job search process of graduates.

Economic factors and individual attitudes have an impact on the mobility of university graduates. At this point of the life, mobility is highest, but still little is known about the process leading to actually starting a job at a certain place. The paper at hand investigates the job search process by means of a graduate survey at two points in time: prior to graduation and one year later. We asked for individual characteristics and attitudes during the job search, ex ante preferred places, and actual locations of the first job. Hence, we are able to show that a spatial focus or certain attitudes during the search do not have an influence on finding a job, but on the duration of the job search. Furthermore, searching at a familiar place does not necessarily lead to a job actually at a familiar place

Inventor collaboration over distance - a comparison of academic and corporate patents

The paper compares academic and corporate patents in Germany to shed light on the geographical distribution of the inventors. The residences of the inventors show different patterns in the two datasets. Furthermore, we analyze the spatial distance between inventors for patents invented in collaboration and give insights into the distance's change over a time period of 14 years. The distance between collaborating inventors of corporate patents exceeds that of inventors of academic patents. In spite of the rise of ICT and cheap passenger transportation the collaboration distances have not increased. This supports earlier literature on the importance of proximity in innovation

The Dynamics of Inter-Regional Collaboration - An Analysis of Co-Patenting

The paper at hand investigates how co-patenting over distance develops when aggregating inventive activities on a regional level. That means, the object of analysis is a link between two regions in contrast to other studies, where links between two individuals or firms are investigated. We analyse which regional characteristics influence the creation and continuation of such links. The main focus lies on different types of distance. The approach adds a dynamic view to the existing, often static literature about collaboration behaviour. The regressions are done for all patent-relevant industries in Germany. We find that several distance types decrease - as expected - the likelihood of link creation but also - not in all cases expected - of link continuation

The organizational and regional determinants of inter-regional collaborations - Academic inventors as bridging agents

Collaboration over distance is difficult to maintain in innovation projects which require a great deal of regional collaboration. However, patent documents reveal that a number of inventor teams are able to overcome long distances. Earlier literature started to investigate factors, which increase the probability of long-distance innovation co-operation. The paper at hand is restricted to patents with academic participation, but takes a close look at two types of factors in the environment of the inventors: (1) the characteristics of the university that employs the academic inventor(s), and (2) the influence of the regional environment. Research on the impact of these factors is still underdeveloped in the literature. By considering only patents with at least one academic inventor we have a relatively homogeneous subset of patents and can concentrate on the external impacts. We find that a similar research area structure, a high absorptive capacity as well as a high start-up rate foster intra-regional collaboration. More TTO staff and a larger university lead to more long-distance collaboration while the industry orientation of the university does not exert an influence on the distance between inventors

Motives behind the mobility of university graduates - A study of three German universities

The mobility of university graduates is influenced by economic factors and individual attitudes. The paper at hand focuses on individual characteristics influencing the spatial preferences of graduates from three universities in Hesse (Germany). Using survey data from prospective graduates in 2012 we find that the majority has preferred locations during the job search, which are on average farther away if the respondents focus on broad availability of job opportunities and leisure/cultural activities. Social ties and a focus on good infrastructure leads to a search dominantly at familiar places, i.e. the home or university region

Co-operation over Distance? The Spatial Dimension of Inter-organisational Innovation Collaboration

In the literature there is a controversy about the relevance of the spatial dimension in innovation collaboration. We examine the link between the spatial composition of group members and group characteristics which are important for performing innovation projects. To this end, we introduce a social-psychological approach to the field of economic geography. The empirical part is a longitudinal study of 49 inter-organisational innovation groups in Germany. We find that the share of regional partners is rather stable after a funded formation stage. Hence, policy measures aiming at inter-regional collaboration have to be employed at an early stage of group development

The structure and dynamics of R and D collaborations in Europe and the USA (A longitudinal and comparative perspective)

Today it is generally accepted that innovation, knowledge creation, and the diffusion of new knowledge are crucial factors for economic growth at the regional, national, as well as supra-national level, and that successful innovation is increasingly based on interactions and collaborative research activities between research actors. This study focuses on diverse dimensions of distance shaping R and D collaborations in Europe and the US during the time period 1999 to 2009. We take a comparative perspective by analyzing two different R and D collaboration networks (patents and publications) and two different economic areas, namely Europe and the US, in order to examine differences in collaboration activities. In particular, we investigate how the collaboration intensity between regions has been influenced by spatial, technological, and cultural distance and whether these distances have lost importance over time in the distinct networks. The study adopts a panel spatial interaction modeling perspective. In doing so, we explicitly take account of spatial autocorrelation issues of flows by means of Eigenvector spatial filtering techniques. European coverage is achieved by using 1260 NUTS-3 regions of the 25 pre-2007 EU member-states, as well as Norway and Switzerland. The US coverage is attained by using 955 core based statistical areas (CBSAs). The results reveal how collaborative knowledge creation and the spatial range of knowledge diffusion differs between Europe and the US, and provide direct evidence on the differences in cooperation patterns between different types of collaborative R and D from a longitudinal and comparative perspectiv

Crystal Structure of Human TWEAK in Complex with the Fab Fragment of a Neutralizing Antibody Reveals Insights into Receptor Binding.

The tumor necrosis factor-like weak inducer of apoptosis (TWEAK) is a multifunctional cytokine playing a key role in tissue regeneration and remodeling. Dysregulation of TWEAK signaling is involved in various pathological processes like autoimmune diseases and cancer. The unique interaction with its cognate receptor Fn14 makes both ligand and receptor promising targets for novel therapeutics. To gain insights into this important signaling pathway, we determined the structure of soluble human TWEAK in complex with the Fab fragment of an antibody selected for inhibition of receptor binding. In the crystallized complex TWEAK is bound by three Fab fragments of the neutralizing antibody. Homology modeling shows that Fab binding overlaps with the putative Fn14 binding site of TWEAK. Docking of the Fn14 cysteine rich domain (CRD) to that site generates a highly complementary interface with perfectly opposing charged and hydrophobic residues. Taken together the presented structure provides new insights into the biology of TWEAK and the TWEAK/Fn14 pathway, which will help to optimize the therapeutic strategy for treatment of related cancer types and autoimmune diseases

The Diversity Factor: How Cultural Diversity Impacts Innovations in Germany

The 2018 Reinhard Mohn Prize on “Living Diversity – Shaping Society” is meant to bring new momentum and perspectives to how Germany lives diversity and shapes society. The present study “The Diversity Factor – How Cultural Diversity Impacts Innovations in Germany” examines the question of whether and how cultural diversity affects the innovative power of both companies and society. There is much to suggest that a culturally diverse workforce – e.g. people with different experiences, mindsets and interpretive contexts – fosters creativity and innovation. The current publication is based on evaluations of empirical studies that examine the correlation between cultural diversity and innovation. This analysis of the literature was carried out using a narrow definition of cultural diversity, one that includes, in particular, the dimensions of “ethnicity,” “religion/world view” and “nationality.” Innovation was measured in each study based on the number of patents, patent citations or companies’ self-assessments of their product and process innovations or overall factor productivity. The results of this research were then considered more deeply in interviews and conversations with business experts, public administrators and civil society leaders