Flight Investigation using Variable-Stability Airplanes of Minimum Stability Requirements for High-Speed, High-Altitude Vehicles

The pilot opinion of the flying qualities of vehicles covering a wide range of longitudinal dynamic characteristics has been determined by the use of a variable-stability airplane. Particular emphasis has been placed on determining the minimum level of stability and control characteristics that the pilot can cope with. There was considerable pilot learning associated with operation in the regions of poor stability characteristics. In the statically stable region the maximum acceptable value of time to damp to half amplitude of the longitudinal mode for normal operation was about 1 second. For emergency conditions the damping could be reduced to zero over most of the frequency range. The extreme lim it of controllability corresponded to a time to double amplitude of the oscillation of about 1 - 1/2 seconds. In the statically unstable region somewhat shorter times to double amplitude were acceptable to the pilots. The boundary for emergency operation corresponded roughly to time to double amplitude of about 2/3 second and the limit of controllability of about l/3 second

Significant Association of Multiple Human Cytomegalovirus Genomic Loci with Glioblastoma Multiforme Samples

Viruses are appreciated as etiological agents of certain human tumors, but the number of different cancer types induced or exacerbated by viral infections is unknown. Glioblastoma multiforme (GBM)/astrocytoma grade IV is a malignant and lethal brain cancer of unknown origin. Over the past decade, several studies have searched for the presence of a prominent herpesvirus, human cytomegalovirus (HCMV), in GBM samples. While some have detected HCMV DNA, RNA, and proteins in GBM tissues, others have not. Therefore, any purported association of HCMV with GBM remains controversial. In most of the previous studies, only one or a select few viral targets were analyzed. Thus, it remains unclear the extent to which the entire viral genome was present when detected. Here we report the results of a survey of GBM specimens for as many as 20 different regions of the HCMV genome. Our findings indicate that multiple HCMV loci are statistically more likely to be found in GBM samples than in other brain tumors or epileptic brain specimens and that the viral genome was more often detected in frozen samples than in paraffin-embedded archival tissue samples. Finally, our experimental results indicate that cellular genomes substantially outnumber viral genomes in HCMV-positive GBM specimens, likely indicating that only a minority of the cells found in such samples harbor viral DNA. These data argue for the association of HCMV with GBM, defining the virus as oncoaccessory. Furthermore, they imply that, were HCMV to enhance the growth or survival of a tumor (i.e., if it is oncomodulatory), it would likely do so through mechanisms distinct from classic tumor viruses that express transforming viral oncoproteins in the overwhelming majority of tumor cells