ХРОНИЧЕСКИЙ ВИРУСНЫЙ ГЕПАТИТ С У ДЕТЕЙ: ПРОБЛЕМЫ И ПЕРСПЕКТИВЫ

The analysis of the problem of chronic hepatitis C (CHC) in children. The data on the incidence of primary CHC child population on the territory of the Russian Federation and abroad. The problems of diagnosis of HCV-infection. Conducted a review of the risk of infection, highlight the possible routes of transmission are shown peculiarities of HCV-infected children, shows the frequency of chronic process. The state of the problem at the moment and evaluated further promise in the treatment of chronic hepatitis C in children. Проведен анализ состояния проблемы хронического гепатита С у детей. Представлены данные по первичной заболеваемости хроническим гепатитом С у детского населения как на территории Российской Федерации, так и за рубежом. Рассмотрены проблемы диагностики HCV-инфекции. Проведен обзорный анализ риска инфицированности, освещены возможные пути передачи, показаны особенности течения HCV-инфекции у детей, отображена частота хронизации процесса. Проанализировано состояние проблемы в настоящее время и оценены дальнейшие перспективы в лечении хронического вирусного гепатита С у детей

ETIOLOGICAL FACTORS OF CHRONIC GASTRITIS IN CHILDREN

In the article the data on the study of the etiological factors of various types of chronic gastritis in children are presented. Based on revealing of the auto antibodies to parietal gastric cells in 40,0% of children autoimmune gastritis (a type gastritis) is diagnosed. Helicobacterr pylori infection is revealed in 44,8% of children. In 27,6% of children type c gastritis is diagnosed. Autoimmune gastritis in children has been linked to the active phase of chronic epsteinbbarr virus infection. the etiological factors of nonautoimmune gastritis are Helicobacter pylori infection (type b gastritis) and multiple duodenogastric refluxes (type c gastritis).Key words: children, chronic gastritis, etiological factors, autoimmune gastritis, nonautoimmune gastritis, active phase of chronic Epstein-Barr virus infection, Helicobacter pylori infection

EFFECTIVENESS OF ANTIVIRAL THERAPY OF CHRONIC VIRAL HEPATITIS C IN CHILDREN

The article describes an efficacy of interferon alpha-2a (Roferon-A) in 69 children with chronic viral hepatitis C. The frequency of forming of initial and prolonged remission and the role of such factors as viral genotype, the level of viral load, terms of elimination of virus, the evidence of histological changes in liver’s parenchyma in prognosis of remission and late relapse development was shown. Authors estimated the safety of the drug.Key words: children, chronic viral hepatitis C, interferon alpha-2a, treatment.(Voprosy sovremennoi pediatrii — Current Pediatrics. 2009;8(6):101-105)</span

EFFECTIVENESS OF ANTIVIRAL THERAPY OF CHRONIC VIRAL HEPATITIS C IN CHILDREN

The article describes an efficacy of interferon alpha-2a (Roferon-A) in 69 children with chronic viral hepatitis C. The frequency of forming of initial and prolonged remission and the role of such factors as viral genotype, the level of viral load, terms of elimination of virus, the evidence of histological changes in liver’s parenchyma in prognosis of remission and late relapse development was shown. Authors estimated the safety of the drug.Key words: children, chronic viral hepatitis C, interferon alpha-2a, treatment.(Voprosy sovremennoi pediatrii — Current Pediatrics. 2009;8(6):101-105