12 research outputs found
Characterization of the binding site of the histamine H3 receptor. 1. Various approaches to the synthesis of 2-(1H-imidazol-4-yl)cyclopropylamine and histaminergic activity of (1R,2R)-and (1S,2S)-2-(1H-imidazol-4-yl)-cyclopropylamine.
Get PDFVarious approaches to the synthesis of all four stereoisomers of 2-(1H- imidazol-4-yl)cyclopropylamine (cyclopropylhistamine) are described. The rapid and convenient synthesis and resolution of trans-cyclopropylhistamine is reported. The absolute configuration of its enantiomers was determined by single-crystal X-ray crystallographic analysis. The distinct transcyclopropylhistamine enantiomers were tested for their activity and affinity on the histamine
The medicinal chemistry and therapeutic potentials of ligands of the histamine H₃ receptor.
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Homologs of histamine as histamine H₃ receptor antagonists: a new potent and selective H₃ antagonist, 4(5)-(5-aminopentyl)-1H-imidazole.
No full textHistamine homologues discriminating between two functional H3 receptor assays. Evidence for H3 receptor heterogeneity?
No full textPharmacological analysis of immepip and imetit homologues. Further evidence for histamine H(3) receptor heterogeneity?
No full textFollowing a previous report by our research group on discriminative properties of a series of aliphatic histamine homologues, we now studied immepip, imetit and its lower and higher sidechain homologues as ligands for the histamine
Characterization of the binding site of the histamine H-3 receptor. I. Various approaches to the synthesis of 2-(1H-imidazol-4-yl)cyclopropylamine and histaminergic activity of (1R,2R)- and (1S,2S)-2-(1H-imidazol-4-yl)cyclopropylamine.
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