Student attitudes to entrepreneurship

This study on Student Attitudes to Entrepreneurship investigates the image which university students have of entrepreneurs and entrepreneurship. It is an initial exploratory/empirical study, which looks at the situation in Germany, Romania, Latvia, Italy and Austria. The study, based on questionnaires, shows that there are significant differences but also common features to the image of entrepreneurship and attitudes to it in the five countries. It is interesting to note that the students polled in connection with the study tended to have a neutral to positive/very positive image of entrepreneurs.attitude, attributes, entrepreneurs, entrepreneurship, opinion.

The role of firm-level and country-level antecedents in explaining emerging versus advanced economy multinationals' R&D internationalization strategies

We examined firm-level and country-level antecedents of R&D internationalization strategies, focusing on differences between enterprises in emerging and advanced economies. Previous research often focuses on the relative importance of home-base-exploiting versus home-base-augmenting knowledge transfer strategies. We suggest that country-level and firm-level effects differ for the two strategies, and hence, we examined each strategy independently. Collecting data in China, India, the United States, and Germany, we demonstrated that firms' relative technological position as a firm-level characteristic can explain differences in home-base-exploiting strategies between emerging and advanced economies. In contrast, home-base-augmenting is more closely related to exploratory institutional environments, a country-level factor. Thus, either firm- or country-level antecedents can gain a dominant role, depending on the strategy implemented

Knowledge transfer and home-market innovativeness:A comparison of emerging and advanced economy multinationals

Emerging market multinational enterprises (EMNEs) increasingly access foreign technology and knowledge by internationalizing their R&D activities. Since technological laggardness hinders efficient knowledge transfer, a successful catch-up with advanced-economy multinational enterprises (AMNEs) requires EMNEs to transfer foreign knowledge across national boundaries more effectively. However, we lack a clear understanding of how EMNEs manage this knowledge transfer and integration and to what extent the employment and effectiveness of corresponding facilitation mechanisms may differ from AMNEs. Adopting a sender-recipient model and drawing on arguments from learning theory and transaction costs economics, we suggest that EMNEs benefit more from and, consequently, are more likely to engage in mechanisms to increase recipient capabilities and sender motivation. In a comparative analysis of Chinese, Indian, German, and U.S. MNEs and focusing on frequent international exchange of R&D personnel regarding recipient capabilities and the governance of foreign R&D activities regarding sender motivation, we observe positive relationships with home-market innovation for EMNEs, but not for AMNEs. Moreover, we observe that EMNEs exploit this positive effect and are more likely to use these mechanisms when focusing on technology- than on market-seeking

Sustainable Insights 2015: Band 1 der Schriftenreihe "Ressourceneffizienz und Nachhaltigkeit im Bergischen Städtedreieck"

Sustainable Insights 2015 - Kongress für Studierende und Werkstatt für verantwortungsvolles Wirtschaften 2015 Wie integrieren Unternehmen Nachhaltigkeitskonzepte in ihre Geschäftspolitik und wie realistisch ist die Umsetzung im Betriebsalltag? Wie bewerten Studierende verschiedener Fachrichtungen Strategien für eine bessere Ressourceneffizienz? Welche Lösungen erarbeiten sie gemeinsam mit Unternehmen? Zwei Tage Nachhaltigkeit im Praxistest – bei Sustainable Insights lernten über 100 Studierende, Young Professionals und Auszubildende aus ganz Deutschland engagierte Unternehmen kennen und entwickelten in Case Studies selbst eigene und praxisnahe Ideen. Diese Publikation dokumentiert den Kongress. Sustainable Insights fand 2015 zum ersten Mal statt, eine Wiederholung ist geplant. Veranstaltet wurde Sustainable Insights von der Neuen Effizienz und dem Team von Prof. Dr. Christine Volkmann, Inhaberin des UNESCOLehrstuhls für Entrepreneurship und Interkulturelles Management an der Bergischen Universität Wuppertal und Vorsitzende des Jackstädtzentrums für Unternehmertums- und Innovationsforschung. Schriftenreihe „Ressourceneffizienz und Nachhaltigkeit im Bergischen Städtedreieck“ Die Schriftenreihe, herausgegeben von der Neuen Effizienz, ist die Plattform für Forschung, Projekte und Veranstaltungen zu Nachhaltigkeit und Ressourceneffizienz im Bergischen Städtedreieck. Sie richtet sich an Wissenschaftler und Studierende, Unternehmer und Experten sowie die interessierte Öffentlichkeit. Die Schriftenreihe ist über den Hochschulschriftenserver der Bergischen Universität sowie www.neue-effizienz.de digital frei verfügbar („Open Access“)

EIF2AK2 Missense Variants Associated with Early Onset Generalized Dystonia

Objective: The study was undertaken to identify a monogenic cause of early onset, generalized dystonia. Methods: Methods consisted of genome-wide linkage analysis, exome and Sanger sequencing, clinical neurological examination, brain magnetic resonance imaging, and protein expression studies in skin fibroblasts from patients. Results: We identified a heterozygous variant, c.388G&gt;A, p.Gly130Arg, in the eukaryotic translation initiation factor 2 alpha kinase 2 (EIF2AK2) gene, segregating with early onset isolated generalized dystonia in 5 patients of a Taiwanese family. EIF2AK2 sequencing in 191 unrelated patients with unexplained dystonia yielded 2 unrelated Caucasian patients with an identical heterozygous c.388G&gt;A, p.Gly130Arg variant, occurring de novo in one case, another patient carrying a different heterozygous variant, c.413G&gt;C, p.Gly138Ala, and one last patient, born from consanguineous parents, carrying a third, homozygous variant c.95A&gt;C, p.Asn32Thr. These 3 missense variants are absent from gnomAD, and are located in functional domains of the encoded protein. In 3 patients, additional neurological manifestations were present, including intellectual disability and spasticity. EIF2AK2 encodes a kinase (protein kinase R [PKR]) that phosphorylates eukaryotic translation initiation factor 2 alpha (eIF2α), which orchestrates the cellular stress response. Our expression studies showed abnormally enhanced activation of the cellular stress response, monitored by PKR-mediated phosphorylation of eIF2α, in fibroblasts from patients with EIF2AK2 variants. Intriguingly, PKR can also be regulated by PRKRA (protein interferon-inducible double-stranded RNA-dependent protein kinase activator A), the product of another gene causing monogenic dystonia. Interpretation: We identified EIF2AK2 variants implicated in early onset generalized dystonia, which can be dominantly or recessively inherited, or occur de novo. Our findings provide direct evidence for a key role of a dysfunctional eIF2α pathway in the pathogenesis of dystonia. ANN NEUROL 2021;89:485–497.</p

MEG Can Map Short and Long-Term Changes in Brain Activity following Deep Brain Stimulation for Chronic Pain

Deep brain stimulation (DBS) has been shown to be clinically effective for some forms of treatment-resistant chronic pain, but the precise mechanisms of action are not well understood. Here, we present an analysis of magnetoencephalography (MEG) data from a patient with whole-body chronic pain, in order to investigate changes in neural activity induced by DBS for pain relief over both short- and long-term. This patient is one of the few cases treated using DBS of the anterior cingulate cortex (ACC). We demonstrate that a novel method, null-beamforming, can be used to localise accurately brain activity despite the artefacts caused by the presence of DBS electrodes and stimulus pulses. The accuracy of our source localisation was verified by correlating the predicted DBS electrode positions with their actual positions. Using this beamforming method, we examined changes in whole-brain activity comparing pain relief achieved with deep brain stimulation (DBS ON) and compared with pain experienced with no stimulation (DBS OFF). We found significant changes in activity in pain-related regions including the pre-supplementary motor area, brainstem (periaqueductal gray) and dissociable parts of caudal and rostral ACC. In particular, when the patient reported experiencing pain, there was increased activity in different regions of ACC compared to when he experienced pain relief. We were also able to demonstrate long-term functional brain changes as a result of continuous DBS over one year, leading to specific changes in the activity in dissociable regions of caudal and rostral ACC. These results broaden our understanding of the underlying mechanisms of DBS in the human brain