46 research outputs found
Synthesis of HydrogenâBond Surrogate αâHelices as Inhibitors of ProteinâProtein Interactions
An inhibitory mechanism of action of coiledâcoil peptides against type three secretion system from enteropathogenic Escherichia coli
Activity of antimicrobial peptides, alone or combined with conventional antibiotics, against Staphylococcus aureus
PolymerâDoxorubicin Conjugate with a Synthetic Peptide Ligand Targeted on Prostate Tumor
Toward the development of prophylactic and therapeutic human papillomavirus type-16 lipopeptide vaccines
Four lipid-core peptide systems were synthesized using stepwise solid-phase peptide synthesis, incorporating a sequence from the human papillomavirus type-16 (HPV-16) E7 protein (E7(44-62)), for the purpose of developing vaccines against HPV-16 associated cervical cancer. D-Mannose was conjugated to the vaccine in order to investigate whether the targeting of dendritic cell mannose receptors would improve vaccine efficacy. The ability of the vaccines to clear or reduce the size of HPV-16 associated tumors was assessed in C57BL/6 (H-2(b)) mice using the TC-1 HPV-16 tumor model. Overall, significant reductions in the size of TC-1 tumors were observed in the mouse model, with the conjugation of mannose to these vaccines demonstrated to clear or reduce the size of TC-1 tumors to a greater extent than non-mannose-containing vaccines (37 out of 40 versus 21 out of 30 tumors cleared, respectively)