5 research outputs found
Predicting the Development of Anti-Drug Antibodies against Recombinant alpha-Galactosidase A in Male Patients with Classical Fabry Disease
- Author
- Publication venue
- Publication date
- 12/08/2020
- Field of study
Fabry Disease (FD) is a rare, X-linked, lysosomal storage disease that mainly causes renal, cardiac and cerebral complications. Enzyme replacement therapy (ERT) with recombinant alpha-galactosidase A is available, but approximately 50% of male patients with classical FD develop inhibiting anti-drug antibodies (iADAs) that lead to reduced biochemical responses and an accelerated loss of renal function. Once immunization has occurred, iADAs tend to persist and tolerization is hard to achieve. Here we developed a pre-treatment prediction model for iADA development in FD using existing data from 120 classical male FD patients from three European centers, treated with ERT. We found that nonsense and frameshift mutations in the α-galactosidase A gene (p = 0.05), higher plasma lysoGb3 at baseline (p < 0.001) and agalsidase beta as first treatment (p = 0.006) were significantly associated with iADA development. Prediction performance of a Random Forest model, using multiple variables (AUC-ROC: 0.77) was compared to a logistic regression (LR) model using the three significantly associated variables (AUC-ROC: 0.77). The LR model can be used to determine iADA risk in individual FD patients prior to treatment initiation. This helps to determine in which patients adjusted treatment and/or immunomodulatory regimes may be considered to minimize iADA development risk. View Full-Tex
Identifying disease trajectories with predicate information from a knowledge graph
- Author
- A Collins
- A Giannoula
- A Venkataraman
- AB Jensen
- AL Barabási
- AP Bradley
- B Smith
- B Smith
- B Titz
- C Hidalgo-Tenorio
- C Wheatley
- DS Himmelstein
- E Antezana
- EG Cerami
- EM de Freitas
- EX Wei
- G Bebek
- G Faraco
- GK Il
- GP Jordaan
- H Chen
- H Kilicoglu
- H Kilicoglu
- HX Li
- IH Lok
- J Li
- J Menche
- J Piñero
- J Spence
- JA Luchsinger
- JD Hunter
- JM Pego-Reigosa
- K Sun
- K Yi
- KJ Li
- LI Furlong
- LJA Toonen
- M Kuhn
- M van den Akker
- MD Wilkinson
- MG Kann
- MJ Berridge
- MN Haan
- MN Wright
- PI Kontou
- RC Kiefer
- S Aymé
- S Bang
- T Kamradt
- TA Lasko
- TB Malas
- VSE Jeganathan
- WJ Vlietstra
- WJ Youden
- X Robin
- Y Li
- YH Chen
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Using predicate and provenance information from a knowledge graph for drug efficacy screening
- Author
- AB Jensen
- AP Bento
- AP Bradley
- C Mitsopoulos
- D Croft
- D Weissenborn
- DF Wolfgram
- DS Himmelstein
- E Guney
- E Guney
- F Heinemann
- F Jordán
- F Macheret
- H Chen
- H Kilicoglu
- H Lee
- HL Banh
- J Grau
- J Menche
- J Piñero
- J Xu
- JL Auger
- JM Fry
- K Azzaoui
- K Dalleau
- KN Ekdahl
- M Fernández-Delgado
- M Hofmann-Apitius
- M Kuhn
- MA Sartor
- MG Kann
- N Principi
- R Santos
- RA Hodos
- S Berman
- S Daminelli
- TF Kelly
- TI Morgenthaler
- V Bernier
- W Wang
- WJ Vlietstra
- WQ Wei
- X Robin
- Y Liu
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Valsartan Cardio-Renal Protection in Patients Undergoing Coronary Angiography Complicated With Chronic Renal Insufficiency (VAL-CARP) Trial
- Author
- Barrett BJ Parfrey PS, Vavasour HM
- Bloch MJ Basile J
- Cockroft D Gault M
- Cohn JN Tognoni G, the Valsartan H
- Conlon PJ Athirakul K, Kovalik E,
- Conlon PJ Stafford-Smith M, White
- Davidson CJ Hlatky M, Morris KG, P
- Hiromichi Suzuki
- Imamura H Izawa A, Kai R, Yokoseki
- Jean WJ al-Bitar I, Zwicke DL, Por
- Kazuo Matsumoto
- Levey AS Coresh J, Balk E, Kausz A
- Moore RD Steinberg EP, Powe NR, Br
- Naofumi Ikeda
- Nobuyuki Komiyama
- Pinkau T Mann JF, Ndrepepa G, Mehi
- Rossing K Christensen PK, Jensen B
- Rossing K Jacobsen P, Pietraszek L
- Rudnick MR Berns JS, Cohen JJ, Gol
- Ruilope L Aldigier J, Ponticelli C
- Shigeyuki Nishimura
- Shunei Kyo
- Solomon R
- Solomon R Werner C, Mann D, D
- Taliercio CP Vlietstra RE, Ilstrup
- Tsutomu Inoue
- Wang Y Ho DS, Chen WH, Wang YQ, La
- Waybill MM Waybill PN
- Weisberg LS Kurnik PB, Kurnik BRC
- Publication venue
- 'Japanese Circulation Society'
- Publication date
- 01/01/2006
- Field of study
Über die (aseptische) Harnstauungsniere
- Author
- A Adler-Ràcz von
- A Akerlund
- A Androulakakis
- A Androulakakis
- A Angelov
- A Babies
- A Babies
- A Barella
- A Batzenschlager
- A Berndorfer
- A Binz
- A Boone
- A Bouteau
- A Brenner
- A Christensen
- A Dufour
- A Döderlein
- A Feustel
- A Fritjofsson
- A Fritjofsson
- A Fränkel
- A Gabriele
- A Gaca
- A Gaca
- A Gaca
- A Gaca
- A Gentile
- A Giordano
- A Grunberg
- A Guetgemann
- A Guichard
- A Hagen
- A Hauge
- A Hauge
- A Homb
- A Hottinger
- A Illich
- A Israel
- A Kalo
- A Kohn
- A Kuntz
- A Lakos
- A Lardelli
- A Levievre
- A Lhez
- A Lichtenberg
- A Lichtenberg
- A Lisnell
- A Litwak
- A Ljungqvist
- A MacKellar
- A Martinez-Pineiro
- A Megevand
- A Napolitano
- A Paalanen
- A Paalanen
- A Paalanen
- A Pasqualino
- A Pena De la
- A Pena De la
- A Pena De la
- A Pichler
- A Pieper
- A Pieper
- A Pozzan
- A Randall
- A Rossier
- A Rothschild
- A Sadi
- A Sadi
- A Sadi
- A Saint-Aubert
- A Schabadasch
- A Schimatzek
- A Schwyzer
- A Sigel
- A Sigel
- A Sigel
- A Sigel
- A Surtshin
- A Szkodny
- A Theilhaber
- A Theilhaber
- A Thelen
- A Thelen
- A Thelen
- A Thiemann
- A Tormene
- A Trabucco
- A Tzank
- A Villanueva
- A Weicheisbaum
- A Wojewski
- A Wojewski
- A Wolf
- A Wolotzky
- A Wöller
- A Zinner
- A-A Kollwitz
- A-O Büchner
- AB Bhajekar
- AB Cecil
- AB Cecil
- AB Novikoff
- AB Stewart
- AC Abbott
- AC Allen
- AC Bratton
- AC Burton
- AC Smid
- AC Uson
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- AD Amar
- AD Dias
- AD Merrit
- AE Brule
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- AE Cohen
- AE Comarr
- AE Melnikoff
- AE Roche
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- AH Samily
- AH Smith
- AH Ulm
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- AI Murphy
- AJ Bland
- AJ Botting
- AJ Fink
- AJ Leader
- AJ McQueeney
- AJ Paquin
- AJ Paquin
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- AJ Spriggs
- AK Doss
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- AL Dean
- AL Finkle
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- AL Hodgkin
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- AL Miller
- Alcalá-Santacella Nunez y Montesinos
- AM Behnam
- AM Hogben
- AM Lefkovits
- AM Lotfi
- AN Green
- AP Briggs
- AP Carritano
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- Evaluation of intubation ureterotomy with description of surgical technique
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- Experimental hydronephrosis without mechanical obstruction of the ureter
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- W Coppridge
- W Felix
- W Forssmann
- W Gregoir
- W Gregoir
- W Gregoir
- W Gregoir
- W Gütter
- W Heckenbach
- W Heintze
- W Henberger
- W Hinz
- W Hoffmann
- W Huth
- W Hüther
- W Kny
- W Kny
- W Kolmer
- W Kosenow
- W Lehmann
- W Lindemann
- W Lindemann
- W Lindemann
- W Lindemann
- W Lorbeck
- W Ludvik
- W Lutzeyer
- W Lutzeyer
- W Lutzeyer
- W Lutzeyer
- W Lutzeyer
- W Lutzeyer
- W Lutzeyer
- W Marquardz
- W Modelski
- W Nonnenbruch
- W Pagel
- W Pagel
- W Pagel
- W Pagel
- W Pfeifer
- W Rattner
- W Samellas
- W Samellas
- W Schega
- W Schneider
- W Selberg
- W Singh
- W Sinner
- W Sinner
- W Sinner
- W Sleator
- W Staehler
- W Staehler
- W Suter
- W Teschendorf
- W Tlnnemeyer
- W Walters
- W Walters
- W Walters
- W Weibel
- W Weibel
- W Weiner
- W Weiner
- W Weisel
- W Wirbatz
- W Wüseke
- W Zaunbauer
- W Zimmer
- WA Griesbach
- WA Moonen
- WA Moonen
- WA Moonen
- WA Pepper
- WA Roll
- WA Roll
- WB Carpenter
- WB Schwartz
- WC Bailey
- WC Casey
- WC Quinby
- WC Quinby
- WD Jarman
- WE Goodwin
- WE Goodwin
- WE Goodwin
- WE Goodwin
- WE Lado
- WF Braasch
- WF Braasch
- WF Braasch
- WF Braasch
- WF Katzenstein
- WF Melick
- WF Melick
- WF Melick
- WFW Southwood
- WH Brinkmann
- WH Falor
- WH Howell
- WJ Baker
- WJ Engel
- WJ Forsythe
- WJ Forsythe
- WJ Israel
- WJ Rapp
- WJ Rapp
- WL Fitzgerald
- WM Bayliss
- WM Bochove van
- WM Davidson
- WM Drake
- WM Perelman
- WP Mulvaney
- WR McCune
- WR Schmalhorst
- WR Smart
- WS Kerr
- WS Kerr
- WS Kerr
- WS Mack
- WT Hunter
- WT Snodgrass
- WW Davey
- WW Milner
- WW Scott
- WW Summerville
- WW Woodward
- Y Fumio
- Y Kitani
- Y Lazebnik
- Y Satani
- Y Suzuki
- YG Miterev
- YJ Katz
- Z Kairis
- Z Kairis
- Z Kairis
- Z Kairis
- Z Nagy
- Z Piasecki
- ZHJ Vuurst Van Der
- Zur Behandlung postoperativer bzw. posttraumatischer Harnleiterfibrosen
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1968
- Field of study