1 research outputs found
Interaction of HostâMicrobial Metabolism in Sepsis
The majority of species of the human gut microbiota is not cultivated on artificial nutrient media, but they are included in the functioning of microbial metabolic conveyor. Between the numerous gut bacteria (transmitter) and billions of intracellular mitochondria (receiver), the function of signaling molecules performs aromatic metabolites. Sepsis destroys the coordinated work of the indigenous anaerobic microflora. This leads to the imbalance of aromatic microbial metabolites (AMM). We hypothesized and proved diagnostic and pathogenic significance of this. First, deficiency of the end products of microbial metabolismâlipophilic AMM (PhPA and derivativesâcinnamic and benzoic acids) in sepsis, and second, excessive accumulation in blood of intermediate products named, âsepsisâassociatedâ AMMâboth lead to the development of mitochondrial dysfunction. Particularly, the total suppressed production of mROS can manifest by âhibernateâlike stateâ of cells and lead to MOF. The participation of aromatic metabolites in the development of septic shock can be explained by the inhibition of tyrosine hydroxylase and impaired synthesis of catecholamines. In clinical research, the high levels of âsepsisâassociatedâ AMM (pâHPhAA, pâHPhLA, and PhLA) correlate with the severity according to APACHE II, Sepsis-related Organ Failure Assessments (SOFA) score and mortality. To improve the survival of ICU patients, requires more attention to the role of imbalance of microbial metabolites in sepsis