Assessing the effects of underground mining activities on high-voltage overhead power lines

This paper introduces a technique for predictive assessment of changes in the position of power transmission towers and condition of overhead power lines, located in the zone of influence of displacements and deformations of the Earth's surface caused by mining activities. A special approach for monitoring the technical condition of towers and cables is proposed. It is intended to address the issue of controlling the condition of transmission lines that are under the influence of underground mining activities and to checkmate such impact

Improving Approaches to Strategic Enterprise Management in the Context of Sustainable Development

This article discusses the issues of improving strategic management of sustainable development of enterprises of the Russian Federation. The management of many companies continues to demonstrate an inadequate attitude to the development and implementation of a system of measures to ensure the proper level of sustainability of an industrial company. The main problem considered in the study is the insufficiently perfect mechanism for the strategic management of the investment policy of industrial enterprises in the Ural region of Russia. The management of many enterprises does not conduct a comprehensive assessment of sustainability and does not rely on the triad of sustainable development indicators—economic, environmental, and social. This negatively affects the strategic management decisions made. Under an insufficiently perfect mechanism, in this study, we refer to the following: At Russian regional enterprises, there is no close connection between the processes of making strategic decisions and the investment policy of the enterprise. This leads to certain errors in the formation of the enterprise strategy. The connecting element of these processes is highlighted. It is a comprehensive assessment of sustainability. The main objective of this study is to improve the model and mechanism of strategic management of the investment policy of the enterprise in the context of the environmental and economic status of the business. The proposed model is based on the principles considered from the perspective of three directions—economic, social, and environmental. This model provides for a close interconnection of components: management decision-making, investment policy development, and comprehensive assessment of sustainable development strategy. Based on the analysis of scientific works, the practice of managing industrial enterprises and certain gaps have been identified in theoretical sources related to the topic, problem, and objectives of the article. The methodological base of the study is determined, and methodological aspects of the analysis of the ecological state of business projects and the formation of strategic management of investment activity of an industrial enterprise are substantiated. The model for managing sustainable enterprise development is presented. This model provides for close interaction between the mechanisms for developing strategic decisions and managing the investment policy of the enterprise based on the environmental component of the business as a factor in sustainable development. Tools are proposed that ensure interconnection and synergy between the components of strategic management of the investment policy of the company and improve the quality of management decisions

Assessing the effects of underground mining activities on high-voltage overhead power lines

This paper introduces a technique for predictive assessment of changes in the position of power transmission towers and condition of overhead power lines, located in the zone of influence of displacements and deformations of the Earth's surface caused by mining activities. A special approach for monitoring the technical condition of towers and cables is proposed. It is intended to address the issue of controlling the condition of transmission lines that are under the influence of underground mining activities and to checkmate such impact

Assessing the effects of underground mining activities on high-voltage overhead power lines

This paper introduces a technique for predictive assessment of changes in the position of power transmission towers and condition of overhead power lines, located in the zone of influence of displacements and deformations of the Earth's surface caused by mining activities. A special approach for monitoring the technical condition of towers and cables is proposed. It is intended to address the issue of controlling the condition of transmission lines that are under the influence of underground mining activities and to checkmate such impact

Strategic Aspects of Ensuring Sustainable Development of Gold Enterprises of the Russian Federation

This article focuses on the sustainable, equilibrium development of Russian enterprises engaged in the extraction and processing of gold. The conditions for the effective activity of companies in the field of gold mining were considered. The main factors causing crisis situations and problems in the strategic management of gold mining enterprises of the Russian Federation were highlighted. The main objective of the study was to develop proposals for improving the model and mechanism of the strategic management of the gold mining company. The study analyzed a wide range of theoretical sources, identified gaps in scientific works in contact with the topic of this work. These gaps were associated primarily with the inadequate reflection in the existing models of industrial enterprise management of the specifics of the activities of gold companies and the lack of key components of the model, affecting sustainable business development. The methodological basis of the study was: Systems theory and systems approach, economic and mathematical models of firm management, investment design, theoretical studies in the field of business valuation. In connection with the growing risks, socio-economic instability, the fall in the growth rate of gold mining, the problems presented in the study are relevant. Maintaining competitiveness and improving performance indicators requires the improvement of the process of the strategic management of mining companies. This article discusses the fundamental components of an improved model of strategic management of gold mining enterprises proposed by the authors, presents a graphical model, suggests directions for describing an improved management mechanism for a gold mining company using mathematical modeling methods designed to link the most problematic components and gold mining business processes: investment, technology intelligence and gold mining, capital investment, timing of the project Comrade, the profitability of production. The dynamic simulation model of strategic management presented in this study and strategy assessment tools based on the concept of the organization’s life cycle take into account the specifics of the activities of gold companies in Russia; were introduced into the practice of the enterprises of Siberia, Sakha-Yakutia, which led to increased economic sustainability and improved financial performance of these companies

Improving the Strategic Management of Investment Activities of Industrial Enterprises as a Factor for Sustainable Development in a Crisis

This article discusses the problem of improving the strategic management of sustainable development in industrial enterprises in Russia. The shortcomings of the strategic management of industrial enterprises are due to the fall in the growth rates of the world and domestic economy, international sanctions, and the specifics of the development of socio-economic relations in the Russian Federation. The main problem of the research is related to the imperfection of the strategic management of the investment policy of the enterprise, which leads to a slowdown in the development of the company and a decrease in competitiveness. The main goal of the presented research is to develop proposals for improving the strategic management model for the development and implementation of investment strategies of an industrial enterprise. Based on the analysis of theoretical sources, gaps in research related to the topic and objectives of this work are highlighted. The methodological base of the research is determined, the basis of which are: system theory, systematic approach to managing a company’s sustainable development, theory and practice of modeling, strategic management, investment design. The improved model is proposed, which determines the interdependence of the strategic management of investment policy and the sustainable economic development of the company, presents the algorithm for managing the process of developing investment strategies in an industrial enterprise. This mechanism takes into account the main indicators of sustainable development of an industrial enterprise. There are proposals to improve the management model of insurance reserves of the company, reflecting the strategic aspects of investment activities necessary for the successful implementation of the course on sustainable development in an industrial company. The obtained results were tested by a number of Russian enterprises, which led to positive results of their activities, contributed to more sustainable development and strengthening of competitive positions

Antibodies raised against a Sunn bug (Eurygaster integriceps Put.) recombinant protease, rGHP3p2, can inhibit gluten-hydrolyzing activity

Sunn pest or Sunn bug, Eurygaster integriceps Put., salivary gland proteases are responsible for the deterioration of wheat flour quality during dough mixing, resulting from gluten hydrolysis. These proteases are highly heterogeneous and show low sensitivity to most types of proteinaceous inhibitors, meaning that such inhibitors cannot be used to prevent gluten damage. The present study describes the generation of a specific peptide antibody, raised against the active center of the recombinant gluten-hydrolyzing protease (GHP3). The recombinant protein, encoding two repeats of the GHP3 sequence element involved in forming the S4 pocket and binding of substrate at position P4, was designed and expressed in Escherichia coli. The antibodies raised to this recombinant protein showed inhibitory activity against the GHP3 protease. The results indicate that it is possible to design specific antibodies to inhibit wheat-bug gluten-hydrolyzing proteases

Construction of scFv Antibodies against the Outer Loops of the Microsporidium <i>Nosema bombycis</i> ATP/ADP-Transporters and Selection of the Fragment Efficiently Inhibiting Parasite Growth

Traditional sanitation practices remain the main strategy for controlling Bombyx mori infections caused by microsporidia Nosema bombycis. This actualizes the development of new approaches to increase the silkworm resistance to this parasite. Here, we constructed a mouse scFv library against the outer loops of N. bombycis ATP/ADP carriers and selected nine scFv fragments to the transporter, highly expressed in the early stages of the parasite intracellular growth. Expression of selected scFv genes in Sf9 cells, their infection with different ratios of microsporidia spores per insect cell, qPCR analysis of N. bombycis PTP2 and Spodoptera frugiperda COXI transcripts in 100 infected cultures made it possible to select the scFv fragment most effectively inhibiting the parasite growth. Western blot analysis of 42 infected cultures with Abs against the parasite β-tubulin confirmed its inhibitory efficiency. Since the VL part of this scFv fragment was identified as a human IgG domain retained from the pSEX81 phagemid during library construction, its VH sequence should be a key antigen-recognizing determinant. Along with the further selection of new recombinant Abs, this suggests the searching for its natural mouse VL domain or “camelization” of the VH fragment by introducing cysteine and hydrophilic residues, as well as the randomization of its CDRs