MONOCLONAL ANTIBODIES AGAINST MAN'S IMMUNOGLOBULINES

On base of the new strain of the mice myeloma cells and immunic lymphocytes of the SJL/J line mice the monoclonal antibodies (MCAB) against the types, basic isotypes and subisotypes lg of the man have been created. As a result of studying epitopic specifity and serological activity of MCAB and separation of the reagents answering to a number of the criteria the panel providing the quantitative determination of the free light chains, lg cappa- and lambda-types, basic isotypes and sub-isotypes and also investigation of the isotypical spectra in the antibodies directed against the infections agents, allergens and autoantigens has been formed. A possibility to apply MCAB in the test-systems for diagnosis of the infectious, allergic, autoimmunic diseases, malignant and benign gammapathies has been determined.Available from VNTIC / VNTIC - Scientific & Technical Information Centre of RussiaSIGLERURussian Federatio