Problems for elliptic singular equations with a quadratic gradient term

AbstractWe investigate the homogeneous Dirichlet problem for a class of second-order elliptic partial differential equations with a quadratic gradient term and singular data. In particular, we study the asymptotic behaviour of the solution near the boundary under suitable assumptions on the growth of the coefficients of the equation

Tra Salerno e Terra di Bari. Per la storia del notariato nel Mezzogiorno medievale

Notaries contributed to the consolidation of the public institutions of the Norman-Swabian Kingdom of Sicily thanks to their employment in the central and provincial administration, while continuing mostly to operate at the service of private customers. The progress made in terms of editorial practices by the notaries in some of the most dynamic cities of Campania and Puglia also gave rise to the connection with the royal curia, in order to respond to the needs of a growing society on an economic and social levels. In the 14th-15th centuries they also played an important role in the development of trading activities, adopting new types of documents and commercial contracts.I notai contribuirono fin dall'inizio al consolidamento delle istituzioni pubbliche del Regno normanno-svevo di Sicilia grazie al loro impiego nell'amministrazione centrale e provinciale, pur continuando per lo più ad operare al servizio della loro clientela privata. All'origine del collegamento con la curia regia si posero anche i progressi realizzati sul piano delle prassi redazionali dai notai di alcune delle città più dinamiche di Campania e Puglia, per rispondere alle esigenze di una società in crescita sul piano economico e sociale. Nei secoli XIV-XV svolsero un ruolo importante anche per lo sviluppo dei commerci, adottando nuove tipologie di documenti e di contratti notarili.&nbsp

Validation of a small scale woody biomass downdraft gasification plant coupled with gas engine

In recent years, small scale cogeneration systems (< 500 kWe) distributed in different geographical locations using biomass has received special attention as economically competitive and environmentally friendly ways of producing energy. These systems can be integrated to industrial and agricultural activities where biomass residues are generated and can be converted into electricity and thermal energy by combustion or gasification. The legislations of many European countries such as Italy concerning renewable energy and energy efficiency along the taxation schemes have raised the incentives for small scale cogeneration plants. Consequently, there is a clear economic interest of the companies in this sector and there is also a scientific interest towards demonstration of their energetic efficiency, environmental performance and reliability. Among the suggested technologies for the biomass conversion into energy, downdraft gasification (using air as gasification agent), coupled with internal combustion engines, has the advantage of high electric efficiency (~ 25%) and low tar generation, making easier the gas cleaning process necessary for its use into engines. In the present work, the results of a measurement campaign performed on a commercial scale 350 kWth downdraft woodchips gasification plant, coupled with an SI internal combustion engine (ICE), are presented and discussed. The main goals of this first experimental campaign have been to verify the stability of gasifier and engine operation, operability of the plant and to determine its energy efficiency. The campaign verified a stable operation of the gasifier and the plant produced a syngas with a composition suitable for a gas engine. The energy balance resulted in a potential overall wood fuel to electricity efficiency of about 23 %

On-board centralized system tor regulating the pressure of the tyres of a motor-vehicle

An on-board centralized system for regulating the pressure of the tyres of a motor-vehicle. Tue system comprises a source of pressurized air (lOl), two toroidal pneumatic rotary joints (T) each associated to a driving wheel (W) ofthe motor-vehicle, and a circuit that sets in communication the source of pressurized air (I O l) with an inlet fitting of each pneumatic rotary joint (T). Tue output member of the constant-velocity joint (J) and the wheel spindle (7) have an internal duct (65) for passage of air, connected on one side to the respective pneumatic rotary joint (T) and on the other side to a plenum (P) of the respective driving wheel (W). Each non-driving wheel (WR) has its wheel spindle ( 46) traversed by an axial bare for the passage of air, connected on one side to the air-supply circuit via a pneumatic rotary joint (TR) and on the other side to a plenum (PR) of the non-driving wheel (WR), which is in turn connected to the inner chamber (C) of the tyre. Each driving wheel or non-driving wheel has its plenum (P, PR) connected to the inner chamber (C) of the tyre via two parallel lines (L2, L3), for deflating and inflating, respectively, the tyre interposed in which are respective one-way valves (28, 32). Tue one-way valve (28) on the deflation line is provided with a return spring (30), which guarantees a pre-set minimum value of he pressure of the inner chamber (C) of the tyre

Comfort Driven Redesign: The Case of Library Chairs

AbstractUniversity students spend most of their time in a sitting position. Prolonged sitting on ill-fitted furniture and the resulting lousy posture is making students having different musculoskeletal disorders and is strictly related to students learning outcomes. This study aims to improve postural comfort of chairs placed inside the Science & Technology Library at the University of Salerno. A previous study about these library chairs showed that the lumbar area was the most suffering part while perceived (dis)comfort was dependent on time. Based on this, an ergonomic redesign and, consequently, manufacturing of the chair has been done. A perceived-comfort comparison between the library chair and the redesigned one has been performed. A statistical sample of 28 healthy students performed a 20-min experiment two times, alternatively on the library chair and the redesigned one. The 20-min experiment was divided into two 10-min tasks ("Reading & Writing" and "Laptop use") to simulate a study day. The participants' postures were acquired non-invasively using cameras and processed by Kinovea; questionnaires were used to rate the perceived subjective (dis)comfort. A procedure for improving an existing product through a comfort-driven redesign is proposed. Results showed the redesigned library chair lead on increasing postural comfort (particularly in the lumbar area) thanks to the new design and modifications

Non Monotonous Effects of Noncovalently Functionalized Graphene Addition on the Structure and Sound Absorption Properties of Polyvinylpyrrolidone (1300 kDa) Electrospun Mats

Graphene is an attractive component for high-performance stimuli-responsive or 'smart' materials, shape memory materials, photomechanical actuators, piezoelectric materials and flexible strain sensors. Nanocomposite fibres were produced by electrospinning high molecular weight Polyvinylpyrrolidone (PVP-1300 kDa) in the presence of noncovalently functionalised graphene obtained through tip sonication of graphite alcoholic suspensions in the presence of PVP (10 kDa). Bending instability of electrospun jet appears to progressively increase at low graphene concentrations with the result of greater fibre stretching that leads to lower fibre diameter and possibly conformational changes of PVP. Further increase of graphene content seams having the opposite effect leading to greater fibre diameter and Raman spectra similar to the pure PVP electrospun mats. All this has been interpreted on the basis of currently accepted model for bending instability of electrospun jets. The graphene addition does not lower the very high sound absorption coefficient, α, close to unity, of the electrospun PVP mats in the frequency range 200⁻800 Hz. The graphene addition affects, in a non-monotonous manner, the bell shaped curves of α versus frequency curves becoming sharper and moving to higher frequency at the lower graphene addition. The opposite is observed when the graphene content is further increased

Potential involvement of IL-9 and Th9 cells in the pathogenesis of rheumatoid arthritis

Objective. IL-9 has been shown to be upregulated before the clinical onset of articular disease in RA. The exact role of IL-9 and Th9 cells in RA, however, has not yet been adequately studied. The aim of this study was to evaluate the expression of IL-9 and IL-9-expressing cells in RA patients. Methods. IL-9, IL-9R, PU.1, IL-9, thymic stromal lymphopoietin (TSLP), IL-4 and TGF-β expression was assessed by real-time-PCR in the synovial tissues of RA and OA patients. IL-9, IL-9R, IL-4, TSLP and TGF-β were also investigated by immunohistochemistry. Peripheral CD4+ T cell subsets were studied by flow cytometry analysis before and after incubation with citrullinated peptides. Results. IL-9 was overexpressed in RA synovial tissues and correlated with the degree of histological organization of B and T cells in ectopic lymphoid structures. The majority of IL-9-producing cells were identified as CD3+ cells. Increased mRNA and protein expression of IL-9R, IL-4, TSLP and TGF-β was also observed in RA synovial tissue. Blood peripheral Th9 cells were expanded by citrullinated peptides. Conclusion. These results indicate that Th9 cells and IL-9 were frequently detected in peripheral blood mononuclear cells and synovia of RA patients. A possible pathogenic role for Th9 in RA is discussed

Long-Term Results of the FOLL05 Trial Comparing R-CVP Versus R-CHOP Versus R-FM for the Initial Treatment of Patients With Advanced-Stage Symptomatic Follicular Lymphoma

Purpose The FOLL05 trial compared R-CVP (rituximab plus cyclophosphamide, vincristine, and prednisone) with R-CHOP (rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone) and R-FM (rituximab plus fludarabine and mitoxantrone) regimens without rituximab maintenance as initial therapy for patients with advanced-stage follicular lymphoma (FL). A previous analysis with a median follow-up of 34 months showed a superior 3-year time to treatment failure, the primary study end point, with R-CHOP and R-FM versus R-CVP and showed R-CHOP to have a better risk-benefit ratio in terms of toxicity than R-FM. We report a post hoc analysis of this trial after a median follow-up of 7 years. Patients and Methods Of the 534 enrolled patients, 504 were evaluable. At the time of analysis, the median follow-up was 84 months (range, 1 to 119 months). Results The 8-year time to treatment failure and progression-free survival rates were 44% (95% CI, 39% to 49%) and 48% (95% CI, 43% to 53%), respectively. The hazard ratio for progression-free survival adjusted by FL International Prognostic Index 2 versus R-CVP was 0.73 for R-CHOP (95% CI, 0.54 to 0.98; P = .037) and 0.67 for R-FM (95% CI, 0.50 to 0.91; P = .009). The 8-year overall survival (OS) rate was 83% (95% CI, 79% to 87%), with no significant differences among study arms. Overall, we observed a higher risk of dying as a result of causes unrelated to lymphoma progression with R-FM versus R-CVP. Conclusion With an 83% 8-year OS rate, long-term follow-up of the FOLL05 trial confirms the favorable outcome of patients with advanced-stage FL treated with immunochemotherapy. The three study arms had similar OS but different activity and toxicity profiles. Patients initially treated with R-CVP had a higher risk of lymphoma progression compared with those receiving R-CHOP, as well as a higher risk of requiring additional therapy

The ribosomal P0 protein induces a spontaneous immune response in patients with head and neck advanced stage carcinoma that is not dependent on its overexpression in carcinomas

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