23 research outputs found
The Bis(1,2,3,4-tetrahydroisoquinoline) Alkaloids Cepharanthine and Berbamine Are Ligands of SK Channels
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The gating pore blocker 1-(2,4-xylyl)guanidinium selectively inhibits pacemaking of midbrain dopaminergic neurons
Full text linkDéveloppement de nouveaux dérivés d'un alcaloïde naturel, la Crispine E, comme bloqueurs de canaux SK
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De nouveaux outils pharmacoogiques pour les canaux SK
Full text linkSK channels are interesting targets for depression and several pathological conditions. Current tools are not good enough to be used in therapy. Here, we present a chemistry program aiming to design new SK blockers with better characteristics that could lead to innovative treatment options.A new pharmacophore for better SK tool
Deciphering the molecular mechanism of SK2 channel activation by intracellular calcium to develop new therapeutic agents
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CEPHARANTHINE AND BERBAMINE HAVE A SIGNIFICANT AFFINITY FOR THE SMALL CONDUCTANCE Ca 2+ - ACTIVATED K+ CHANNELS.
Full text linkLes analogues benzhydrols de bis-isoquinoliniums : des entités chirales avec le potentiel d'interagir avec les canaux SK
Full text linkSK channels are appealing targets but need better pharmacological tools. Here, we present a work highlighting a new synthesis pathway for bis-quinolinium blockers allowing for further extension and evaluationg the chiral aspect of target interaction with SK channelsA new pharmacophore for better SK tool
