4 research outputs found
Deciphering the quality of SARS-CoV-2 specific T-cell response associated with disease severity, immune memory and heterologous response
SARS-CoV-2 specific T-cell response has been associated with disease severity, immune memory and heterologous response to endemic coronaviruses. However, an integrative approach combining a comprehensive analysis of the quality of SARS-CoV-2 specific T-cell response with antibody levels in these three scenarios is needed. In the present study, we found that, in acute infection, while mild disease was associated with high T-cell polyfunctionality biased to IL-2 production and inversely correlated with anti-S IgG levels, combinations only including IFN-Îł with the absence of perforin production predominated in severe disease. Seven months after infection, both non-hospitalised and previously hospitalised patients presented robust anti-S IgG levels and SARS-CoV-2 specific T-cell response. In addition, only previously hospitalised patients showed a T-cell exhaustion profile. Finally, combinations including IL-2 in response to S protein of endemic coronaviruses were the ones associated with SARS-CoV-2 S-specific T-cell response in pre-COVID-19 healthy donorsâ samples. These results could have implications for protective immunity against SARS-CoV-2 and recurrent COVID-19 and may help for the design of new prototypes and boosting vaccine strategies
Immune defects associated with lower SARS-CoV-2 BNT162b2 mRNA vaccine response in aged people
The immune factors associated with impaired SARS-CoV-2 vaccine response in elderly people are
mostly unknown. We studied individuals older than 60 and younger than 60 years, who had been
vaccinated with SARS-CoV-2 BNT162b2 mRNA, before and after the first and second dose. Aging
was associated with a lower antiâRBD IgG levels and a decreased magnitude and polyfunctionality
of SARS-CoV-2âspecific T cell response. The dramatic decrease in thymic function in people >
60 years, which fueled alteration in T cell homeostasis, and their lower CD161+
T cell levels were
associated with decreased T cell response 2 months after vaccination. Additionally, deficient DC
homing, activation, and TLR-mediated function, along with a proinflammatory functional profile
in monocytes, were observed in the > 60-year-old group, which was also related to lower specific T
cell response after vaccination. These findings might be relevant for the improvement of the current
vaccination strategies and for the development of new vaccine prototypes.Junta de AndalucĂ
HERC1 IS NECESSARY FOR AUTOPHAGY PROCESSES AND FOR THE MAINTENANCE AND HOMEOSTASIS OF VESICLES IN THE NEUROMUSCULAR JUNCTION, BUT NOT FOR THE PROTEASOMAL ACTIVITY.
A metagenome-wide association study of HIV disease progression in HIV controllers
Summary: Some HIV controllers experience immunologic progression with CD4+ T cell decline. We aimed to identify genetic factors associated with CD4+ T cell lost in HIV controllers. A total of 561 HIV controllers were included, 442 and 119 from the International HIV controllers Study Cohort and the Swiss HIV Cohort Study, respectively. No SNP or gene was associated with the long-term non-progressor HIV spontaneous control phenotype in the individual GWAS or in the meta-analysis. However, SNPs previously associated with natural HIV control linked to HLA-B (rs2395029 [p = 0.005; OR = 1.70], rs59440261 [p = 0.003; OR = 1.78]), MICA (rs112243036 [p = 0.011; OR = 1.45]), and PSORS1C1 loci (rs3815087 [p = 0.017; OR = 1.39]) showed nominal association with this phenotype. Genetic factors associated with the long-term HIV controllers without risk of immunologic progression are those previously related to the overall HIV controller phenotype