Research of Rational Concentration of Oilseed Crops Meals in the Sandy Dough Semi-finished Product

The work studies the rational concentration of meals of soya, sunflower and milk thistle in a sandy dough semi-product for improving healthy properties of ready products (biological value, stomach peristalsis, metabolism, saturation with vitamins and mineral substances). Analytic studies were conducted and advantages of using meals in dough products were determined. The chemical composition of meals was determined, and the optimal composition for satisfying the human need that is in ratio 3:4:3 was calculated. The quality of meals was estimated, and their organoleptic parameters were analyzed. The sensor analysis of sandy semi-products of oilseed crops meals was realized. It was established, that adding of the meal composition instead of flour in amount 20 % is an optimal solution for using in a sandy dough semi-product.There was established the influence of meals of oilseed crops on organoleptic parameters of developed sandy semi-products. Advantages and defects of using the aforesaid meals were established. Ways of improving the outlook and consistence of shortcakes were offered. Ways of further studies were established

The infrastructure of public catering in the context of tourist city space development

To assess the impact of environmental factors on the activities of catering enterprises of the Belgorod region and the quality of customer service, the authors proposed a method using STEP-analysis and SWOT-analysis. The analysis of environmental factors was carried out on the basis of the expert evaluation results conducted in two stage

Transformation of museum product

Today, each museum needs to develop an active strategy of market development, which is preceded by a comprehensive analysis of potential consumers of the museum product, on the basis of which the directions of development will be proposed. The conducted research allowed us to reveal a number of problems which are connected with necessity of transformation of the museum product providing satisfaction of visitor’s requirements and, at the same time, increase in the income of the museu

Mobile technologies in implementation of programs of internal tourism development

Now a days great attention is paid to the programs of the development of domestic tourism, its informational support, the development of new tourist products. But in spite of efforts in this direction, the population of Russia still has not enough information about tourist recreational opportunities of particular regions and in the whole countr

The influence of virtual information spaces on tourism development

The desire to meet the requirements of the consumer necessitates the study of the influence of modern information and communication technologies on the development of the tourism industry by operators. The urgency of creating a virtual tourist information system, and developing its structure is required in order to match the innovative processes that involve modern technologies of Virtual and Augmented Realit

TWO-STEP MODIFICATION OF TEXTILE MATERIALS WITH MEMBRANE COATING

The possibility of using a two-stage plasma modification for improving the hygienic properties of textile materials with a membrane coating in order to improve steam, air permeability and water resistance was studied

THE BACTERICIDAL EFFECT ON SURFACES TREATED BY HIGH FREQUENCY PLASMA

A study of duration of antimicrobial properties of collagen materials treated in high frequency plasma was made. It is established that the antibacterial effect is retained for not more than two years

Прогностическое значение биологических характеристик резидуальной опухоли после проведения неоадъювантной химиотерапии при раннем раке молочной железы с тройным негативным фенотипом

Neoadjuvant chemotherapy is a widely used approach in patients with early triple-negative and Her2-positive breast cancer (BC). This allows in vivo evaluation of treatment efficacy and reduction of the local treatment extent in some patients, as well as prognosis assessment and the prescription of adjuvant chemotherapy in patients with residual tumors. The study evaluated the predictive value of estimating tumor response to treatment using the RCB (Residual Cancer Burden) staging system and assessed Ki-67 levels and tumor-infiltrating lymphocyte (TIL) concentrations in residual tumors in patients with primary operable BC with triple-negative phenotype (TN BC) receiving neoadjuvant platinum-based chemotherapy. The study revealed that complex assessment of the RCB, Ki-67, and TILs parameters provides more accurate predictive information compared to simply asserting the presence or absence of a residual tumor, and allows assignment of patients to escalation or de-escalation of adjuvant systemic therapy.Неоадъювантная (НА) лекарственная терапия широко применяется в лечении больных тройным негативным и Нег2-позитивным раком молочной железы (РМЖ) ранних стадий. Это позволяет оценить эффективность лечения in vivo, у части больных уменьшить объем локального лечения, а также оценить прогноз и при наличии резидуальной опухоли назначить адъювантную лекарственную терапию. В исследовании изучалась прогностическая значимость оценки ответа опухоли на лечение по системе RCB (Residual Cancer Burden), а также оценены уровень Ki-67 и содержание инфильтрирующих опухоль лимфоцитов (ИОЛ) в резидуальной опухоли у больных первично операбельным РМЖ с тройным негативным фенотипом (ТН РМЖ), получавших НА платиносодержащую химиотерапию (ХТ). Показано, что комплексная оценка показателей RCB, Ki-67 и ИОЛ позволяет получить более точную прогностическую информацию, чем простая констатация наличия или отсутствия резидуальной опухоли, и выделить группы больных для эскалации и де-эскалации адъювантной системной терапии

Бронхиальная астма с явлениями гипервентиляции

Eighty hospitalized bronchial asthma (BA) patients (50 females, 30 males) were divided in two groups according to hyperventilation occurrence. The average age was 45.4±1.3 years, the mean length of the illness was 9.2±1.1 years. The first group, which was the basic, involved 22 patients with the hyperventilation signs (16 females and 6 males) with the average age 44.8±1.6 years and the BA mean length 10.4±2.3 years. The second (control) group included the remained 58 patients (34 females and 24 males with the average age 47.0±2.4 years and the BA mean length 8.7±1.2 years). The mild atopic BA with a quite good course predominated in the basic group, and the severe intrinsic BA combined with chronic bronchitis prevailed in the control group. The basic group patients mostly (15 from 22) formed the hyperventilation signs within subsyndromal somatic panic attacks which started in closed stuffy rooms, or under subjectively unpleasant smells exposure, etc., were shown as dyspnoe with insignificant shortness of breath, a sense of "incomplete inspiration" accompanied by paroxysmal choking, yawning. Typically they took short time, stopped spontaneously and imitated acute bronchial obstruction symptoms, though PEF remained normal or changed less than 15% of predictive value. The searched clinical correlations could be interpreted according to a concept of congenital sensitivity of chemoreceptors (Smoller J. W. et al., 1996). The study results confirm that hyperventilation signs are basically formed in mild BA patients within the structure of the panic attacks. These data could be useful while planning therapy for such patients.В зависимости от наличия явлений гипервентиляции 80 стационарных больных бронхиальной астмой (БА) (50 женщин, 30 мужчин; средний возраст 45,4±1,3 года, средняя продолжительность заболевания 9,2±1,1 года) разделены на 2 группы. В 1-ю (основную) включены 22 пациента (16 женщин, 6 мужчин; средний возраст 44,8±1,6 года, средняя продолжительность БА 10,4±2,3 года), обнаруживающие симптомы гипервентиляции. Во 2-ю (контрольную) — оставшиеся 58 больных (34 женщины, 24 мужчины; средний возраст 47,0±2,4 года, средняя продолжительность БА 8,7±1,2 года). Для больных основной группы характерны легкая степень заболевания (в контрольной преобладает тяжелое течение БА), отличающийся сравнительно доброкачественным течением атопический вариант БА (в контрольной чаще наблюдается инфекционно-зависимый вариант БА, сочетающийся с хроническим бронхитом). В большинстве наблюдений у больных основной группы (15 из 22) симптомы гипервентиляции формируются в структуре субсиндромальных соматизированных панических атак (манифестируют в замкнутом, душном помещении, в условиях экспозиции субъективно неприятных запахов и т.д., проявляются весьма полиморфной картиной диспноэ с незначительно повышенной частотой дыхательных движений, ощущением неполноты вдоха, чувством нехватки воздуха, сопряженном с желанием "наполнить легкие кислородом", пароксизмальными поперхиванием, зевотой; как правило, кратковременны, подвергаются обратной редукции спонтанно), имитирующих симптомы острой бронхообструкции (отмечается сохранение значения PEF в пределах нормальных величин или колебание PEF менее 15% от должных показателей). Изученные клинические соотношения могут быть интерпретированы в пределах концепций врожденной чувствительности хеморецептров (Smoller J.W. и соавт ., 1996). Результаты исследования подтверждают предположения о том, что явления гипервентиляции формируются преимущественно у больных с легким течением БА в структуре панических атак. Такие данные могут быть использованы при планировании терапевтических мероприятий у изученного контингента пациентов

RESEARCH OF HYGIENIC PROPERTIES OF POROUS POLYETHYLENE FILMS WITH CaCO3

The complex of hygienic properties of polymeric polyethylene (PE) films with mineral filler СаСО3 is experimentally investigated