Predictive modelling and parametric optimization of minimum quantity lubrication assisted hobbing process

Abstract: This paper focuses on parametric analysis, modelling, and parametric optimization of minimum quantity lubrication assisted hobbing (MQLAH) using environment friendly lubricant for manufacturing superior quality spur gears. Influences of hob cutter speed, axial feed, lubricant flow rate, air pressure and nozzle angle on the deviations in total profile, total lead, total pitch and radial runout and flank surface roughness parameters were studied by conducting 46 experiments using Box-Behnken method of response surface methodology. Results revealed that effect of air pressure is negligible but other parameters have significant impact on the considered responses. Back propagation neural network (BPNN) model was developed to predict microgeometry deviations and flank surface roughness values of the MQLAH manufactured spur gears. The BPNN predicted results found to be very closely agreeing with the corresponding experimental results with mean square error as 0.0063. Real-coded genetic algorithm (RCGA) was used for parametric optimization of MQLAH process to simultaneous minimization of microgeometry deviations and flank surface roughness. Standardized values of the optimized parameters were used to conduct confirmation experiment whose results had very good closeness with RCGA computed and BPNN predicted values and produced spur gear of superior quality. This study proves MQLAH to be a potential sustainable replacement of conventional flood lubrication assisted hobbing for manufacturing cylindrical gears of better quality

Mean platelet volume as an indicator of severity of hypertensive retinopathy in hypertensive subjects

Background: Hypertensive retinopathy (HR) represents the ophthalmic findings of end-organ damage secondary to systemic arterial hypertension. Platelets play a crucial role in the pathogenesis of atherosclerotic complications, contributing to thrombus formation or apposition after plaque rupture. The aim of our study was to investigate whether Mean platelet volume (MPV) is associated with the severity of hypertensive retinopathy in hypertensive patients.Methods: This cross-sectional study was conducted in Department of Medicine of SAMC and PGI, Indore. Total 250 adult hypertensive patients (BP >140/90 mm Hg or taking antihypertensive drugs) recruited for the study.Results: Of the 250 subjects, 158 (63.2%) were male and 92 (36.8%) were female. Elevated MPV >11.5 femtoliter was observed in 84 cases (33.6%). There was statistically significant relationship between the grade of retinopathy and elevated MPV in hypertensive subjects. (r = 0.52, P <0.001).Conclusions: We described a relation between MPV and HR (probably first time in Indian patients). Measurement of MPV is easy to establish and therefore might serve as a valuable predictor of a worse outcome in microvascular complications

Elastography evaluation of normal thyroid gland and its comparison with diffuse non nodular enlarged thyroid gland using strain ultrasound elastography

Background: The thyroid gland is located in the anterior part of neck, spanning between C5 and T1 vertebra and is located anterior to the thyroid and cricoids cartilage of larynx and first three tracheal rings. Ultrasonography has been widely used for diagnosis of thyroid disease it is highly regarded for its ease of use, real-time capability, portability and low cost.Methods: The current observational study was conducted in Department of Radiology, Dr. BRAM Hospital, Pt. JNM Medical College, Raipur, India. Consecutive sampling method was used for the study. All the cases coming to radiology department during the study period were taken as study subjects.Results: Of the normal subjects, author found 107 normal thyroid subjects and 53 patients were categorized into cases with diffuse non-nodular thyroid swelling groups. Of the diffuse thyroid swelling group about 85% of the study population is between 20-50 years of age group, 13.2% were 50 years of age. Females to male ratio for diffuse thyroid disease is 3.4:1.Conclusions: Ultrasound elastography (USE) is a newly developed non-invasive method to evaluate and compare the elasticity of the thyroid gland and other organs like liver, prostate, parotid, breast pathologies. Its use is based on the principle that pathological changes in a tissue also changes its elasticity

OVERVIEW OF MITOXANTRONE-A POTENTIAL CANDIDATE FOR TREATMENT OF BREAST CANCER

Anthraquinones are one of the popular classes of aromatic compounds which possess potential anticancer properties by suppressing the nucleic acid formation and proteins essential to the survival of cancerous cells. Mitoxantrone (MT) is an antibiotic and antineoplastic agent belonging to the anthracycline class of compounds which exhibit minimal incident of drug resistance. It is a synthetic anticancer drug, bound to enzyme topoisomerase IIα inhibitor, and intercalates DNA topoisomerase IIα, preventing re-ligations in DNA strands fragmentation and disruption of DNA repair. The expression of this enzyme was used tumor cells marker because of its key function in cell proliferation. The cleavable complex of topoisomerase IIα is hypothesized to damage the DNA and may enhance apoptosis in tumor cell proliferation. The susceptibility of cells to mitoxantrone is associated with cell topoisomerase II α protein and lowered resistance in breast cancer line cell lines to topoisomerase IIα inhibitors. MT is an ABC-transporter in breast cancer, also designated to be associated with “Breast cancer resistance protein” (BCRP) and it is also a cell cycle non-specific anti-cancer drug and P-glycoprotein substrate. Multiple drug resistance is one of the major drawbacks of this drug which can be avoided by reducing the efflux of the drug from cancer cells by formulating drug by using lipophilic carriers. This manuscript discusses about MT's source, chemistry, physicochemical properties, anti-cancer effects of mitoxantrone and possible pathways, Mitoxantrone targeting topoisomerase II inhibitor for cancer therapy and its mechanism, Various Nano formulation development strategy, toxicity profile, and a few patents related information

Formulation, Development and Evaluation of Fast Dissolving Oral Film of Antidepressant Drug

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IgG4-related disease: a review with an Indian perspective

IgG4-related disease (IgG4-RD) is a recently discovered (2003) complex disease, manifesting in various organs with symptoms mimicking other diseases. Progression of the disease leads to organ failure and hence early diagnosis is an urgent requirement in these patients. There is scarcity in reporting of IgG4-RD globally and in India. The aim of the study was to generate awareness on the epidemiology, diagnosis, and practice trends for IgG4-RD in India and globally, and to aid Indian physicians in early diagnosis of IgG4-RD in patients. Additionally, the evidence currently available in the Indian subpopulation has been evaluated. A preliminary literature search was performed using the PubMed database with the keywords including ‘IgG4-related disease’ in the title and abstract to obtain the relevant data. In total, PubMed identified 2071 publications comprising world-wide studies published in the English language before 30 April 2021. Studies were filtered region-wise by adding ‘India’ to the search strategy and total 60 publications were identified. The relative newness of IgG4-RD and the ensuing paucity in literature limits diagnosis by clinicians. Awareness of the disease among Indian clinicians would improve understanding of the disease and development of a country-specific consensus-based management guideline might lead to better prognosis in Indian patients with IgG4-RD

Risk-Benefit Events Associated with the Use of Aspirin for Primary Prevention of Cardiovascular Disorders

Aspirin had been introduced as a nonsteroidal anti-inflammatory molecule. As further research on aspirin started, other therapeutic effects have been revealed. Now, this molecule has become the polychrest in medical science. Aspirin has served as a drug of choice for the primary prevention of cardiovascular disease (CVD) for the last few decades. However, recent trials have raised questions on the use of aspirin for CVD prevention due to some life-threatening adverse drug events. In spite of that, outcomes of trials will surely assist to frame a guideline for anoxic administration regimen of aspirin in order to prevent CVD

Friction Stir Process: A Comprehensive Review on Material and Methodology

In recent year, advancement of the materials and processing of the material identified as research zone to make an impact in aerospace, automobile, marine and bio-medical implants application. Improvement of the material structure and surface associated with high energy requirements as well as may contain environments harmful content, like physical and chemical vapor deposition consumes high energy and extract toxic elements. Friction stir process (FSP) is surface modification and surface composites fabrication process, which works as a solid-state process. This process based on friction between the tool and workpiece which generates heat used for modification of the material. There is no fumes generation and low energy requirement, so it comes under the domain of green technology. Customized vertical milling machine is used to perform friction stir process/welding. In this review paper, an attempt has been made to study the FSP process at a glance with brief bibliometric analysis of relevant research in last two decades. Influence of the key process parameters i.e., rotational speed, traverse speed, tool geometry and machining parameters on the microstructure and mechanical properties have also been discussed. A case study on the process parameter optimization range has been done to ensure the range of parameters. This study helps to reduce the defects during the process and improve the associated properties of the processed material. Potential difficulties and the possible measures have also been suggested for giving the future direction

What is in Name?

abstract An interesting and rare case of name syndrome is reported here. A young patient presented with stroke (left side hemiperesis due to cardiac embolic stroke) and cutaneous lesions. Further investigations revealed that left atrial myxoma was the cause of cardioembolic stroke. skin lesions were also present which included, nevi, ephelides and neurofibroma hence diagnosis of &quot;NAME sYNDROME&quot; was made