Bulk and electrochemical properties of BiVO4

The mixed (oxygen ionic-electronic) conductor bismuth vanadate (BiVO4) was studied with respect to its electrochemical properties. The ionic transference numbers, measured by the concentration cell method in the temperature range of 800 to 1000 K, vary from 0.7 to 0.3. The total conductivity of this ceramic material isone order of magnitude lower than found for cubic yttria-stabilized zirconia (YSZ). The activation enthalpy for the electronic conductivity is high (193 kJ/mol) compared to the ionic conductivity (71 kJ/mol). The PO2 dependence of the conductivity data in combination with the Seebeck measurements showed electrons to be the majority charge carriers, indicating that BiVO4 is an n-type mixed conductor

Dry mouth:saliva substitutes which adsorb and modify existing salivary condition films improve oral lubrication

OBJECTIVES: The aims of this study are to assess different saliva substitutes for their efficacy to lubricate the oral cavity, and to relate this oral lubrication to the ability of saliva substitutes to adsorb on and change the structure of the existing salivary conditioning film (SCF).MATERIALS AND METHODS: Quartz crystal microbalance with dissipation was used to study the capability of saliva substitutes to interact with natural SCF and the ability to change the secondary SCF (S-SCF). A tongue-enamel friction system mimicking xerostomic conditions was used to assess the relief and relief period expected from these substitutes under set circumstances.RESULTS: Saliva Orthana spray, Biotène spray and Gum Hydral gel had an immediate effect on a SCF, increasing its structural softness. BioXtra gel, Biotène gel, Gum Hydral gel and Glandosane spray changed the S-SCF by increasing salivary protein adsorption, while others showed no sign of interaction. With respect to relief, only 2 out of the 16 saliva substitutes tested (Saliva Orthana spray and Gum Hydral gel) performed better than water. Overall, relief period correlated positively to structural softness change, whereas a positive correlation was seen between relief and mass adsorption.CONCLUSIONS: The majority of saliva substitutes did not adsorb on the SCF, thus did not enhance lubrication. Only saliva substitutes containing carrageenan, carboxymethylcellulose, pig gastric mucin, xanthan gum and carbomer performed better in enhancing oral lubrication.CLINICAL RELEVANCE: This objective assessment will help clinicians and patients make better choice of saliva substitutes. This study provides a scientific basis for future improvement in saliva substitutes.</p

An ex vivo salivary lubrication system to mimic xerostomic conditions and to predict the lubricating properties of xerostomia relieving agents

Advances in medical research has resulted in successful treatment of many life-threatening infectious diseases as well as autoimmune and lifestyle-related diseases, increasing life-expectancy of both the developed and developing world. As a result of a growing ageing population, the focus has also turned on chronic diseases which seriously affect the quality of older patient life. Xerostomia (dry mouth) is one such condition, which leads to bad oral health and difficulty in consumption of dry foods and speech. Saliva substitutes are used to ease symptoms. However, they often don't work properly and objective comparison of saliva substitutes to mimic natural salivary functions does not exist. The study thus aims to develop an ex vivo friction assay simulating dry mouth conditions and facilitating objective comparison of saliva substitutes. A reciprocating sliding tongue-enamel system was developed and compared to a PDMS (polydimethylsiloxane)-PDMS friction system. The tongue-enamel system, but not the PDMS-PDMS model, showed high mucin-containing saliva (unstimulated and submandibular/sublingual saliva) to give higher Relief than mucin-poor lubricants (water, parotid saliva, Dentaid Xeros) and correlated well (r = 0.97) with in vivo mouth feel. The tongue-enamel friction system mimicked dry mouth conditions and relief and seems suited to test agents meant to lubricate desiccated oral surfaces

Correction to:Dry mouth: saliva substitutes which adsorb and modify existing salivary condition films improve oral lubrication

After publication of this paper, the authors observed that that figure 6 appears before figure 5

Coping with Uncertainty in River Management:Challenges and Ways Forward

Coping with uncertainties is inherent to river management planning and policymaking. Yet, policymakers often perceive uncertainty as a complicating factor. We examine the challenges faced by policymakers when coping with uncertainties and provide an action perspective on how to best cope with these challenges to inform the policy debate. Integrating social and natural scientist’s perspectives on uncertainties and learning theories, we present a holistic, management perspective for coping with uncertainty. Based on a literature review about uncertainty concepts, strategies and learning, we identify three challenges in current river management: balancing social and technical uncertainties, being conservative and avoiding to end up a lock-in situation. We then provide a step-wise strategy and concrete actions for policymakers, which are illustrated with several examples. We conclude that coping with uncertainty may require paradigm shifts that can only be achieved through organisational learning. This, we claim, requires reflection, learning and flexibility of policymakers and their organisation