26 research outputs found
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Colorimetric analysis of creatinine in whole blood and urine in a novel paper/polycaprolactone microfluidic device
A novel approach for the colorimetric detection of creatinine in a paper/polycaprolactone hybrid microfluidic device using alkaline3,5-dinitrobenzoate (DNB) is described. The reaction parameters of reagent concentration, alkalinity, and analysis time are optimized for fast reaction times and high color yield. Microfluidic devices incorporating this assay are designed and fabricated to provide a solution for low cost, point-of-care analytical applications
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Preparation, Characterization, and Structure Trends for Graphite Intercalation Compounds Containing Pyrrolidinium Cations
New graphite intercalation compounds (GICs) containing N,N-n-alkyl substituted pyrrolidinium cation intercalates (Py[subscript n.m], n, m = alkyl chain lengths) are obtained via cationic exchange from stage-1 donor-type GIC [Na(ethylenediamine)₁.₀]C₁₅. Powder X-ray diffraction and thermogravimetric analyses are used to determine the GIC structures and compositions. [Py₄.₈]C₄₇·0.71DMSO and [Py₈.₈]C₄₈ with intercalate monolayers are obtained as stage-1 GICs with gallery expansions of 0.48 nm, whereas [Py₁.₁₈]C₄₇ and [Py₁₂.₁₂]C₈₀·0.25DMSO form stage-1 GICs with intercalate bilayers and gallery expansions of 0.81 nm. The gallery dimensions require that alkyl chain substituents orient parallel to the encasing graphene sheets. Smaller intercalate cations such as Py₁.₄, Py₄.₄, and Py₁.₈ either form high-stage GICs or do not form stable intercalation compounds. These results, along with those reported for graphite intercalation of other quaternary ammonium cations, indicate trends in graphite chemistry where larger intercalates form more stable and lower-stage GICs, and the graphene sheet charge densities can be correlated to the intercalate footprint areas
Capillary Electrokinetic Chromatography (CEC): An Introduction to a High-Efficiency Microanalytical Technique
Fritless Capillary Columns for HPLC and CEC Prepared by Immobilizing the Stationary Phase in an Organic Polymer Matrix
Modeling Interparticle and Intraparticle (Perfusive) Electroosmotic Flow in Capillary Electrochromatography
Preparation and Evaluation of Bonded Linear Polymethacrylate Stationary Phases for Open Tubular Capillary Electrokinetic Chromatography
Fabrication of a Microfluidic System for Capillary Electrophoresis Using a Two-Stage Embossing Technique and Solvent Welding on Poly(methyl methacrylate) with Water as a Sacrificial Layer
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RemchoVincent.Chemistry.ARTWORK.zip
This report details preliminary studies towards the development of a microfluidic
sensor that exploits ferromagnetic resonance, excited in magnetic bead labels, for signal
transduction. The device consists of a microwave circuit in which a slotline and a coplanar
waveguide are integrated with a biochemically activated sensor area. The magnetic beads are
immobilized in the sensor area by bio-specific reactions. A microwave signal applied to the
slotline is coupled to the coplanar waveguide only in the presence of magnetic beads at the
functionalized sensor area. Ferromagnetic resonance in the beads further enhances the coupling.
This inductive detection technique lends itself to miniaturization, is inexpensive to fabricate and
can be adapted for the detection of a wide range of molecules for which bio-specific ligands are
available.
Experimentally, the variation of the output signal as a function of the location of magnetic beads
was studied for the proposed technique. Subsequently, a prototype device was constructed by
biotinylation of the sensor area and integration with a microfluidic chip fabricated in
polydimethyl siloxane (PDMS). Preliminary experiments were conducted on this prototype using
streptavidin-functionalized magnetic beads as labels. It was shown that the magnetic beads,
immobilized at the sensor area by streptavidin-biotin linkage, produced a distinct ferromagnetic
resonance response easily discernible from the background signal